Hotels in Wapello

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Check prices for these dates

Tonight
Dec 29 - Dec 30
Tomorrow
Dec 30 - Dec 31
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Where to stay in Wapello?

Double Room, 2 Double Beds | Pillowtop beds, desk, blackout drapes, iron/ironing board
Super 8 by Wyndham Mt Pleasant
Super 8 by Wyndham Mt Pleasant
2.0 star property
8.2 out of 10, Very Good, (842)
The price is CNY453
CNY507 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Super 8 by Wyndham Mt Pleasant
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Budget hotels in Wapello and vicinity

Indoor pool
AmericInn by Wyndham West Burlington

AmericInn by Wyndham West Burlington

AmericInn by Wyndham West Burlington
2.5 star property
West Burlington
7.0 out of 10, Good, (833)
The price is CNY429
CNY480 total
includes taxes & fees
Jan 11 - Jan 12, 2026
AmericInn by Wyndham West Burlington
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Wapello

The region around Wapello is home to attractions such as Mississippi River and Cairo Woods Wildlife Area.

See all hotels in Wapello
The Mississippi River near Hannibal, Missouri, USA

Check out reviews of Wapello hotels guests love

Hampton Inn & Suites Burlington

Hampton Inn & Suites Burlington

10/10 Excellent
"It was a great stay. Check in was quick and easy and the room was very clean. No complaints."
Paul 1-night trip
Posted 2 days ago
Hampton Inn & Suites Burlington

Frequently asked questions

How much does a hotel room cost in Wapello?
You can choose a great hotel in Wapello from CNY427 with properties to suit all budgets and needs. If you're looking for an affordable hotel in Wapello that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.
How can I find deals and earn rewards at Wapello hotels?
Discover great deals on Wapello hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If it's a spontaneous trip, check out our last-minute deals on Wapello hotels.
Can I book Wapello hotels with free cancellation?
In order to book a refundable Wapello hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
Can I book a refundable accommodation in Wapello?
If you want the flexibility to change your plans to Wapello, most properties offer refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Wapello be like during my trip?
July and August are typically the warmest months in Wapello when the average temp is 72°F. January and February are the coldest months when the average temperature is 30°F. June and May are the months with the most rain.
Why should I book my Wapello accommodation with Hotels.com?
There are lots of reasons to book your Wapello trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.