Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Santa Clara on Hotels.com. These Santa Clara hotels consistently deliver on quality, location and traveler experience. Last updated on .
Hotels in Santa Clara
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Tonight
Sep 5 - Sep 6Tomorrow
Sep 6 - Sep 7Next weekend
Sep 11 - Sep 13In two weeks
Sep 18 - Sep 20Where to stay in Santa Clara?
Riande Aeropuerto Hotel & Casino
Riande Aeropuerto Hotel & CasinoTocumen
CNY726
CNY799 total
includes taxes & fees
Sep 6 - Sep 7
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama CityJuan Diaz
CNY1,758
CNY1,934 total
includes taxes & fees
Sep 6 - Sep 7
Summit Rainforest Golf Resort & All Inclusive
Summit Rainforest Golf Resort & All InclusivePanama City
CNY1,441
CNY1,585 total
includes taxes & fees
Sep 13 - Sep 14
Gamboa Rainforest Reserve
Gamboa Rainforest ReserveColon
CNY931
CNY1,024 total
includes taxes & fees
Sep 30 - Oct 1
Courtyard by Marriott Panama Metromall
Courtyard by Marriott Panama MetromallSan Antonio
CNY707
CNY778 total
includes taxes & fees
Sep 12 - Sep 13
MARINN Tropical Vibes Hotel
MARINN Tropical Vibes HotelAmador
CNY596
CNY656 total
includes taxes & fees
Sep 7 - Sep 8
Best Western El Dorado Panama Hotel
Best Western El Dorado Panama HotelBethania
CNY671
CNY738 total
includes taxes & fees
Sep 6 - Sep 7
Radisson Hotel Panama Canal
Radisson Hotel Panama CanalAmador
CNY688
CNY757 total
includes taxes & fees
Sep 18 - Sep 19
Marriott Panama Hotel
Marriott Panama HotelPanama City
CNY1,080
CNY1,188 total
includes taxes & fees
Sep 13 - Sep 14
Ramada Plaza by Wyndham Panama Punta Pacifica
Ramada Plaza by Wyndham Panama Punta PacificaSan Francisco
CNY696
CNY766 total
includes taxes & fees
Sep 7 - Sep 8
The Beach House
The Beach HouseAmador
CNY516
CNY568 total
includes taxes & fees
Sep 6 - Sep 7
The Westin Playa Bonita Panama
The Westin Playa Bonita PanamaVeracruz
CNY1,323
CNY1,455 total
includes taxes & fees
Sep 25 - Sep 26
Sofitel Legend Casco Viejo, Panama City
Sofitel Legend Casco Viejo, Panama CityCasco Viejo
CNY2,388
CNY2,627 total
includes taxes & fees
Sep 20 - Sep 21
JW Marriott Panama
JW Marriott PanamaSan Francisco
CNY1,820
CNY2,002 total
includes taxes & fees
Sep 26 - Sep 27
Dreams Playa Bonita Panama - All Inclusive
Dreams Playa Bonita Panama - All InclusiveVeracruz
CNY1,867
CNY1,867 total
includes taxes & fees
Oct 1 - Oct 2
Sheraton Grand Panama
Sheraton Grand PanamaSan Francisco
CNY1,178
CNY1,295 total
includes taxes & fees
Sep 11 - Sep 12
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn HotelSan Francisco
CNY693
CNY762 total
includes taxes & fees
Sep 27 - Sep 28
Hotel Riu Plaza Panama
Hotel Riu Plaza PanamaBella Vista
CNY825
CNY907 total
includes taxes & fees
Sep 28 - Sep 29
Albrook Inn
Albrook InnPanama City
CNY395
CNY435 total
includes taxes & fees
Sep 25 - Sep 26
Holiday Inn Panama Canal by IHG
Holiday Inn Panama Canal by IHGPanama City
CNY637
CNY775 total
includes taxes & fees
Oct 5 - Oct 6
Go beyond your typical stay in Santa Clara
Pet friendly
Apartment
Apart hotel
Family friendly
Top landmarks in Santa Clara
Culebra Cut
8.0/10 (14 reviews)
If you're planning a bit of sightseeing during your trip, head to Culebra Cut— just one of the landmarks located 5.8 mi (9.3 km) from central Santa Clara.
Learn more about Santa Clara
The region around Santa Clara is home to attractions such as Culebra Cut and Albrook Shopping Mall.
See all hotels in Santa Clara
Check out reviews of Santa Clara hotels guests love
Hotel Riu Plaza Panama
8/10 Good
"The property is lovely and has all the amenities. The Staff is great! Food was good. I was disappointed with my bathroom. Sticky stuff on the floor. The toilet did not flush properly had to call maintenance. The pool didn’t have a deep end. It being so hot, I wanted to swim more."
Dreams Playa Bonita Panama - All Inclusive
10/10 Excellent
"Good food and friendly staff"
Decapolis Hotel Panama City
8/10 Good
"My son and I stayed one night at the Decapolis Hotel, and while the property itself is impressive, the overall experience was mixed. The hotel is immaculately clean, centrally located, and offers great views of the city. We enjoyed the modern amenities, including the large pool, glass elevator, and the convenient skywalk that connects directly to a shopping center. Unfortunately, the service did not match the quality of the facilities. Staff members were curt and unhelpful, and when we asked questions, we were often shrugged off or redirected without explanation. Other guests were assisted while we were ignored, which left a negative impression. The hotel’s open‑lobby design also created a major issue: an event took place late into the night, and the noise carried all the way up to the rooms. We weren’t able to sleep until it ended past midnight. Check‑in was another challenge. Tour groups arrived at the same time, and although two staff members were present, only one was willing to check us in. The other employee was checking in random guests but refused to assist us, pointing us toward the long tour‑group line instead. Checkout, however, was quick and easy. Overall, the hotel has excellent facilities and a great location, but the service and noise issues significantly impacted our stay."
Megapolis Hotel Panamá
8/10 Good
"I thoroughly enjoyed my stay with a fantastic view from both bedrooms. The staff were extremely pleasant and helpful. My Spanish is very limited and almost everyone was able to communicate with me using English. I looked forward to breakfast every morning as they had a wide variety of dishes to choose from. I most definitely will be back!"
Principe Hotel and Suites
10/10 Excellent
"Nice"
The Executive Hotel
10/10 Excellent
"My five stars said it all. Maybe microwave could be added to the room. Breakfast was lovely"
Ramada Plaza by Wyndham Panama Punta Pacifica
10/10 Excellent
"9.5 out 10. Our Check-In was a bit to slow. Otherwise everything else was fine. Breakfast here is always a highlight. Breakfast here."
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
8/10 Good
"This is our 2nd stay at your hotel and our stay was great as usual. Breakfast was consistent and satisfying. Staff was very helpful and pleasant. Keep it up."
Aloft by Marriott Panama
10/10 Excellent
"Excelente"