Hotels in Mill Creek

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Sep 25 - Sep 26

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Sep 26 - Sep 27

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Sep 25 - Sep 27

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Where to stay in Mill Creek?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Mill Creek on Hotels.com. These Mill Creek hotels consistently deliver on quality, location and traveler experience. Last updated on September 25, 2026.

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

1. The Riverview

Cape Girardeau

CNY767

CNY865 total

includes taxes & fees

Sep 28 - Sep 29

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

CNY678

CNY771 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

A spacious living room with a sofa set, a coffee table, and a dining area.

A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.

A lobby with seating areas, a reception desk, and a bar.

3. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

CNY870

CNY986 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

4. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

CNY671

CNY757 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

5. Pear Tree Inn Cape Girardeau West

Cape Girardeau

CNY483

CNY545 total

includes taxes & fees

Oct 4 - Oct 5

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

An outdoor patio with stone walls, wicker furniture, and large windows.

A gym with exercise equipment, a treadmill, and a wall-mounted TV.

A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

6. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

CNY710

CNY801 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

7. Drury Inn & Suites Cape Girardeau

Cape Girardeau

CNY617

CNY696 total

includes taxes & fees

Oct 4 - Oct 5

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

8. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

CNY679

CNY766 total

includes taxes & fees

Oct 1 - Oct 2

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.

A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

9. Quality Inn Cape Girardeau North

Cape Girardeau

CNY402

CNY454 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.

A bathroom with a marble wall and a white bathtub.

A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.

10. Town House Inn Cape Giradreau

Cape Girardeau

CNY503

CNY588 total

includes taxes & fees

Sep 27 - Sep 28

A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.

A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.

A rustic building with a thatched roof, surrounded by dense greenery and a gravel path leading to it.

A cozy log cabin interior with a wooden staircase, a cushioned sofa, a small table, and a lamp.

11. Makanda Inn

Makanda

CNY1,758

CNY2,004 total

includes taxes & fees

Oct 1 - Oct 2

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.

An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

A hotel room with a bed, a TV, a desk, and a chair.

12. Candlewood Suites Cape Girardeau by IHG

Cape Girardeau

CNY571

CNY681 total

includes taxes & fees

Oct 11 - Oct 12

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Go beyond your typical stay in Mill Creek

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Check out reviews of Mill Creek hotels guests love

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

A spacious living room with a sofa set, a coffee table, and a dining area.

A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.

A lobby with seating areas, a reception desk, and a bar.

Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

10/10 Exceptional

United States

Keri

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

The Riverview

Cape Girardeau

10/10 Exceptional

United States

Mark

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

10/10 Exceptional

United States

Janet

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

Pear Tree Inn Cape Girardeau West

Cape Girardeau

10/10 Exceptional

United States

Kimberly

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

Drury Inn & Suites Cape Girardeau

Cape Girardeau

10/10 Exceptional

United States

StephM

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