Hotels in La Mesa

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Where to stay in La Mesa?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in La Mesa on Hotels.com. These La Mesa hotels consistently deliver on quality, location and traveler experience. Last updated on October 7, 2026.

A modern kitchen with a large TV, bar stools, and a scenic view.

A breakfast buffet with various food options, a coffee station, and a view of the surrounding landscape.

A modern living room with a leather sofa, a bookshelf, and a staircase leading to an outdoor area.

A modern outdoor dining area with tables and chairs, large windows offering a view of hills, and various outdoor kitchen appliances.

1. Tryp By Wyndham Ciudad Guzman Uttsa

Zapotlán el Grande

CNY557

CNY674 total

includes taxes & fees

Nov 1 - Nov 2

A courtyard with a swimming pool, surrounded by plants and stone walls.

A multi-level outdoor area with seating, potted plants, and decorative elements.

A multi-level atrium with a glass ceiling, balconies with hanging planters, and a central planter with various plants.

A spacious lobby with a central seating area, multiple balconies with hanging plants, and a tiled floor.

2. Hotel Zapotlan

Zapotlán el Grande

CNY236

CNY286 total

includes taxes & fees

Oct 8 - Oct 9

A restaurant interior with a projection screen displaying a nature scene, wooden furniture, and a modern chandelier.

A bedroom with a large bed, a nightstand, a chair, and a balcony with a view of the city.

3. Hotel Uttsa Inn Tamazula

Tamazula de Gordiano

CNY280

CNY339 total

includes taxes & fees

Oct 8 - Oct 9

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and greenery.

A breakfast table set with plates, cups, and a fruit bowl, with a view of a corridor leading to a dining area.

A spa area with a pool, towels, and decorative wall elements.

A corridor with tiled flooring, potted plants, and a wooden ceiling.

4. La Casa de los Patios Hotel & Spa

Sayula

CNY462

CNY559 total

includes taxes & fees

Oct 12 - Oct 13

A swimming pool surrounded by yellow buildings with balconies, a clear sky, and a staircase leading to an upper level.

A reception area with a white reception desk, a framed picture above the desk, and potted plants on either side.

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A lobby with wicker furniture, a glass-top coffee table, and a large mirror.

5. Capital O Colón, Ciudad Guzmán Jalisco

Zapotlán el Grande

CNY148

CNY189 total

includes taxes & fees

Oct 25 - Oct 26

A courtyard with a swimming pool, multiple balconies, and a dining area with tables and chairs.

A room with a high ceiling, wooden beams, a chandelier, and a large window.

A reception area with a wooden reception desk, a black leather chair with a pillow, a television mounted on the wall, and a decorative wall with hanging elements.

An elegantly set dining table with glassware, floral centerpieces, and a framed painting on the wall.

6. Gran Casa Sayula Hotel & Spa

Sayula

CNY665

CNY804 total

includes taxes & fees

Oct 8 - Oct 9

A patio with outdoor furniture, a wall-mounted decorative mirror, and a variety of plants.

A building with a sign reading 'CASA REAL' and a large tree in front.

A bed with a white bedspread, a dark brown skirt, and a heart-shaped decoration made of rose petals.

7. Hotel Boutique Casa Real

Zapotiltic

CNY326

CNY395 total

includes taxes & fees

Oct 8 - Oct 9

View all properties

Check out reviews of La Mesa hotels guests love

Tryp By Wyndham Ciudad Guzman Uttsa

10/10 Excellent

"El mejor hotel de ciudad guzmán"

Hotel Uttsa Inn Tamazula

10/10 Excellent

"Business friendly, good customer service!"

Hotel Zapotlan

10/10 Excellent

"Clean room"

Capital O Colón, Ciudad Guzmán Jalisco

10/10 Excellent

"There were no towels in the room. I had to go to reception to get the towels, but there was only one towel, I had to wait until next day to get the second towel. Other than that It was a great place. I would go back and stay"

Gran Casa Sayula Hotel & Spa

10/10 Excellent

"This is the place to be. The rooms are clean. The staff is wonderful. Although it was in the plan to get a spa treatment, I didn't get one done because I didn't have enough time. But overall, the place was spectacular and I would stay there again and I highly recommend it."

Lofts Independencia Sayula

8/10 Good

" Room very clean staff very friendly Good location I'm satisfied I'll recommend "

Tryp By Wyndham Ciudad Guzman Uttsa

8/10 Good

"Stayed for two nights during the Fiestas. Super close to the Féria. However a bit far from the center. Staff was very helpful and room comfortable and clean. Good place to stay if you don’t mind taking a cab into town or driving in and you want some quiet."

Frequently asked questions

How much does a hotel room cost in La Mesa?

You can find top hotels in La Mesa from CNY189 with options to suit your budget and needs. If you're after an affordable hotel in La Mesa that meets all of your requirements, set your filters and then sort the results by "Price: low to high".

How can I find deals and earn rewards at La Mesa hotels?

Discover great deals on La Mesa hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If it's a spontaneous trip, check out our last-minute deals on La Mesa hotels.

Can I book La Mesa hotels with free cancellation?

To book a refundable La Mesa hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some top pet-friendly hotels in La Mesa?

Consider one of our travelers' favorite pet-friendly hotels in La Mesa:

Chalet de Colombo Hotel: A ranch with a guest rating of 9 out of 10

You can also use the "Amenities" filter in your search on Hotels.com and check "Pet friendly" to discover more pet-friendly hotels in La Mesa.

What are some of the best La Mesa hotels with free parking?

If you're arriving by car, choosing a great La Mesa hotel with free parking is a plus. Our travelers' favorites include:

Chalet de Colombo Hotel: A ranch with an average guest rating of 9 out of 10

What are some popular hotels in central La Mesa?

If you're looking for hotels in central La Mesa, check out Tryp By Wyndham Ciudad Guzman Uttsa and Chalet de Colombo Hotel. Travelers love Tryp By Wyndham Ciudad Guzman Uttsa for its location, as well as the restaurant, free on-the-go breakfast and Netflix this hotel offers. Chalet de Colombo Hotel is another popular central ranch with a terrace and free parking, plus free WiFi in the guestrooms.

What hotels do travelers like in La Mesa?

Guests like Chalet de Colombo Hotel, Tryp By Wyndham Ciudad Guzman Uttsa and Hotel Zapotlan.

Can I book refundable hotels in La Mesa?

If you need the flexibility to change your travel plans to La Mesa, most properties offer refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in La Mesa be like during my vacation?

The warmest months in La Mesa are usually May and April with an average temp of 70°F. January and February are the chilliest months when the average temp is 63°F. The rainiest months are August and July.

Why should I book my La Mesa hotel through Hotels.com?

There are plenty of reasons to book your La Mesa travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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