Hotels in Santa Isabel

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Where to stay in Santa Isabel?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Santa Isabel on Hotels.com. These Santa Isabel hotels consistently deliver on comfort, location and traveler experience. Last updated on August 19, 2026.

Holiday Inn Mexicali Centro Civico by IHG

Civic Center

Comfort Room, Non Smoking, City View | Television

Hotel del Norte

Mexicali Historic Center

CNY354

CNY457 total

includes taxes & fees

Aug 20 - Aug 21

Hotel Lucerna Mexicali

Mexicali

CNY739

CNY835 total

includes taxes & fees

Aug 23 - Aug 24

Hotel Colonial Mexicali

Civic Center

CNY635

CNY717 total

includes taxes & fees

Aug 20 - Aug 21

City Express Plus by Marriott Mexicali

Mexicali

CNY636

CNY719 total

includes taxes & fees

Aug 23 - Aug 24

Holiday Inn Express & Suites Mexicali by IHG

Mexicali

CNY907

CNY1,025 total

includes taxes & fees

Aug 21 - Aug 22

Deluxe Room | Living area | 55-inch Smart TV with cable channels

Deluxe Room | Blackout drapes, soundproofing, WiFi (free), bed sheets

Motel Virreyes

Mexicali

CNY288

CNY331 total

includes taxes & fees

Aug 20 - Aug 21

Superior Room | Premium bedding, pillowtop beds, minibar, in-room safe

Hotel Araiza Mexicali

Mexicali

CNY763

CNY862 total

includes taxes & fees

Aug 20 - Aug 21

Superior Room, 2 Twin Beds | Premium bedding, in-room safe, desk, WiFi (free)

One Mexicali

Mexicali

CNY445

CNY503 total

includes taxes & fees

Aug 28 - Aug 29

Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas

Fairfield Inn & Suites by Marriott Mexicali

Mexicali

CNY742

CNY838 total

includes taxes & fees

Aug 23 - Aug 24

City Express by Marriott Mexicali

Mexicali

CNY594

CNY671 total

includes taxes & fees

Aug 23 - Aug 24

Standard Room, 2 Double Beds | Desk, iron/ironing board (on request), WiFi (free)

Hotel Cosmos Don Carlos

Mexicali

CNY316

CNY357 total

includes taxes & fees

Aug 20 - Aug 21

City Express Junior by Marriott Mexicali

Mexicali

CNY436

CNY493 total

includes taxes & fees

Aug 23 - Aug 24

Double Room, 1 Double Bed | Iron/ironing board (on request), rollaway beds (free), WiFi (free)

Double Room, 1 Double Bed | Bathroom | Shower, towels

Motel Las Fuentes

Mexicali

CNY272

CNY334 total

includes taxes & fees

Aug 20 - Aug 21

Sleep Inn Mexicali

Mexicali

CNY487

CNY589 total

includes taxes & fees

Aug 28 - Aug 29

In-room safe, desk, blackout drapes, iron/ironing board

Fiesta Inn Mexicali

Civic Center

CNY566

CNY640 total

includes taxes & fees

Sep 4 - Sep 5

Calafia Hotel

Mexicali

CNY504

CNY570 total

includes taxes & fees

Aug 25 - Aug 26

Azteca de Oro Mexicali

Mexicali

CNY316

CNY357 total

includes taxes & fees

Aug 20 - Aug 21

Cooked-to-order breakfast for a fee on weekdays

Hotel Siesta Real

Mexicali

CNY540

CNY610 total

includes taxes & fees

Aug 20 - Aug 21

Double Room | Soundproofing, WiFi (free), bed sheets

Double Room | Bathroom | Free toiletries, towels, soap, shampoo

Motel Diana

Mexicali

CNY243

CNY279 total

includes taxes & fees

Aug 20 - Aug 21

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Go beyond your typical stay in Santa Isabel

Pool

Family friendly

Check out reviews of Santa Isabel hotels guests love

Hotel Araiza Mexicali

10/10 Excellent

"Absolutely love this hotel, The staff, the rooms, the cleanliness and just overall 10/10! Every time I go to Mexicali it is the only Hotel we stay at!! The location convenience is also amazing!!! Not to mention it has a Starbucks in the parking lot!!!"

Hotel Lucerna Mexicali

10/10 Excellent

"No breakfas included with my expedia reservation. Only one restaurant open and the food had no flavor. Good service"

Sleep Inn Mexicali

10/10 Excellent

"Room was small but clean, staff was very helpful."

Fiesta Inn Mexicali

10/10 Excellent

"La ubicación del hotel excelente muy accesible para lo que necesitara"

One Mexicali

10/10 Excellent

"The value is there , clean but basic. 2 pillows that suck, towels that scratch your skin , but for $65 is good place"

Fairfield Inn & Suites by Marriott Mexicali

10/10 Excellent

"Amazing stay"

Hotel Siesta Real

8/10 Good

"Everything is good"

Hotel Villa Del Sol

10/10 Excellent

"Hg"

Extended Suites Mexicali Cataviña

10/10 Excellent

"Good service, staff nice, parking available, clean room"

Frequently asked questions

How much does a hotel room cost in Santa Isabel?

You can choose a great hotel in Santa Isabel from CNY322 with properties to suit all budgets and needs. If you're after an affordable hotel in Santa Isabel that meets all of your requirements, set your filters and then sort the results by "Price: low to high".

How can I find deals and earn rewards at Santa Isabel hotels?

Discover great deals on Santa Isabel hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If it's a spontaneous trip, check out our last-minute deals on Santa Isabel hotels.

Can I book Santa Isabel hotels with free cancellation?

To book a refundable Santa Isabel hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some popular hotels in central Santa Isabel?

If you're looking for hotels in central Santa Isabel, check out Real Inn Mexicali and Hampton Inn by Hilton Calexico. Travelers love Real Inn Mexicali for its location, as well as the outdoor pool, restaurant and bar/lounge this hotel offers. Hampton Inn by Hilton Calexico is another popular central hotel with an outdoor pool, a hot tub and a free continental breakfast. Civic Center and Mexicali Historic Center are some of the most central neighborhoods for your Santa Isabel vacation.

What hotels do travelers recommend in Santa Isabel?

Guests like Hotel Araiza Mexicali, Hotel Lucerna Mexicali and Calafia Hotel.

Can I book a refundable hotel in Santa Isabel?

If you need the flexibility to change your plans to Santa Isabel, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Isabel be like during my trip?

July and August are typically the warmest months in Santa Isabel when the average temp is 93°F. December and January are the coldest months when the average temperature is 61°F. August and January are the months with the most rain.

Why should I book my Santa Isabel hotel through Hotels.com?

There are lots of reasons to book your Santa Isabel trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Keep exploring

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Book Hotels in Santa Isabel on www.hoteles.com