Mature patient, doctor and tablet for healthcare, support or conversation with checkup appointment in office. Female person, medical professional and diagnosis talk for senior woman at clinic

Hotels near OSF St. Mary Medical Center Galesburg

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Where to stay near OSF St. Mary Medical Center?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night near OSF St. Mary Medical Center on Hotels.com. These hotels close to OSF St. Mary Medical Center consistently deliver on quality, location and traveler experience. Last updated on September 12, 2026.

A hotel room with a large bed, a bathroom with a bathtub, and a mirror.

A breakfast bar with seating, a coffee machine, and a microwave.

A reception desk with a stone wall backdrop, a sign reading "AmerInn by Wyndham", and various amenities like a clock, a small plant, and a framed picture.

A compact living room with a sofa, two armchairs, a coffee table, a ceiling fan, and a framed picture on the wall.

1. AmericInn by Wyndham Galesburg

2.9 km from OSF St. Mary Medical Center

Candy

CNY564

CNY658 total

includes taxes & fees

Sep 29 - Sep 30

A hotel entrance with a covered patio, American flags, and a sunset sky.

A hotel room with a carpeted hallway, two front-loading washing machines, and a patterned wall.

An outdoor patio area with a covered seating area, a table, and chairs.

A modern office space with a glass desk, a black office chair, a computer, a refrigerator, and a window with blinds.

2. Quality Inn Galesburg near US Highway 34 and I-74

2.6 km from OSF St. Mary Medical Center

Kim

CNY563

CNY657 total

includes taxes & fees

Oct 4 - Oct 5

An indoor swimming pool with a wooden ceiling and lounge chairs.

A spacious lobby with wooden ceiling beams, comfortable seating, a kitchen area, and large windows offering a view of the outdoors.

A restaurant with a bar area, wooden ceiling beams, and a tiled floor.

A room with two desks, chairs, a jukebox, and two wall-mounted televisions.

3. Best Western Prairie Inn & Conference Center

5.5 km from OSF St. Mary Medical Center

Russell

CNY618

CNY721 total

includes taxes & fees

Oct 11 - Oct 12

A hotel entrance with a covered walkway, stone pillars, and a well-lit entrance.

A hotel reception area with a reception desk, seating area, and a view of the lobby.

A spacious indoor area with a long counter and several chairs, a television mounted on the wall, and large windows providing natural light.

A modern hotel lobby with a seating area, a reception desk, and a large window offering a view.

4. Holiday Inn Express & Suites Galesburg by IHG

4.9 km from OSF St. Mary Medical Center

Wes

CNY1,449

CNY1,692 total

includes taxes & fees

Oct 13 - Oct 14

A multi-story hotel with a covered entrance and a parking lot.

A reception area with a Baymont Inn & Suites sign, a reception desk, a seating area with chairs, and a hallway leading to other rooms.

An indoor swimming pool with a wooden ceiling, arched windows, and a lifeguard sign.

A hotel room with a bed, a sofa, a nightstand, a lamp, and a framed picture on the wall.

5. Galesburg Inn and Suites

4.9 km from OSF St. Mary Medical Center

Kristin

CNY593

CNY693 total

includes taxes & fees

Oct 4 - Oct 5

A staircase with metal railings, a large mirror reflecting a ceiling light fixture, and brick walls.

A hotel room with a bed, desk, chair, TV, and artwork.

A brick building with a sign reading 'Galesburg Extended Stay.'

A long, narrow hallway with white walls and a tiled floor, leading to multiple doorways at the end.

6. Galesburg Extended Stay I-74 (Newly Renovated)

5.5 km from OSF St. Mary Medical Center

Lane

CNY463

CNY541 total

includes taxes & fees

Sep 23 - Sep 24

A reception desk with a digital display, a fire extinguisher, and a refrigerator.

A compact kitchen with a microwave, coffee machine, and condiment dispensers.

A hotel room with a bed, a nightstand, a lamp, a wall-mounted air conditioner, and a window with curtains.

A hotel lobby with a reception desk, a bar area, and a seating section with tables and chairs.

7. Super 8 by Wyndham Galesburg

9.1 km from OSF St. Mary Medical Center

Veronica

CNY459

CNY510 total

includes taxes & fees

Oct 4 - Oct 5

A living room with a brown leather sofa, a brown leather chair, a TV on a stand, and a painting on the wall.

A compact kitchen with wooden cabinets, a stainless steel sink, and a built-in stove.

A two-story house with a front porch, a garage, and a well-maintained lawn.

A residential street with a sidewalk, a large tree, and houses with white siding.

8. < 1 Mi to Main St: Quiet Apartment in Galesburg!

3.3 km from OSF St. Mary Medical Center

CNY966

CNY1,607 total

includes taxes & fees

Sep 23 - Sep 24

View all properties

Compare popular hotels close to OSF St. Mary Medical Center

Property	Property class	Guest rating
AmericInn by Wyndham Galesburg	8.0 Very Good 1,001 reviews	View
Quality Inn Galesburg near US Highway 34 and I-74	7.2 Good 447 reviews	View
Best Western Prairie Inn & Conference Center	8.0 Very Good 361 reviews	View
Holiday Inn Express & Suites Galesburg by IHG	9.4 Exceptional 488 reviews	View
Galesburg Inn and Suites	7.8 Good 1,001 reviews	View

Frequently Asked Questions

What are the best hotels near OSF St. Mary Medical Center?

Guests love staying at Best Western Prairie Inn & Conference Center, which is a hotel near OSF St. Mary Medical Center.
You'll find 63 hotels, vacation rentals, and more to choose from within the area.

How much does it cost to stay in a hotel near OSF St. Mary Medical Center?

You can find a variety of room prices on Hotels.com depending on where you plan to go and when. To see the lowest rates available, filter by your preferred criteria and sort by price.

Search for the lowest price per night from CNY459

What are the best romantic hotels near OSF St. Mary Medical Center?

For a romantic stay, Best Western Prairie Inn & Conference Center offers an indoor pool. It's a short 6-minute drive from OSF St. Mary Medical Center.

What are the best hotels close to OSF St. Mary Medical Center with free breakfast?

Enjoy a free buffet breakfast to begin your day at Best Western Prairie Inn & Conference Center, which is a short 6-minute drive from OSF St. Mary Medical Center.

Which hotels near OSF St. Mary Medical Center have rooms with great views?

Enjoy rooms with golf course or courtyard views at Best Western Prairie Inn & Conference Center, which is a short 6-minute drive from OSF St. Mary Medical Center.

What are the best hotels near OSF St. Mary Medical Center with free parking?

Drive and park with ease when you stay at Quality Inn Galesburg near US Highway 34 and I-74, which offers free parking. You'll be a short 3-minute drive from OSF St. Mary Medical Center.
AmericInn by Wyndham Galesburg also has free parking and is a short drive away.

What are the best hotels near OSF St. Mary Medical Center with a pool?

If swimming is at the top of your list, Best Western Prairie Inn & Conference Center has an indoor pool. OSF St. Mary Medical Center is a short 6-minute drive from the hotel.

What cheap motels can I book close to OSF St. Mary Medical Center?

To save on your stay near OSF St. Mary Medical Center, take a look at Super 8 by Wyndham Galesburg, which offers an indoor pool and a free continental breakfast.

What are the best things to see and do around my hotel near OSF St. Mary Medical Center?

Sights like Knox College and Lake Storey are in the area near OSF St. Mary Medical Center.

What are the best pet-friendly hotels close to OSF St. Mary Medical Center?

Your pet companion can join you at Quality Inn Galesburg near US Highway 34 and I-74, which is a short 3-minute drive from OSF St. Mary Medical Center.
A second pet-friendly hotel is Holiday Inn Express & Suites Galesburg by IHG.

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