Hotels in Saltillo

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Where to stay in Saltillo?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Saltillo on Hotels.com. These Saltillo hotels consistently deliver on quality, location and traveler experience. Last updated on September 25, 2026.

A Holiday Inn Express hotel with a central entrance, multiple floors, and a parking lot.

A buffet with labeled containers of omelets and other dishes.

A spacious lobby with a high ceiling, modern lighting fixtures, and a central seating area with a patterned rug.

A large indoor swimming pool with a diving board and a changing room area.

1. Holiday Inn Express Hotel & Suites Fulton by IHG

Fulton

CNY638

CNY702 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a large bed, a small desk, a mirror, a TV, and a microwave.

A hotel room with a kitchenette, a dining area with wooden chairs and a table, and a large window offering a view.

A hotel room with a glass table, two leather armchairs, a TV, and a large window offering a view of the parking lot.

A multi-story hotel with balconies, blue doors, and a parking lot.

2. Days Inn by Wyndham Fulton

Fulton

CNY497

CNY546 total

includes taxes & fees

Oct 4 - Oct 5

A hotel lobby with a reception desk, seating area with ottomans, and a patterned carpet.

A hotel room with a bed, a sofa, two ottomans, a nightstand with a lamp, and two framed pictures on the wall.

A kitchen with granite countertops, wooden cabinets, and a tiled backsplash.

An indoor swimming pool with a clear view of the pool area, including the poolside seating and the pool's edge.

3. Best Western Plus Tupelo Inn & Suites

Tupelo

CNY695

CNY759 total

includes taxes & fees

Sep 27 - Sep 28

A modern, well-lit office space with multiple tables and chairs, a reception area, and large windows offering a view of greenery.

A modern building with large windows and a patio area with white metal furniture.

A hotel room with a bed, a sofa, a desk, and a lamp.

A modern lobby with a reception desk, yellow chairs, a round table, and a large window.

4. Spark by Hilton Tupelo

Tupelo

CNY661

CNY722 total

includes taxes & fees

Oct 4 - Oct 5

A large indoor swimming pool with multiple seating areas and large windows.

A reception desk with a "Welcome to Hampton" sign, a "Hilton Honors" plaque, and a view of a building through a window.

A hotel with a modern design, featuring a covered entrance and a parking lot.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

5. Hampton Inn & Suites Tupelo/Barnes Crossing

Tupelo

CNY920

CNY1,005 total

includes taxes & fees

Oct 4 - Oct 5

A reception area with a stone wall, a painting of autumn trees, and a potted plant.

A living room with a sofa, chairs, a coffee table, a flat-screen TV, a ceiling fan, and artwork on the walls.

A hotel with a red roof and a sign indicating it is an Americor Best Value Inn.

A hotel room with a bed, two bedside tables with lamps, a sofa, and a small table.

6. Americas Best Value Inn Tupelo Barnes Crossing

Tupelo

CNY470

CNY543 total

includes taxes & fees

Oct 7 - Oct 8

A Fairfield Inn & Suites Marriott hotel with a modern facade, a covered entrance, and a parking area.

A hotel lobby with a central bar area, seating arrangements, and a buffet with pastries.

An outdoor patio with round tables and chairs, potted plants, and a building with a modern design.

7. Fairfield Inn & Suites by Marriott Tupelo

Tupelo

CNY689

CNY752 total

includes taxes & fees

Oct 25 - Oct 26

A modern lounge area with a neon sign, large windows, and a pool table.

A modern interior with a brick wall, large windows, and a wooden floor.

A modern hotel with a brick facade, large windows, and a covered outdoor seating area.

A modern living room with a blue sofa, a round coffee table, and a cityscape view through large windows.

8. Hotel Tupelo, a Wyndham Hotel

Tupelo

CNY1,069

CNY1,168 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bed, a desk with a chair, a television, and a wall-mounted TV.

A room with a brown leather sofa, a matching armchair, a wooden coffee table with magazines, and a view of a gas station through large windows.

A framed black and white cityscape with 'Greetings from Booneville' and 'Mississippi' text, a steamboat, and a dome building.

A breakfast area with wooden flooring, a large window, and a view of parked trucks outside.

9. Super 8 by Wyndham Booneville

Booneville

CNY577

CNY629 total

includes taxes & fees

Sep 27 - Sep 28

A modern hotel lobby with a reception desk, seating area, and unique lighting fixtures.

A breakfast buffet area with various food items and a coffee machine.

A modern lounge area with a blue sofa, grey armchairs, and a hanging chair.

A snack display in a store with various brands and types of snacks.

10. Tru By Hilton Tupelo

Tupelo

CNY655

CNY716 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with two beds, a desk, a chair, a television, and a window.

A hotel fitness center with multiple treadmills, ellipticals, and a mirrored wall.

A hotel lobby with a chandelier, leather chairs, a fireplace, and a television.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a counter.

11. Holiday Inn Express Hotel & Suites Tupelo by IHG

Tupelo

CNY691

CNY755 total

includes taxes & fees

Oct 25 - Oct 26

A multi-story hotel with a prominent entrance, a covered patio area, and a landscaped courtyard.

A hotel room with a large bed, a desk, a chair, a TV, and a window with patterned curtains.

A lobby with patterned sofas, a coffee machine, a television, and a snack vending machine.

A spacious lobby with patterned seating, a stone accent wall, a flat-screen TV, and a snack bar.

12. La Quinta Inn & Suites by Wyndham Tupelo

Tupelo

CNY658

CNY719 total

includes taxes & fees

Sep 28 - Sep 29

An outdoor seating area with chairs and a fire pit, a brick building, and a clear sky.

An indoor swimming pool with clear blue water, surrounded by yellow and blue chairs, and a water fountain on the left.

A gym with exercise equipment, a spinning bike, and a bench.

A modern lounge area with a green sofa, red chairs, and a wooden table.

13. Home2 Suites By Hilton Tupelo, Ms

Tupelo

CNY772

CNY843 total

includes taxes & fees

Oct 11 - Oct 12

A spacious hotel lobby with a dining area, sofas, and a TV mounted on the wall.

A reception area with a stone wall, wooden reception desk, and a vending machine.

A hotel room with a wooden desk, a blue sofa, a small ottoman, a chair, a lamp, and framed pictures on the wall.

A hotel room with a bed, a desk, a chair, a sofa, a TV, and a lamp.

14. Comfort Suites North Tupelo

Tupelo

CNY591

CNY645 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a central reception desk, large potted plants, and a modern chandelier.

A hotel lobby with a seating area, large windows, and a fireplace.

A modern lounge area with wicker furniture, a large wooden pendant light, and a colorful striped carpet.

A spacious living room with a fireplace, comfortable seating, and a coffee table with fruit.

15. Hilton Garden Inn Tupelo

Tupelo

CNY710

CNY776 total

includes taxes & fees

Oct 2 - Oct 3

A Holiday Inn & Suites hotel with a modern design, featuring a covered entrance and a parking lot.

A hotel dining area with multiple tables set for guests, featuring a carpeted floor and modern decor.

An outdoor seating area with wicker furniture and planters, a paved walkway, and a building with large windows.

16. Holiday Inn Hotel & Suites Tupelo North by IHG

Tupelo

CNY792

CNY865 total

includes taxes & fees

Oct 4 - Oct 5

A Courtyard Marriott hotel entrance at night with a well-lit facade, a covered parking area, and a landscaped garden.

An outdoor patio area with a fire pit, seating, and a view of the interior through large windows.

A modern lobby with a reception desk, seating area, and a large abstract mural.

A hotel room with a bed, a sofa, a desk, and a TV.

17. Courtyard By Marriott Tupelo

Tupelo

CNY779

CNY852 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, a wooden ceiling, a TV, a desk, and a bathroom visible in the background.

A reception area with a blue curtain backdrop, a reception desk, and a sign that reads "Baymont Inn & Suites."

A hotel room with a wooden floor, a desk with a chair, a sofa, a TV, a mini-fridge, and a sliding door leading to a balcony.

A wooden deck with chairs overlooking a pool area.

18. Baymont by Wyndham Tupelo

Tupelo

CNY479

CNY524 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a blue and white color scheme, featuring a leather sofa, a wooden coffee table, and a reception desk.

A gym with cardio machines, a weight bench, and a mirrored wall.

A dining area with wooden tables and chairs, a kitchen area with appliances, and a door leading to another room.

A spacious living area with a leather sofa, a glass coffee table, and a vending machine.

19. Econo Lodge Tupelo Barnes Crossing

Tupelo

CNY384

CNY420 total

includes taxes & fees

Oct 26 - Oct 27

A hotel room with a bed, a desk with a flat-screen TV, a microwave, a sink, and a mirror.

A modern kitchen with dark cabinetry, a central island, and a built-in range hood.

A hotel lobby with a red chair, a table with stacked items, and a large window offering a view of the parking lot and trees.

A reception area with a counter, a red chair, a small table with a lamp, and a view of the parking lot outside.

20. Motel 6 Tupelo, MS - Downtown

Tupelo

CNY423

CNY462 total

includes taxes & fees

Sep 27 - Sep 28

View all properties

Go beyond your typical stay in Saltillo

Pet friendly

Pool

Family friendly

Top landmarks in Saltillo

Saltillo City Hall

Saltillo City Hall is worth a visit when in central Saltillo.

See properties

Check out reviews of Saltillo hotels guests love

Red Roof Inn Tupelo

10/10 Excellent

"The place was clean, clean bathroom! Very nice friendly."

American Inn - Pontotoc

8/10 Good

"It is a little dated"

Best Western Plus Tupelo Inn & Suites

10/10 Excellent

"Our stay was excellent, booked our room on the fly with no problems,room was very clean and comfy, staff was great even as late as we got there, breakfast was very good had a good buffet style. Getting to the motel is kind of a pain but Google maps gave very good directions to get to and leaving, this was our second stay here and it was very enjoyable. We did not ask for an upgrade on the room."

Baymont by Wyndham Tupelo

8/10 Good

"N/A"

La Quinta Inn & Suites by Wyndham Tupelo

8/10 Good

"The room was clean and well prepared. The staff were very friendly and answered questions from check in to check out. We stayed at 5 different hotels on this vacation and the staff here were the most welcoming of us and our dog. Though others "welcomed" pets they were not very welcoming, but LaQuinta was different. There were some problems with breakfast equipment, but they were working to fix it."

Frequently asked questions

How much does a hotel room cost in Saltillo?

You can choose a great hotel in Saltillo from CNY326 with properties to suit all budgets and needs. If you're after an affordable hotel in Saltillo that meets all of your requirements, set your filters and then sort the results by "Price: low to high".

How can I find deals and earn rewards at Saltillo hotels?

Discover great deals on Saltillo hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on Saltillo hotels.

Can I book Saltillo hotels with free cancellation?

In order to book a refundable Saltillo hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some popular hotels in central Saltillo?

If you're looking for hotels in central Saltillo, check out Hampton Inn & Suites Tupelo/Barnes Crossing. Travelers love Hampton Inn & Suites Tupelo/Barnes Crossing for its location, as well as the indoor pool, free buffet breakfast and gym this hotel offers.

What accommodations do travelers like in Saltillo?

Guests like Best Western Plus Tupelo Inn & Suites, Red Roof Inn Tupelo and Holiday Inn Hotel & Suites Tupelo North by IHG.

Can I book refundable accommodations in Saltillo?

If you want the flexibility to change your travel plans to Saltillo, most accommodations offer refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

Where can I stay in Saltillo if I want a vacation rental instead of a hotel?

You'll find 5 vacation homes on our site.

What will the weather in Saltillo be like during my visit?

July and August are typically the warmest months in Saltillo when the average temp is 78°F. January and February are the coldest months when the average temperature is 46°F. April and March are the months with the most rain.

Why should I book my Saltillo hotel through Hotels.com?

There are plenty of reasons to book your Saltillo travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Keep exploring

Book Hotels in Saltillo on Hotels.com