A large steel bridge with a curved arch, surrounded by trees and a partly cloudy sky.

Business Hotels in O'Fallon

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Business Hotels in O'Fallon

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in O'Fallon on Hotels.com. These O'Fallon Business Hotels consistently deliver on quality, location and traveler experience. Last updated on September 22, 2026.

A hotel room with a bed, two bedside lamps, a chair, a desk with a telephone, and a large cityscape poster on the wall.

A swimming pool with a tiled deck, safety chairs, and a lifeguard sign.

A reception area with a counter, a utility room door, and a bulletin board with posted notices.

A diner-style restaurant with a counter, chairs, a coffee machine, and a wall poster.

1. Super 8 by Wyndham O'Fallon MO/St. Louis Area

O'Fallon

CNY478

CNY564 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a bed, a sofa, a coffee table, and wall art.

A hotel lobby with a reception desk, seating area, and a large potted plant.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

CNY552

CNY651 total

includes taxes & fees

Oct 12 - Oct 13

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

A modern hotel room with a desk, chair, and a large mirror.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

3. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

CNY636

CNY750 total

includes taxes & fees

Oct 20 - Oct 21

A hotel room with a large bed, a sofa, a desk, and two framed pictures on the wall.

A reception area with a granite counter, red chairs, and framed artwork on the wall.

A gym with cardio machines, weightlifting equipment, and mirrors.

An indoor swimming pool with clear water, surrounded by a tiled floor and walls, with a pool ladder and a few chairs and tables nearby.

4. Comfort Inn & Suites St. Louis - O'Fallon

O'Fallon

CNY548

CNY646 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

5. Residence Inn by Marriott O'Fallon

O'Fallon

CNY877

CNY1,034 total

includes taxes & fees

Oct 8 - Oct 9

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

A spacious indoor area with a high ceiling and large windows, featuring multiple seating areas with sofas and chairs, and a visible outdoor view through the windows.

A seating area with three grey armchairs and a central glass-top table, a wooden floor, and a view of parked cars through large windows.

A spacious indoor area with multiple wooden tables and chairs, large windows, and a high ceiling with exposed beams.

6. Pear Tree Inn St. Louis Airport

St. Ann

CNY602

CNY709 total

includes taxes & fees

Oct 5 - Oct 6

A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

A modern lobby with a reception desk, seating area, and a dining section.

A Holiday Inn Express hotel with a modern design, featuring a covered entrance and multiple windows.

A hotel room with two beds, a desk, a blue sofa, and a TV.

7. Holiday Inn Express & Suites St Peters by IHG

St. Peters

CNY790

CNY950 total

includes taxes & fees

Sep 27 - Sep 28

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

A modern hotel entrance with a glass canopy, large windows, and a brick facade.

A swimming pool with a tiled deck, a sunlit room with a view, and a seating area with chairs.

8. Hyatt Place St. Louis/Chesterfield

Chesterfield

CNY837

CNY971 total

includes taxes & fees

Sep 24 - Sep 25

A hotel room with a bed, bedside table, lamp, TV, and a desk with a chair.

A spacious dining area with multiple tables and chairs, a kitchen area with dark cabinets, and a flat-screen TV mounted on the wall.

A spacious lobby with a patterned tile floor, a staircase, and seating areas.

A kitchen with a built-in refrigerator, a coffee maker, and a microwave. There are cabinets and a countertop with various items on it.

9. Quality Inn Saint Louis Airport

Woodson Terrace

CNY413

CNY507 total

includes taxes & fees

Oct 2 - Oct 3

A multi-level hotel lobby with seating areas, a reception desk, and large windows offering views.

A hotel room with a bed, two armchairs, a sofa, a small table, and a nightstand.

A hotel reception area with a counter, seating, and a staircase.

A pool area with two hot tubs, seating, and a view of the outdoors.

10. Drury Inn & Suites St. Louis Airport

Edmundson

CNY770

CNY903 total

includes taxes & fees

Oct 4 - Oct 5

A hotel with a modern design, featuring a covered entrance and multiple windows.

A modern living room with grey sofas, a coffee table, and a TV mounted on the wall.

An indoor swimming pool with a tiled deck, a lifeguard chair, and a view of the outside.

A hotel lobby with a reception desk, seating area, and artwork on the walls.

11. Best Western St. Louis Airport North Hotel & Suites

Hazelwood

CNY539

CNY659 total

includes taxes & fees

Sep 28 - Sep 29

A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

A Wingate hotel with a covered entrance, outdoor seating, and a parking lot.

A hotel room with a desk, chair, TV, and a framed picture on the wall.

A lobby with two orange armchairs, a small table, a flat-screen TV, framed pictures, and a wall-mounted shelf with decorative items.

12. Wingate by Wyndham St. Louis Airport

St. Ann

CNY751

CNY885 total

includes taxes & fees

Sep 27 - Sep 28

A modern interior with hanging pendant lights, large windows, and a view of the outside.

A modern hotel lobby with a high ceiling, multiple hanging pendant lights, a reception desk with a Missouri US 66 sign, and large windows allowing natural light.

A modern hotel with a covered entrance, brick facade, and a parking area.

A hotel room with a flat-screen TV, a wooden cabinet, a light-colored sofa, a matching ottoman, and a small table.

13. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Fenton

CNY632

CNY729 total

includes taxes & fees

Oct 6 - Oct 7

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

A modern dining area with a long table, multiple chairs, and a unique chandelier.

A modern lobby with blue seating, a reception desk, and large windows.

A multi-story hotel with a stone facade, a covered entrance, and a parking lot.

14. Hyatt Select St. Louis Airport

Woodson Terrace

CNY737

CNY906 total

includes taxes & fees

Oct 16 - Oct 17

A hotel with a covered entrance, a tower with signage, and a landscaped area with planters.

A covered outdoor seating area with a pergola, surrounded by landscaped bushes and a paved walkway.

A hotel lobby with multiple seating areas, including round tables and sofas, and a reception desk with a green plant.

A hotel room with two beds, a desk, a TV, and a window with curtains.

15. La Quinta Inn & Suites by Wyndham St. Louis Westport

Westport

CNY552

CNY640 total

includes taxes & fees

Oct 20 - Oct 21

An outdoor patio area with wicker furniture, a stone fire pit, and a building in the background.

A modern lobby with a sofa, armchairs, a coffee table, and a bookshelf.

A modern bar area with wooden furniture, a counter with a menu, and a seating area with tables and chairs.

16. Courtyard by Marriott St. Louis St. Peters

St. Peters

CNY807

CNY970 total

includes taxes & fees

Oct 12 - Oct 13

A spacious lobby with a reception desk, seating area, and a fireplace.

A dining area with round tables and white chairs, a kitchen counter with appliances, and a framed picture on the wall.

A lobby with a fireplace, several potted plants, a television, and a sofa.

A hotel room with a large bed, two bedside lamps, a nightstand with a phone and alarm clock, and two framed floral pictures on the wall.

17. Americas Best Value Inn & Suites St. Louis, St. Charles Inn

St. Charles

CNY512

CNY594 total

includes taxes & fees

Sep 23 - Sep 24

A modern restaurant with a bar area, seating, and a large vase of branches.

A modern reception area with a counter, vending machines, and a dark-colored wall.

A modern hotel lobby with a seating area, a flat-screen TV, and a bar.

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

18. Courtyard St. Louis Airport/Earth City

Bridgeton

CNY677

CNY807 total

includes taxes & fees

Sep 27 - Sep 28

A modern kitchen with white cabinets, a long countertop, and overhead lighting.

A hotel room with two beds, a desk with a television, a microwave, and a small refrigerator.

19. Elimwood Hotel, a Ramada by Wyndham

Riverport

CNY557

CNY646 total

includes taxes & fees

Sep 29 - Sep 30

A spacious lobby with a central round table, two sofas, and a chandelier.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.

20. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

CNY870

CNY1,010 total

includes taxes & fees

Sep 27 - Sep 28

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Top landmarks in O'Fallon

9-11 Memorial

7.6/10 (44 reviews)

If you're planning a bit of sightseeing head to 9-11 Memorial— just one of the monuments located 30.5 mi (49.2 km) from the center of St. Louis.

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CarShield Field

7.0/10 (20 reviews)

You can catch an event at CarShield Field, located 1.2 mi (2 km) from central O'Fallon.

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Alligator Creek Aquatic Center

6.4/10 (16 reviews)

Why not give yourself a treat with a trip to Alligator Creek Aquatic Center, just one of the family attractions in central O'Fallon. If you'd also like to explore some of the parks in O'Fallon, head to August A. Busch Memorial Conservation Area.

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Golf Headquarters Family Golfplex

Golf Headquarters Family Golfplex is 4.7 mi (7.5 km) from central O'Fallon, why not stop by during your stay.

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About the destination

O'Fallon is a family-friendly city where you can spend time checking out the local cuisine. Why not take time to see places like CarShield Field and 9-11 Memorial? While you're in town, don't miss a chance to see sights like Mississippi River and Alligator Creek Aquatic Center.

Keep exploring

Washington Avenue Historic District Vacation Rentals
Standard Link for Washington Avenue Historic District Vacation Rentals