Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Panama City on Hotels.com. These Panama City Resorts & Hotels with Spas consistently deliver on quality, location and traveler experience. Last updated on October 10, 2026.
Surrounded by immaculately maintained gardens, this waterfront wellness sanctuary offers rejuvenating body wraps and aromatherapy in outdoor treatment areas. Spotless rooms, attentive staff, and a swim-up bar create a perfectly balanced escape.
Massage therapists deliver sublime treatments in-room or at the spa, creating a haven of tranquility. Spacious rooms feature premium bedding, large balconies, and bay views. After pampering, savor Latin American cuisine at 3 restaurants with ocean vistas.
Eforea Spa beckons with hot stone massages and body wraps in couples treatment rooms. Sauna sessions and steam room visits complement facials, while casino gaming and poolside relaxation await beyond the spa sanctuary.
Spa journeys await at this Belle Époque sanctuary in Casco Viejo, where facials, body scrubs, and massages complement rooftop swimming with city views. Steam room sessions and fitness options round out the rejuvenating experience.
Skilled hands deliver hot stone massages, Swedish treatments, and reflexology at this urban sanctuary. Luxuriate between spa sessions in the outdoor pool, with sun loungers perfectly positioned for sunset views. Comfortable rooms with premium bedding complete the restorative journey.
Aromatherapy sessions and deep-tissue massages await at the full-service Waldorf Astoria Spa. Guests rave about the fantastic hot tub experience and exceptional staff who ensure complete relaxation. After treatments, unwind poolside with refreshments from the bar.
Blissful journeys begin at this spa sanctuary with aromatherapy and Ayurvedic treatments amid luxurious surroundings. After indulging in hydrotherapy or hot stone massages, guests savor excellent cuisine at the highly-rated restaurant, completing a perfect wellness escape.
Full-service spa treatments elevate wellness journeys at this historic Panama hotel. Body wraps, facials, and manicures complement the outdoor pool and 24-hour fitness center. International dining across 5 restaurants satisfies culinary desires after rejuvenating sessions.
Soothing massage treatments await in this tranquil oasis surrounded by tropical gardens and sparkling pools. Guests revitalize with spa services, then unwind at the swim-up bar or enjoy international cuisine at the poolside restaurant. Every detail fosters rejuvenation.
Sona Spa and Wellness offers daily pampering in this upscale retreat with stunning city views. Guests relish the heated indoor pool, sauna, and fitness center while enjoying spacious rooms with premium bedding. Expert staff and delicious breakfast complete this urban sanctuary.
Aromatherapy sessions and deep-tissue massages await at this hotel's full-service spa, complete with couples treatment rooms. Modern guest rooms feature heated floors and premium bedding, while helpful staff ensure a serene retreat in a convenient location.
Massage treatments, body wraps, and facials transform this bayside hotel into a wellness sanctuary. A sun-drenched pool area, sauna, and steam room complement the rejuvenating spa experience, while attentive staff ensure every moment feels indulgent.
Aromatic body treatments and deep-soaking tubs await at The Spa at Bristol, where 6 serene rooms offer couples massages and reflexology. Guests enjoy the sauna, steam room, and outdoor pool before dining at the international restaurant.
Blissful spa sanctuary awaits with deep-tissue massages, rejuvenating facials, and body wraps in dedicated treatment rooms. Unwind in the sauna, hot tub, or hammam after enjoying the outdoor pool with swim-up bar and exceptional dining options.
Rejuvenation awaits at this urban sanctuary featuring 3 inviting hot tubs and professional massage services. Yoga classes and a well-equipped health club complement the serene garden setting, creating a complete wellness retreat amid city conveniences.
Decapolis Spa beckons with specialized massages, aromatherapy, and Ayurvedic treatments in a serene setting. Guests marvel at the steam room, sauna, and Turkish bath while enjoying access to casino excitement, poolside relaxation, and exceptional breakfast service.
Spa indulgence awaits at Hotel El Panama with deep-tissue massages, hot stone treatments, and reflexology in dedicated couples rooms. After unwinding in the sauna and steam room, splash in the stunning outdoor pool before trying luck at the casino.
Aromatic body wraps and revitalizing facials await at Sortis Spa, where 10 treatment sanctuaries promise blissful escape. Beyond spa indulgences, guests savor international cuisine at La Brasserie, unwind by the sun-drenched pool, or try their luck at the lively casino.
Spa enthusiasts discover a wellness sanctuary at this art deco resort where aromatherapy treatments complement a Turkish hammam. Outdoor tennis courts, poolside relaxation, and three dining venues create balance between activity and indulgence.
Aromatherapy sessions and hot stone massages await in the full-service spa featuring couples treatment rooms and a Turkish bath. Golf enthusiasts appreciate the Jack Nicklaus-designed course while others enjoy poolside relaxation with attentive staff always nearby.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Casco Viejo's cobblestone streets tell Panama's colonial story at every turn. The golden Metropolitan Cathedral and historic theaters create a living museum vibe. Rooftop bars offer spectacular bay views while museums showcase Panama's diverse heritage. Plaza hopping rewards you with hidden architectural gems and cultural performances that bring history to life.
The neighborhood serves up everything from fusion cuisine in restored mansions to traditional Panamanian dishes. Boutique hotels occupy colonial buildings with charming courtyards and personalized service. Though compact, comfortable walking shoes are essential for navigating the uneven historic streets.
Bella Vista balances Panama City's sleek business side with upscale urban living. Gleaming skyscrapers along Avenida Balboa house financial headquarters while trendy spots on Calle Uruguay buzz with after-work crowds. Shop at MultiPlaza Pacific mall, visit Crown Casino, or simply stroll the waterfront promenade for stunning bay views.
Getting around is a breeze with two metro stations and plentiful taxis. Dining options range from rooftop restaurants to international cuisine that won't disappoint. High-rise hotels with spectacular views cater to business travelers and tourists who appreciate modern comforts with a side of ocean breeze.
El Cangrejo pulses with modern energy around the iconic "El Tornillo" tower, where art meets business in Panama City's cosmopolitan heart. Korean BBQ aromas mingle with coffee scents from sidewalk cafes, while galleries showcase local talent beneath tropical sunshine. Colorful murals splash across office buildings as diverse cultures blend in this trendy district.
The neighborhood serves up an eclectic fusion of Korean, Jewish, and Panamanian cuisines in stylish eateries and casual cafes. Modern boutique hotels and upscale business lodging dominate accommodation options. Getting around is a breeze with nearby Metro Line 1 stations, abundant taxis, and pleasantly walkable streets.
Obarrio dazzles with gleaming skyscrapers housing Panama City's financial powerhouses and luxury shopping. Multiplaza Pacific mall tempts with designer boutiques while the business crowd buzzes between meetings. When you're not trying your luck at local casinos, relax at a sophisticated coffeehouse or stroll the wide, clean sidewalks of Calle 50.
Hotels range from international chains to boutique properties, with rates reflecting the upscale surroundings. Getting around is a breeze with excellent taxi service, frequent buses along Via España, and the Metro Line 1 connecting directly to Iglesia del Carmen station.
Punta Pacifica's gleaming glass towers and an iconic sail-shaped skyscraper create a skyline that screams luxury with a Pacific Ocean backdrop. Stroll the waterfront promenades where swaying palms frame perfect sunset views, or duck into Multiplaza Pacific Mall to browse designer boutiques in marble-floored splendor. The neighborhood balances business and pleasure with its mix of corporate offices and upscale leisure spots.
Dining here means international cuisine with ocean views at rooftop bars and hotel restaurants where reservations are smart moves. High-rise hotels and serviced apartments offer amenities like infinity pools and concierge services. Getting around is easy with abundant taxis and walkable streets, though you won't find much public transit in this polished enclave.
If you want to give your credit card some exercise, head out to Multiplaza Pacific Mall in San Francisco. Splash some more cash at Avenida Balboa, Multicentro Panama, and Pacific Center.
If you're planning a bit of sightseeing head to Amador Causeway— just one of the monuments in Amador. You can also discover the churches and cathedral in the area— your sightseeing tour starts here. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
If you want to give your credit card some exercise, head out to Avenida Balboa in Calidonia. Splash some more cash at Multicentro Panama, Uruguay Street, and Multiplaza Pacific Mall.
Don't visit Ancon without stopping off at Albrook Shopping Mall, a top spot for shopaholics. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
If you want to give your credit card some exercise, head out to Via Espana in Bella Vista. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. Splash some more cash at Uruguay Street, Multicentro Panama, and Avenida Balboa.
You can stroll along Fuerte Amador Resort & Marina for relaxing water views when you're in Amador. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you carry on walking you'll get to Panama Cruise Terminal for some more water views.
If you want to give your credit card some exercise, head out to El Dorado Mall in Bethania. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
