A calm river surrounded by trees reflecting in the water.

Hotels in O Brien

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Sep 27 - Sep 28

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Where to stay in O Brien?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in O Brien on Hotels.com. These O Brien hotels consistently deliver on quality, location and traveler experience. Last updated on September 27, 2026.

A hotel pool area with lounge chairs and umbrellas, a pool with metal railings, and a building with multiple floors and large windows.

A hotel lobby with a seating area, a television mounted on a wall, and a large window providing a view of the outdoors.

An outdoor patio area with tables and chairs, surrounded by a metal fence, and umbrellas providing shade.

A Hampton Inn & Suites hotel with a modern design, featuring a prominent red sign, a covered entrance, and a parking area.

1. Hampton Inn & Suites Lake City

Lake City

CNY704

CNY792 total

includes taxes & fees

Oct 4 - Oct 5

A spacious living area with a grey sofa, a coffee table, and a TV stand.

A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

A modern kitchen with light wood cabinets, granite countertops, and stainless steel appliances. There are signs on the wall advertising different coffee brands.

A hotel room with two beds, a desk, a TV, and a large window with curtains.

2. Best Western Plus Lake City

Lake City

CNY549

CNY617 total

includes taxes & fees

Sep 30 - Oct 1

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

A modern kitchen area with a coffee station, including a coffee machine, cups, and a toaster.

A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.

A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.

3. La Quinta Inn & Suite by Wyndham Lake City

Lake City

CNY604

CNY680 total

includes taxes & fees

Sep 30 - Oct 1

A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.

A modern hotel with a flat roof, multiple windows, and a covered entrance.

A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.

A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

4. Tru by Hilton Lake City

Lake City

CNY651

CNY733 total

includes taxes & fees

Oct 4 - Oct 5

An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.

A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.

5. Fairfield Inn & Suites Lake City

Lake City

CNY631

CNY710 total

includes taxes & fees

Oct 4 - Oct 5

A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.

A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.

6. Americas Best Value Inn Lake City

Lake City

CNY434

CNY488 total

includes taxes & fees

Sep 28 - Sep 29

A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.

A reception area with a counter, a coffee machine, and a potted plant.

A white building with multiple windows and a sign that reads 'Quality Inn.'

7. Quality Inn Lake City

Lake City

CNY536

CNY603 total

includes taxes & fees

Oct 28 - Oct 29

A covered outdoor area with a paved walkway, benches, and potted plants.

A compact kitchen with a blue refrigerator, a black coffee maker, a microwave, and a small black refrigerator.

A bedroom with a bed, a desk, a chair, and a ceiling fan.

A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.

8. Cindys Motel

Mayo

CNY589

CNY637 total

includes taxes & fees

Sep 29 - Sep 30

An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

A modern hotel lobby with a reception desk, seating areas, and a large screen.

A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.

9. Home2 Suites by Hilton Lake City

Lake City

CNY736

CNY828 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

An aerial view of a hotel with a swimming pool, parking lot, and surrounding greenery.

A swimming pool with lounge chairs and umbrellas, surrounded by a brick building with balconies and palm trees.

10. Super 8 by Wyndham Lake City

Lake City

CNY439

CNY494 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

A modern hotel lobby with a central island table, seating area with chairs, a fireplace, and a bar area.

A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

A modern hotel lobby with a fireplace, seating areas, and a bar.

11. Comfort Suites Lake City

Lake City

CNY625

CNY703 total

includes taxes & fees

Oct 6 - Oct 7

A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.

A reception desk with a Holiday Inn sign, two computer monitors, and a security camera.

A hotel lobby with multiple seating areas, a bar, and an elevator.

A hotel room with two beds, a TV, a desk with a lamp, and a window with blinds.

12. Holiday Inn & Suites Lake City by IHG

Lake City

CNY678

CNY763 total

includes taxes & fees

Oct 4 - Oct 5

A two-story building with a covered porch and a staircase leading to the upper level.

13. Suwannee River Retreat: Pet Friendly, Private Dock

Branford

CNY2,162

CNY4,070 total

includes taxes & fees

Sep 28 - Sep 29

An outdoor patio area with wicker chairs, a round table, and a fire pit.

A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.

A modern interior with a central kitchen area, a seating area with a sofa and chairs, and a large window providing natural light.

A modern interior with a sofa, round tables, and chairs, a TV mounted on the wall, and a patterned wall.

14. TownePlace Suites by Marriott Lake City

Lake City

CNY866

CNY974 total

includes taxes & fees

Sep 28 - Sep 29

A modern restaurant with a central counter, red chairs, and a blue and white color scheme.

A hotel room with a bed, a desk with a coffee maker, a chair, and a lamp.

A hotel with a covered entrance, a sign indicating it is a Holiday Inn Express, and a well-maintained lawn area.

A conference room with a stone fireplace, a flat-screen TV, and two office chairs.

15. Holiday Inn Express & Suites Live Oak by IHG

Live Oak

CNY765

CNY842 total

includes taxes & fees

Oct 18 - Oct 19

A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

A hotel lobby with a dining area, a reception desk, and a view of the outside.

A reception area with a tiled counter, a computer, a sign reading 'Quality,' and two decorative vases.

A hotel room with a bed, desk, chair, and sofa.

16. Quality Inn White Springs Suwanee

White Springs

CNY449

CNY494 total

includes taxes & fees

Sep 29 - Sep 30

A commercial kitchen with coffee machines, a beverage dispenser, and various kitchen appliances.

A modern bathroom with a double sink, a mirror with integrated lighting, a towel rack, and a shelf with neatly folded towels.

A hotel room with two beds, a nightstand with a lamp, and a small table with a phone and a clock.

A rectangular swimming pool with a safety ladder, surrounded by a low hedge and palm trees.

17. Quality Inn & Suites Live Oak I-10 Exit 283

Live Oak

CNY569

CNY626 total

includes taxes & fees

Oct 4 - Oct 5

A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.

A breakfast bar with a coffee machine, a microwave, and a sign reading "Breakfast Corner." There are several wooden tables and chairs arranged around the bar.

A pool area with a fenced deck, palm trees, and a small building with a red roof.

A gazebo with a red roof and green walls, surrounded by trees and a pool.

18. Baymont by Wyndham Lake City I-75

Lake City

CNY388

CNY437 total

includes taxes & fees

Sep 28 - Sep 29

A hotel room with two beds, a desk, a chair, a sink, and a painting of a pier and sunset.

A bathroom with a sink, mirror, towel rack, and a microwave.

A restaurant with a counter, chairs, and a tiled floor.

A reception area with a black counter, a desk, a chair, a potted plant, and a door.

19. Days Inn by Wyndham Lake City I-10

Lake City

CNY422

CNY475 total

includes taxes & fees

Sep 30 - Oct 1

A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

A reception area with two wooden reception desks, a wall-mounted decorative piece, and a refrigerator stocked with beverages.

A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.

20. Courtyard By Marriott Lake City

Lake City

CNY719

CNY809 total

includes taxes & fees

Oct 4 - Oct 5

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Go beyond your typical stay in O Brien

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Learn more about O Brien

O Brien is well-known for its attractions such as Suwannee River and Ichetucknee River.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Check out reviews of O Brien hotels guests love

A modern kitchen with a flat-screen TV, a microwave, and a coffee maker on a wooden cabinet. There is a window with a view of a green landscape.

A living room with a grey sofa, a wooden coffee table, and a framed horse picture on the wall.

A narrow kitchen with a wooden ceiling, a green refrigerator, and a wooden countertop.

Vista Verde Farm Retreat

Lake City

10/10 Exceptional

United States

Julio César

A spacious indoor dining area with multiple tables and chairs, large windows offering a view of palm trees and greenery outside.

A hotel room with a bed, a desk with a chair, a television, and a blue sofa.

A lobby with a patterned carpet, two green armchairs, a white sofa, a small round table with a plant, and framed artwork on the wall.

A Holiday Inn Express & Suites hotel with a modern design, multiple floors, and a parking lot.

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

10/10 Exceptional

United States

Enid

An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.

A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.

Fairfield Inn & Suites Lake City

Lake City

10/10 Exceptional

United States

Steven

A modern kitchen area with a central counter, various food stations, and a chalkboard menu.

A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

A hotel room with two beds, a desk, a chair, a TV, and a couch.

Hampton Inn & Suites Alachua I-75

Alachua

10/10 Exceptional

United States

Jose

A spacious living area with a large chandelier, a sofa set, a coffee table, and a patterned floor.

A storefront with a glass door and a brick wall. The sign above the door reads "The Blanche."

A spacious hotel lobby with high ceilings, chandeliers, and a central round table.

A hotel with a classic facade, featuring a prominent sign reading "HOTEL BLANCHE".

The Blanche

Lake City

10/10 Exceptional

United States

John

A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.

A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.

Americas Best Value Inn Lake City

Lake City

10/10 Exceptional

United States

Nathaly

A hotel room with two beds, a blue wall, and a window with curtains.

A bathroom with a beige sink, a large mirror, and a white trash bin.

A modern kitchen with a built-in stove, a coffee machine, and a sink. There is a trash can and a potted plant near the sink.

Gateway Inn

Lake City

10/10 Exceptional

United States

Hugo

An aerial view of a campground with RVs, a swimming pool, and tennis courts.

A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.

A wooden cabin with a porch, a front door, and a small window.

A wooden cabin with a kitchen, a bathroom, and a loft bedroom.

Suwannee River Rendezvous

Mayo

10/10 Exceptional

United States

Beth

A spacious living area with a grey sofa, a coffee table, and a TV stand.

A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

A modern kitchen with light wood cabinets, granite countertops, and stainless steel appliances. There are signs on the wall advertising different coffee brands.

A hotel room with two beds, a desk, a TV, and a large window with curtains.

Best Western Plus Lake City

Lake City

10/10 Exceptional

United States

waqar

A hotel pool area with lounge chairs and umbrellas, a pool with metal railings, and a building with multiple floors and large windows.

A hotel lobby with a seating area, a television mounted on a wall, and a large window providing a view of the outdoors.

An outdoor patio area with tables and chairs, surrounded by a metal fence, and umbrellas providing shade.

A Hampton Inn & Suites hotel with a modern design, featuring a prominent red sign, a covered entrance, and a parking area.

Hampton Inn & Suites Lake City

Lake City

10/10 Exceptional

United States

Strother

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

A modern kitchen area with a coffee station, including a coffee machine, cups, and a toaster.

A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.

A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.

La Quinta Inn & Suite by Wyndham Lake City

Lake City

10/10 Exceptional

United States

Christopher

A hotel reception area with a reception desk, seating area, and a view of the parking lot.

A compact room with a flat-screen TV on a wooden cabinet, a microwave on a small black stand, a chair, and a mirror with a light above it.

A reception area with a wooden floor, a reception desk, a seating area with chairs, and a view through the glass doors to the outside.

A dining area with wooden chairs and tables, a coffee machine, and a counter with various items.

Econo Lodge Live Oak

Live Oak

10/10 Exceptional

United States

Stephen

An outdoor patio area with wicker chairs, a round table, and a fire pit.

A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.

A modern interior with a central kitchen area, a seating area with a sofa and chairs, and a large window providing natural light.

A modern interior with a sofa, round tables, and chairs, a TV mounted on the wall, and a patterned wall.

TownePlace Suites by Marriott Lake City

Lake City

10/10 Exceptional

United States

Penny

A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.

A modern hotel with a flat roof, multiple windows, and a covered entrance.

A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.

A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

Tru by Hilton Lake City

Lake City

10/10 Exceptional

United States

Richard

A cabin with a cozy interior, a dining area, and a view of the forest.

A cozy cabin interior with a wooden interior, a dining table with a chair, a window, and a hanging lantern.

A bedroom with a wooden headboard, a bed with white linens, a window with a view of green foliage, and a tray with breakfast items.

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

High Springs

10/10 Exceptional

United States

Alexander

A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.

A small building with a green roof, a covered porch with wicker chairs, and a table.

A bedroom with a bed, a chair, a dresser, a ceiling fan, a window with blinds, and a wall-mounted air conditioner.

A stone outdoor seating area with a table and benches, a trash bin, and a building in the background.

High Springs Country Inn

High Springs

10/10 Exceptional

United States

Patrick

A stone water feature with cascading water, surrounded by a brick wall and greenery.

A reception desk with a modern design, a ceiling fan, and a seating area with chairs and a table.

A spacious living area with a wooden floor, a blue sofa, a round coffee table, and a ceiling fan.

A neatly arranged bedroom with a bed, bedside lamps, a TV, and a mirror.

BlueGem Motel

High Springs

10/10 Exceptional

United States

Tina

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