Hotels logo

Hotels in Panacea

October 2026
12
November 2026

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Where to stay in Panacea?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Panacea on Hotels.com. These Panacea hotels consistently deliver on quality, location and traveler experience. Last updated on October 13, 2026.
A pink door with a window, set in a corrugated metal exterior with wooden trim.
A wooden bench in a natural setting with trees and a body of water in the background.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, a stove, and a sink. There are wooden shelves above the counter and a window with a view.
A kitchen with a wooden countertop, a built-in sink, and a trash can.

1. The Panacea Motel

The Panacea Motel
Panacea
CNY797
CNY889 total
includes taxes & fees
Oct 13 - Oct 14
The Panacea Motel
A fountain with a dolphin statue in a courtyard, surrounded by buildings with arched windows and a pool with blue mosaic tiles.
A modern hotel lobby with a sofa, armchairs, a desk, and a TV.
A hotel with a covered patio, outdoor seating, and a central pathway leading to the entrance.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

2. Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville
CNY723
CNY806 total
includes taxes & fees
Oct 26 - Oct 27
Best Western Wakulla Inn & Suites
A spacious indoor area with tiled flooring, multiple tables and chairs, a stone fireplace, and a glass door entrance.
A stone fireplace with a painting above it, wooden walls, a dining area with chairs, and a view of parked cars through large windows.
A hotel room with a bed, a desk, a chair, a small table with a vase, a trash bin, and a wooden door.
Fitness facility

3. Wildwood Inn

Wildwood Inn
Crawfordville
CNY795
CNY914 total
includes taxes & fees
Nov 5 - Nov 6
Wildwood Inn
A spacious lobby with leather sofas, a coffee table, and a large window with arched frames.
A courtyard with a central fountain, surrounded by well-maintained hedges and trees.
A boat docked at a pier with passengers on board.
A spacious lobby with high ceilings, ornate ceiling decorations, and large windows.

4. The Lodge at Wakulla Springs

The Lodge at Wakulla Springs
Crawfordville
CNY757
CNY844 total
includes taxes & fees
Oct 18 - Oct 19
The Lodge at Wakulla Springs
A bar area with a long counter, stools, and a variety of bottles and glasses.
A living room with a sofa set, a television, and a ceiling fan.
A swimming pool with lounge chairs, palm trees, and a clear blue sky.
A multi-story hotel with a reflective water body in front, surrounded by greenery and a golf course.

5. St James Bay Golf & Pickleball Resort

St James Bay Golf & Pickleball Resort
Carrabelle
CNY837
CNY1,177 total
includes taxes & fees
Oct 13 - Oct 14
St James Bay Golf & Pickleball Resort
A marina with boats docked, a small building, and a clear sky.
A spacious room with a pool table, a round dining table with chairs, and large windows offering a view of a body of water.
A pool area with a table and chairs, a building with doors, and a palm tree.
A spacious room with a pool table, a billiards table, and a dining area with chairs and a table.

6. The Moorings Hotel and Marina

The Moorings Hotel and Marina
Carrabelle
CNY1,208
CNY1,335 total
includes taxes & fees
Oct 13 - Oct 14
The Moorings Hotel and Marina
A covered patio with a table and chairs, a wooden ceiling fan, and a view of the surrounding greenery.
A yellow door with a window, a potted plant, a white wall-mounted light fixture, and a staircase with yellow curtains.
A hotel with a white facade, red accents, and a sign indicating it is the Old Carrabelle Hotel.
A bedroom with a wooden four-poster bed, a ceiling fan, a bookshelf, and a wall-mounted lamp.

7. The Old Carrabelle Hotel

The Old Carrabelle Hotel
Carrabelle
CNY663
CNY732 total
includes taxes & fees
Oct 13 - Oct 14
The Old Carrabelle Hotel
A hotel room with two beds, a nightstand, a lamp, and a bathroom visible through an open door.
A motel with a single-story structure, a covered parking area, and a palm tree in front.
A motel with a row of rooms, a staircase, and a parking area.
A bathroom with a toilet, shower, and sink with a marble countertop.

8. Franklin Inn

Franklin Inn
Carrabelle
CNY629
CNY695 total
includes taxes & fees
Oct 13 - Oct 14
Franklin Inn
View all properties

Get last-minute hotel deals in Panacea and save more

Sign in to unlock great savings.
A pink door with a window, set in a corrugated metal exterior with wooden trim.
A wooden bench in a natural setting with trees and a body of water in the background.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, a stove, and a sink. There are wooden shelves above the counter and a window with a view.
A kitchen with a wooden countertop, a built-in sink, and a trash can.

The Panacea Motel

The Panacea Motel
Panacea
We have 1 left at
CNY990
per night
CNY2,208 total
includes taxes & fees
The Panacea Motel
A modern kitchen with white cabinets, stainless steel appliances, and a dining area with wooden chairs and a table.
A covered porch with wicker furniture and a brick wall.
A living room with a wooden ceiling, a television, a green armchair, a sofa, and a coffee table.
A modern kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a coffee maker.

2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!

2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!
Panacea
We have 1 left at
CNY1,051
per night
CNY4,123 total
includes taxes & fees
2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!
A beach with wooden chairs and a table, overlooking the ocean.
A spacious living room with a large beige sectional sofa, a flat-screen TV mounted on the wall, and a ceiling fan.
A kitchen with a sink, countertop, and a view of the outside. There is a dining area with a table and chairs.
A kitchen with a dining table set for a meal, a hanging light fixture, and a view of the outdoors through large windows.

Waterfront Panacea Vacation Rental w/ Dock!

Waterfront Panacea Vacation Rental w/ Dock!
Panacea
We have 1 left at
CNY1,620
per night
CNY4,707 total
includes taxes & fees
Waterfront Panacea Vacation Rental w/ Dock!
A modern kitchen with a central island, bar stools, and pendant lighting.
A wooden deck with a white railing, a covered porch area, and a view of palm trees and greenery.
A two-story house with a covered porch and a staircase leading to the upper level.
A modern kitchen with a wooden table, stainless steel appliances, and a ceiling light fixture.

Nature Lover's Paradise: Hike, Bike & Fish!

Nature Lover's Paradise: Hike, Bike & Fish!
Panacea
We have 1 left at
CNY1,292
per night
CNY5,569 total
includes taxes & fees
Nature Lover's Paradise: Hike, Bike & Fish!
A wooden boardwalk surrounded by lush green vegetation and tall trees.
A green building with a small outdoor sink and a window vent.
A swimming pool with a wooden deck, lounge chairs, and umbrellas.
A sandy beach with a clear sky and a few clouds.

Breezy Home w/ Grills, Pool & Beach Access!

Breezy Home w/ Grills, Pool & Beach Access!
Panacea
We have 1 left at
CNY1,827
per night
CNY5,847 total
includes taxes & fees
Breezy Home w/ Grills, Pool & Beach Access!
A deck with two rocking chairs and a striped chair, overlooking the ocean.
A dining area with a table set for four, large windows, a ceiling fan, and a view of the ocean.
Interior
Interior

Alligator Point Beachfront Home w/ Private Hot Tub

Alligator Point Beachfront Home w/ Private Hot Tub
Panacea
We have 1 left at
CNY2,450
per night
CNY7,675 total
includes taxes & fees
Alligator Point Beachfront Home w/ Private Hot Tub

Go beyond your typical stay in Panacea

pet friendly image
Pet friendly
Pet friendly
Pool image
Pool
Pool
Cottage image
Cottage
Cottage
Apartment image
Apart­ment
Apart­ment
spa image
Spa
Spa
Family friendly image
Family friendly
Family friendly
Our prices for hotels in Panacea are cheapest in February

Price trends for hotels in Panacea

Pricing is based on two traveler single night rates
View properties in October

October

High 27°C / low 18°C. Sunny most days.
27°
18°
22°
13°
19°
11°
17°
8°
19°
10°
22°
13°
25°
16°
29°
20°
31°
23°
32°
24°
32°
25°
30°
23°
Monthly weather averages (˚C)

Top landmarks in Panacea

Alligator Point Beach

8.8/10 (10 reviews)
When the beach is calling your name, you might want to head down to Alligator Point Beach, located 4.5 mi (7.2 km) from central Alligator Point. Enjoy the sunset by the shore at Wilson Beach.
See properties

Bald Point State Park

8.6/10 (20 reviews)
Bald Point State Park is 1.7 mi (2.7 km) from central Alligator Point, why not stop by during your stay.
See properties

Mashes Sand Beach

8.8/10 (3 reviews)
If being by the water is a major draw, Mashes Sand Beach is a spot you might want to check out, located 5.1 mi (8.2 km) from central Panacea. If you want to continue walking by the waves, head to Shell Point Beach, Wilson Beach, and Alligator Point Beach.
See properties

Public Beach Access

Public Beach Access is 2.3 mi (3.7 km) from central Alligator Point, why not stop by during your stay. Want to stretch your legs some more? Head to Alligator Harbor Aquatic Preserve, located nearby.
See properties

beach near Alligator Point Marina

When the beach is calling your name, you might want to head down to beach near Alligator Point Marina, located 3 mi (4.8 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
See properties

Wilson Beach

Whether you want to collect beach glass or watch the sunset, Wilson Beach is a spot you might want to check out, located 7.4 mi (11.9 km) from central Panacea. Enjoy the sunset by the shore at Alligator Point Beach.
See properties

beach near Alligator Point

When the beach is calling your name, you might want to head down to beach near Alligator Point, located 2.7 mi (4.4 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
See properties

beach near Southern Dunes

If want to top up your tan, you might want to head out to beach near Southern Dunes, located 1.7 mi (2.8 km) from central Alligator Point. Enjoy the sunset by the shore at Mashes Sand Beach.
See properties

Learn more about Panacea

Notable for its natural beauty, Panacea features attractions such as Mashes Sand Beach and Alligator Point Beach. This beachside city has something for everyone including seafood restaurants as well as sights like Bald Point State Park and Wilson Beach. All are within a secluded setting.

See all hotels in Panacea
A coastal resort with beachfront villas and a clear blue sky.

Check out reviews of Panacea hotels guests love

A fountain with a dolphin statue in a courtyard, surrounded by buildings with arched windows and a pool with blue mosaic tiles.
A modern hotel lobby with a sofa, armchairs, a desk, and a TV.
A hotel with a covered patio, outdoor seating, and a central pathway leading to the entrance.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville

10/10 Exceptional

United States
Paul
Best Western Wakulla Inn & Suites
A spacious indoor area with tiled flooring, multiple tables and chairs, a stone fireplace, and a glass door entrance.
A stone fireplace with a painting above it, wooden walls, a dining area with chairs, and a view of parked cars through large windows.
A hotel room with a bed, a desk, a chair, a small table with a vase, a trash bin, and a wooden door.
Fitness facility

Wildwood Inn

Wildwood Inn
Crawfordville

10/10 Exceptional

United States
Marilou
Wildwood Inn
A bar area with a long counter, stools, and a variety of bottles and glasses.
A living room with a sofa set, a television, and a ceiling fan.
A swimming pool with lounge chairs, palm trees, and a clear blue sky.
A multi-story hotel with a reflective water body in front, surrounded by greenery and a golf course.

St James Bay Golf & Pickleball Resort

St James Bay Golf & Pickleball Resort
Carrabelle

10/10 Exceptional

United States
Nancy
St James Bay Golf & Pickleball Resort
A marina with boats docked, a small building, and a clear sky.
A spacious room with a pool table, a round dining table with chairs, and large windows offering a view of a body of water.
A pool area with a table and chairs, a building with doors, and a palm tree.
A spacious room with a pool table, a billiards table, and a dining area with chairs and a table.

The Moorings Hotel and Marina

The Moorings Hotel and Marina
Carrabelle

10/10 Exceptional

United States
Tuledo
The Moorings Hotel and Marina
A hotel room with two beds, a nightstand, a lamp, and a bathroom visible through an open door.
A motel with a single-story structure, a covered parking area, and a palm tree in front.
A motel with a row of rooms, a staircase, and a parking area.
A bathroom with a toilet, shower, and sink with a marble countertop.

Franklin Inn

Franklin Inn
Carrabelle

10/10 Exceptional

United States
Marla
Franklin Inn

Frequently Asked Questions

How much does a hotel room cost in Panacea?

You can find top hotels in Panacea from CNY629 with options to suit your budget and needs. If you're looking for an affordable hotel in Panacea that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Panacea hotels?

Discover great deals on Panacea hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on Panacea hotels.

Can I book Panacea hotels with free cancellation?

To book a refundable Panacea hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

Keep exploring