Hotels in East Prairie

Q: What hotels do travelers like in East Prairie?

Guests like Quality Inn Charleston - Sikeston .

Where to?

Dates

March 2026

4

April 2026

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Where to stay in East Prairie?

Suite, 2 Queen Beds, Non Smoking | Individually furnished, desk, laptop workspace, blackout drapes

MainStay Suites Union City, TN

Union City

Comfortable Union City stay with fitness center and hiking trails nearby.

CNY895 total

includes taxes & fees

Mar 15 - Mar 16

Sleep Inn at Discovery Park of America

Union City

Wake up to historic adventure at this convenient Union City hotel near Discovery Park.

CNY621 total

includes taxes & fees

Mar 15 - Mar 16

Hospitality House Union City I 69 / US 51

Union City

Modern comfort near County Market Place with outdoor pool and dining options.

CNY500 total

includes taxes & fees

Mar 18 - Mar 19

Holiday Inn Express & Suites Union City by IHG

Union City

Take a morning dip in the indoor pool, steps from entertainment district.

CNY920 total

includes taxes & fees

Mar 15 - Mar 16

Country Hearth Inn & Suites Union City

Union City

Cozy Union City motel with free breakfast, WiFi, and nearby shopping convenience.

CNY591 total

includes taxes & fees

Mar 15 - Mar 16

Hampton Inn Union City

Union City

Relax in Union City at this cozy hotel with an indoor pool and fitness center.

CNY943 total

includes taxes & fees

Mar 15 - Mar 16

Quality Inn Union City US 51

Union City

Charming Union City stay with outdoor pool and hot tub for relaxation.

CNY588 total

includes taxes & fees

Mar 15 - Mar 16

Quality Inn Cairo I-57

Cairo

Convenient Cairo hotel offers comfortable stay with free breakfast and WiFi.

CNY553 total

includes taxes & fees

Mar 17 - Mar 18

Room, 1 King Bed, Non Smoking | View from room

Eagle Inn Charleston

Charleston

Stay fit while visiting Charleston with a health club at this convenient motel.

CNY4,214 total

includes taxes & fees

Apr 3 - Apr 4

Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

Gateway to historic Charleston with easy interstate access and free breakfast.

CNY615 total

includes taxes & fees

Apr 3 - Apr 4

The Riverstone Hotel Charleston-Sikeston

Charleston

CNY768 total

includes taxes & fees

Apr 3 - Apr 4

Standard Room, 2 Double Beds, Non Smoking | Blackout drapes, iron/ironing board, free WiFi, bed sheets

Reelfoot Lake Inn

Tiptonville

CNY553 total

includes taxes & fees

Mar 20 - Mar 21

Iron/ironing board, free WiFi, bed sheets

Country Yard Inn and Suite

Sikeston

Enjoy a comfortable base in Sikeston with free perks and 24-hour service.

CNY440 total

includes taxes & fees

Apr 3 - Apr 4

1 bedroom, desk, laptop workspace, blackout drapes

Days Inn and Suites by Wyndham Sikeston

Sikeston

Enjoy a peaceful night's rest and complimentary breakfast at this quiet Sikeston hotel.

CNY637 total

includes taxes & fees

Apr 4 - Apr 5

Best Western Plus Sikeston I-55

Sikeston

Stay minutes from Central Park at this inviting hotel with an indoor pool and gym.

CNY694 total

includes taxes & fees

Apr 4 - Apr 5

Drury Inn & Suites Sikeston, MO

Sikeston

Peaceful highway-adjacent retreat with indoor and outdoor pool options.

CNY748 total

includes taxes & fees

Mar 29 - Mar 30

Individually decorated, individually furnished, desk, blackout drapes

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Enjoy a serene stay in Sikeston, just minutes from Central Park and Depot Museum.

CNY540 total

includes taxes & fees

Apr 3 - Apr 4

Desk, free WiFi, bed sheets, alarm clocks

Comfort Inn & Suites Sikeston I-55

Sikeston

Cozy stay near Central Park with indoor pool, free WiFi, and friendly staff.

CNY837 total

includes taxes & fees

Apr 3 - Apr 4

Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Convenient stay near Central Park with refreshing pool and complimentary perks.

CNY728 total

includes taxes & fees

Mar 22 - Mar 23

Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi

Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Convenient Sikeston escape with free amenities and easy access to local attractions.

CNY674 total

includes taxes & fees

Apr 3 - Apr 4

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Go beyond your typical stay in East Prairie

Family friendly

Pool

Top landmarks in East Prairie

Big Oak Tree State Park

3.8/5 (8 reviews)

Big Oak Tree State Park is 10.3 mi (16.6 km) from central East Prairie, why not stop by during your stay.

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Learn more about East Prairie

East Prairie is well-known for its attractions such as Big Oak Tree State Park and Mississippi River.

See all hotels in East Prairie

The Mississippi River near Hannibal, Missouri, USA

Check out reviews of East Prairie hotels guests love

Quality Inn Union City US 51

8/10 Good

"All was pretty good except for the breakfast."

Frequently asked questions

How much does a hotel room cost in East Prairie?

You can choose a great hotel in East Prairie from CNY440 with properties to suit all budgets and needs. To find an affordable hotel in East Prairie that meets all of your requirements, just apply filters on Hotels.com and sort hotels by "Price: low to high".

How can I find deals and earn rewards at East Prairie hotels?

Discover great deals on East Prairie hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on East Prairie hotels.

Can I book East Prairie hotels with free cancellation?

It's easy to book a refundable East Prairie hotel on Hotels.com. Simply filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What hotels do travelers like in East Prairie?

Guests like Quality Inn Charleston - Sikeston.

Can I book a refundable hotel in East Prairie?

If you need the flexibility to change your travel plans to East Prairie, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in East Prairie be like during my trip?

July and August are typically the warmest months in East Prairie when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. March and April are the months with the most rain.

Why should I book my East Prairie accommodation with Hotels.com?

There are lots of reasons to book your East Prairie trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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