If you're looking for a place to get away, look no further than East Prairie. Whether you're planning to stay for a night or for the week, the area around East Prairie has accommodations to fit every need. Search for hotels in East Prairie with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all East Prairie hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best East Prairie hotel deals are here with our lowest price guarantee.
Hotels in East Prairie
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Where to stay in East Prairie?

Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
6.8 out of 10, (389)
The price is CNY504
CNY560 total
includes taxes & fees
Jul 27 - Jul 28

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 out of 10, (572)
The price is CNY471
CNY523 total
includes taxes & fees
Jul 27 - Jul 28

Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (100)
The price is CNY473
CNY525 total
includes taxes & fees
Jul 16 - Jul 17

Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
7.2 out of 10, Good, (1001)
The price is CNY579
CNY660 total
includes taxes & fees
Jul 28 - Jul 29

Best Western Plus Sikeston
Best Western Plus Sikeston
8.4 out of 10, Very Good, (1011)
The price is CNY632
CNY720 total
includes taxes & fees
Aug 10 - Aug 11

Country Yard Inn and Suite
Country Yard Inn and Suite
7.2 out of 10, Good, (97)
The price is CNY465
CNY553 total
includes taxes & fees
Jul 16 - Jul 17

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
8.4 out of 10, Very Good, (661)
The price is CNY506
CNY576 total
includes taxes & fees
Jul 16 - Jul 17

Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
8.4 out of 10, Very Good, (268)
The price is CNY639
CNY728 total
includes taxes & fees
Aug 10 - Aug 11

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1005)
The price is CNY678
CNY779 total
includes taxes & fees
Jul 19 - Jul 20

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
9.4 out of 10, Exceptional, (1006)
The price is CNY731
CNY841 total
includes taxes & fees
Aug 3 - Aug 4

Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
6.6 out of 10, (543)
The price is CNY477
CNY543 total
includes taxes & fees
Jul 28 - Jul 29

Hampton Inn Sikeston
Hampton Inn Sikeston
8.8 out of 10, Excellent, (361)
The price is CNY847
CNY959 total
includes taxes & fees
Jul 28 - Jul 29

Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
8.6 out of 10, Excellent, (412)
The price is CNY774
CNY877 total
includes taxes & fees
Jul 20 - Jul 21

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott Sikeston
10.0 out of 10, Exceptional, (14)
The price is CNY875
CNY990 total
includes taxes & fees
Jul 21 - Jul 22

TownePlace Suites by Marriott Sikeston
TownePlace Suites by Marriott Sikeston
7.4 out of 10, Good, (3)
The price is CNY961
CNY1,088 total
includes taxes & fees
Jul 27 - Jul 28

Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, (260)
The price is CNY539
CNY598 total
includes taxes & fees
Jul 28 - Jul 29

Super 8 By Wyndham Marston
Super 8 By Wyndham Marston
8.0 out of 10, Very Good, (23)
The price is CNY687
CNY785 total
includes taxes & fees
Jul 20 - Jul 21

Travel Inn
Travel Inn
5.8 out of 10, (105)

Reelfoot Lake Inn
Reelfoot Lake Inn
7.2 out of 10, Good, (443)
The price is CNY437
CNY1,175 total
includes taxes & fees
Aug 1 - Aug 2

Sleep Inn at Discovery Park of America
Sleep Inn at Discovery Park of America
9.0 out of 10, Wonderful, (247)
The price is CNY708
CNY841 total
includes taxes & fees
Aug 14 - Aug 15
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in East Prairie
Family friendly
Top landmarks in East Prairie
Big Oak Tree State Park
Big Oak Tree State Park is 10.3 mi (16.6 km) from central East Prairie, why not stop by during your stay.
Learn more about East Prairie
East Prairie is well-known for its attractions such as Big Oak Tree State Park and Mississippi River.
Check out reviews of East Prairie hotels guests love
Fairfield by Marriott Inn & Suites Sikeston
10/10 Excellent
Frequently asked questions
Find out more about East Prairie
Find out more about East Prairie
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