Hotels in East Prairie

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Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in East Prairie on Hotels.com. These East Prairie hotels consistently deliver on comfort, location and traveler experience. Last updated on .

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,000 reviews)
Escape to this serene Sikeston hotel with both indoor and outdoor pools near restaurants and shopping. The fitness center, free breakfast, WiFi and parking enhance your stay, while the helpful staff ensures comfort just minutes from Central Park.
The price is CNY744
CNY855 total
includes taxes & fees
Jun 21 - Jun 22
Drury Inn & Suites Sikeston, MO

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (469 reviews)
Experience Sikeston from this hotel with free breakfast, WiFi, and parking. Take a morning dip in the indoor pool or hit the fitness center. Near Central Park and Sikeston Depot Museum, guests love the helpful staff and clean rooms.
The price is CNY723
CNY819 total
includes taxes & fees
Jun 28 - Jun 29
Holiday Inn Express & Suites Sikeston Southwest by IHG

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (416 reviews)
The price is CNY507
CNY562 total
includes taxes & fees
Jul 9 - Jul 10
The Riverstone Hotel Charleston-Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (578 reviews)
Dive into vacation mode at this welcoming hotel with an indoor pool and fitness center near Central Park. After enjoying the complimentary breakfast, explore Sikeston Depot Museum before returning to relax in modern rooms with free WiFi.
The price is CNY710
CNY804 total
includes taxes & fees
Jul 19 - Jul 20
Hampton Inn Sikeston

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (772 reviews)
Escape to this welcoming Portageville inn where attentive staff are available around the clock. Enjoy clean, comfortable rooms, complimentary WiFi, and free parking throughout your stay. A convenient base for exploring the region, just under an hour from Cape Girardeau.
The price is CNY383
CNY414 total
includes taxes & fees
Jun 21 - Jun 22
New Orleans Inn Portageville

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (92 reviews)
Located in Sikeston, this hotel offers free breakfast, WiFi, and parking. Take a refreshing swim in the indoor pool or grab a bite at the restaurant. Nearby attractions include Central Park and Sikeston Depot Museum for local exploration.
The price is CNY744
CNY842 total
includes taxes & fees
Jun 25 - Jun 26
Fairfield Inn & Suites by Marriott Sikeston

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very Good, (64 reviews)
Discover comfort at this Marston hotel, just off Interstate 55. Wake up to a complimentary full breakfast before exploring nearby attractions. Free WiFi and parking add value to your stay in this convenient Missouri location.
The price is CNY560
CNY639 total
includes taxes & fees
Jun 19 - Jun 20
Super 8 By Wyndham Marston

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,013 reviews)
Experience comfort at this Sikeston hotel, offering free breakfast and parking close to Central Park. The helpful staff welcomes guests to enjoy the indoor pool and fitness center. With easy access to Sikeston Depot Museum, you'll find everything needed for a convenient Missouri stay.
The price is CNY562
CNY641 total
includes taxes & fees
Jul 19 - Jul 20
Best Western Plus Sikeston I-55

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very Good, (525 reviews)
This Quality Inn offers a seasonal outdoor pool, rejuvenating hot tub, and complimentary breakfast near County Market Place. With free WiFi, parking, and easy access to Reelfoot Shopping Center, travelers appreciate the attentive staff.
The price is CNY419
CNY498 total
includes taxes & fees
Jul 1 - Jul 2
Quality Inn Union City US 51

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (571 reviews)
Inviting comfort awaits at this Union City motel where complimentary continental breakfast starts your day. Located near County Market Place and Reelfoot Shopping Center, enjoy free WiFi and parking with attentive staff ready to assist you.
The price is CNY426
CNY505 total
includes taxes & fees
Jun 27 - Jun 28
Country Hearth Inn & Suites Union City

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (399 reviews)
Slip into this inviting Union City hotel just minutes from Discovery Park of America's interactive exhibits. After exploring nearby attractions, unwind in the refreshing indoor pool or maintain your routine in the 24-hour fitness center. Free breakfast, WiFi and parking enhance your value-packed stay.
The price is CNY535
CNY636 total
includes taxes & fees
Jul 12 - Jul 13
Sleep Inn at Discovery Park of America

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (641 reviews)
This Charleston motel offers complimentary WiFi, parking, and on-the-go breakfast daily. Located with convenient interstate access to Cape Girardeau, guests consistently praise the helpful staff. The comfortable accommodations provide a practical base for exploring southeastern Missouri.
The price is CNY402
CNY446 total
includes taxes & fees
Jul 12 - Jul 13
Super 8 by Wyndham Charleston/Sikeston East MO

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (330 reviews)
Relax in this Union City hotel where the 24-hour fitness center keeps you energized. Free breakfast, WiFi, and parking await near Discovery Park of America. After exploring nearby attractions, return to rooms praised by guests for comfort and service.
The price is CNY744
CNY883 total
includes taxes & fees
Jul 12 - Jul 13
Holiday Inn Express & Suites Union City by IHG

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (186 reviews)
Minutes from County Market Place, this hotel offers a welcoming indoor pool, fitness center, and free breakfast. Guests rave about the helpful staff, while free parking makes exploring easy. Reelfoot Shopping Center is nearby for retail therapy.
The price is CNY721
CNY856 total
includes taxes & fees
Jun 28 - Jun 29
Hampton Inn Union City

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (789 reviews)
This peaceful hotel offers a complimentary continental breakfast, free WiFi, and convenient parking. Located near I-55 Exit 67, guests consistently praise the helpful staff and clean rooms that provide a quiet retreat after exploring local attractions.
The price is CNY524
CNY597 total
includes taxes & fees
Jun 21 - Jun 22
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (498 reviews)
The price is CNY471
CNY541 total
includes taxes & fees
Jun 21 - Jun 22
Reelfoot Lake Inn

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,000 reviews)
Travelers rave about this serene retreat with helpful staff and clean rooms. Take advantage of free WiFi, parking, and on-the-go breakfast. Work out in the fitness center before exploring Central Park and Sikeston Depot Museum nearby.
The price is CNY460
CNY524 total
includes taxes & fees
Jun 21 - Jun 22
Days Inn and Suites by Wyndham Sikeston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
The price is CNY827
CNY936 total
includes taxes & fees
Jul 5 - Jul 6
TownePlace Suites by Marriott Sikeston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
Active travelers will appreciate the health club at this comfortable Charleston motel. Free WiFi keeps you connected, while complimentary parking saves you money. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
The price is CNY483
CNY536 total
includes taxes & fees
Jul 1 - Jul 2
Eagle Inn Charleston

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (139 reviews)
This welcoming motel offers convenience with complimentary WiFi and parking, plus round-the-clock front desk assistance. Explore nearby Central Park and Sikeston Depot Museum before returning to your comfortable accommodations.
The price is CNY413
CNY491 total
includes taxes & fees
Jun 19 - Jun 20
Country Yard Inn and Suite
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in East Prairie

Learn more about East Prairie

East Prairie is well-known for its attractions such as Big Oak Tree State Park and Mississippi River.

The Mississippi River near Hannibal, Missouri, USA

Check out reviews of East Prairie hotels guests love

Frequently asked questions

How much does a hotel room cost in East Prairie?
You can choose a great hotel in East Prairie from CNY414 with properties to suit all budgets and needs. To find an affordable hotel in East Prairie that meets all of your requirements, just apply filters on Hotels.com and sort hotels by "Price: low to high".
How can I find deals and earn rewards at East Prairie hotels?
Discover great deals on East Prairie hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on East Prairie hotels.
Can I book East Prairie hotels with free cancellation?
It's easy to book a refundable East Prairie hotel on Hotels.com. Simply filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What hotels do travelers like in East Prairie?
Can I book a refundable hotel in East Prairie?
If you need the flexibility to change your travel plans to East Prairie, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in East Prairie be like during my trip?
July and August are typically the warmest months in East Prairie when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. March and April are the months with the most rain.
Why should I book my East Prairie accommodation with Hotels.com?
There are lots of reasons to book your East Prairie trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.