Hotels in Santa Clara

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Where to stay in Santa Clara?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Santa Clara on Hotels.com. These Santa Clara hotels consistently deliver on quality, location and traveler experience. Last updated on October 28, 2026.

A swimming pool with a water feature, surrounded by plants and seating areas.

1. Holiday Inn Panama Canal by IHG

Panama City

CNY821 total

includes taxes & fees

Nov 2 - Nov 3

A poolside area with lounge chairs and a covered seating area, reflecting the pool and surrounding structures.

2. Summit Rainforest Golf Resort & All Inclusive

Panama City

CNY1,611 total

includes taxes & fees

Oct 29 - Oct 30

A hotel with a swimming pool, a covered area, and a multi-story building with balconies.

3. Gamboa Rainforest Reserve

Colon

CNY1,049 total

includes taxes & fees

Nov 27 - Nov 28

A resort with a large swimming pool, thatched-roof structures, and palm trees.

4. Dreams Playa Bonita Panama - All Inclusive

Veracruz

CNY1,875 total

includes taxes & fees

Nov 3 - Nov 4

A modern, well-lit buffet area with a variety of food items and neatly arranged plates.

5. Best Western El Dorado Panama Hotel

Bethania

CNY733 total

includes taxes & fees

Nov 9 - Nov 10

A rooftop pool area with lounge chairs and a bar, overlooking a city skyline at sunset.

6. Marriott Panama Hotel

Panama City

CNY1,305 total

includes taxes & fees

Nov 21 - Nov 22

A resort with a pool area, lounge chairs, and a view of a bridge at night.

7. Radisson Hotel Panama Canal

Amador

CNY620 total

includes taxes & fees

Nov 4 - Nov 5

A pool area with a covered patio, outdoor seating, and a bar area.

8. Albrook Inn

Panama City

CNY469 total

includes taxes & fees

Oct 30 - Oct 31

A hotel with a pool, beach, and palm trees.

9. The Westin Playa Bonita Panama

Veracruz

CNY1,512 total

includes taxes & fees

Nov 10 - Nov 11

A buffet with various food items and a decorative plant.

10. Sheraton Grand Panama

San Francisco

CNY1,419 total

includes taxes & fees

Nov 6 - Nov 7

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.

11. Hotel Riu Plaza Panama

Bella Vista

CNY878 total

includes taxes & fees

Nov 22 - Nov 23

A nighttime city skyline with illuminated buildings reflected in a body of water.

12. Ramada Plaza by Wyndham Panama Punta Pacifica

San Francisco

CNY686 total

includes taxes & fees

Nov 11 - Nov 12

A modern lobby with a curved ceiling, seating area with chairs and a sofa, and artwork on the walls.

13. Hotel y Casino Central Park Panama

Bethania

CNY475 total

includes taxes & fees

Oct 29 - Oct 30

A reception area with a wooden desk, two chairs, and a plant.

14. MARINN Tropical Vibes Hotel

Amador

CNY381 total

includes taxes & fees

Nov 11 - Nov 12

A hotel entrance with a central water feature, seating areas, and potted plants.

15. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz

CNY2,291 total

includes taxes & fees

Nov 22 - Nov 23

A modern lobby with a chandelier, seating area, reception desk, and a staircase.

16. The Executive Hotel

Bella Vista

CNY585 total

includes taxes & fees

Nov 22 - Nov 23

A rooftop pool with lounge chairs and a city skyline view.

17. TRYP by Wyndham Panamá Centro

Bella Vista

CNY636 total

includes taxes & fees

Nov 11 - Nov 12

A poolside area with lounge chairs and a view of the ocean.

18. JW Marriott Panama

San Francisco

CNY2,283 total

includes taxes & fees

Nov 28 - Nov 29

A rooftop pool with a city view, modern architecture, and outdoor seating.

19. The Westin Panama

Costa del Este

CNY2,075 total

includes taxes & fees

Nov 7 - Nov 8

A buffet with various food items including fruits, juices, and cheeses.

20. Courtyard by Marriott Panama Metromall

San Antonio

CNY742 total

includes taxes & fees

Nov 20 - Nov 21

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Go beyond your typical stay in Santa Clara

Pet friendly

Apartment

Top landmarks in Santa Clara

Culebra Cut

8.0/10 (14 reviews)

If you're planning a bit of sightseeing during your trip, head to Culebra Cut— just one of the landmarks located 5.8 mi (9.3 km) from central Santa Clara.

See properties

Learn more about Santa Clara

The region around Santa Clara is home to attractions such as Culebra Cut and Albrook Shopping Mall.

See all hotels in Santa Clara

A beach with waves, a boat, and a forested hill in the background.

Check out reviews of Santa Clara hotels guests love

Hotel Dann Carlton Marinn Place Panama Financial District

10/10 Excellent

"Annika and others were incredible. All of the staff made my stay wonderful!"

Decapolis Hotel Panama City

8/10 Good

"Excelente ubicación y condiciones del hotel. El desayuno es bueno, variado y tienen una agencia de viajes que te ayuda con tours y movilizacion (muy recomendado). Lo único malo es que las puertas de los baños en las habitaciones son de vidrio y no se tiene mucha privacidad. El hotel ya tiene algunos años y se nota en algunas partes sin embargo es muy buena y recomendada opción."

Frequently asked questions

How much does a hotel room cost in Santa Clara?

You can choose a great hotel in Santa Clara from CNY267 with properties to suit all budgets and needs. If you're looking for an affordable hotel in Santa Clara that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Santa Clara hotels?

Discover great deals on Santa Clara hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If it's a spontaneous trip, check out our last-minute deals on Santa Clara hotels.

Can I book Santa Clara hotels with free cancellation?

To book a refundable Santa Clara hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some popular hotels in central Santa Clara?

If you're looking for hotels in central Santa Clara, check out Gatun Lake Lodge Hotel. Travelers love Gatun Lake Lodge Hotel for its location, as well as the outdoor pool, poolside bar and free continental breakfast this lodge offers.

Can I book a refundable accommodation in Santa Clara?

If you want the flexibility to change your plans to Santa Clara, most properties offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Clara be like during my trip?

With an average temperature of 78°F, Santa Clara is a great place if you want to enjoy the sunshine year all year long.

Why should I book my Santa Clara accommodation with Hotels.com?

There are plenty of reasons to book your Santa Clara travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.