Hotels in Clarksdale

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Where to stay in Clarksdale?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Clarksdale on Hotels.com. These Clarksdale hotels consistently deliver on quality, location and traveler experience. Last updated on September 9, 2026.

1. Stoney Creek Hotel St. Joseph

St. Joseph

CNY809

CNY936 total

includes taxes & fees

Sep 13 - Sep 14

Suite, 2 Queen Beds, Accessible (Sofa Sleeper, Roll-in Shower, 2 Rooms)

2. Drury Inn & Suites St Joseph

St. Joseph

CNY738

CNY854 total

includes taxes & fees

Sep 20 - Sep 21

3. Fairfield Inn & Suites by Marriott St. Joseph

St. Joseph

CNY703

CNY820 total

includes taxes & fees

Oct 4 - Oct 5

4. Quality Inn Cameron

Cameron

CNY771

CNY856 total

includes taxes & fees

Oct 8 - Oct 9

5. Holiday Inn Express Hotel & Suites St. Joseph by IHG

St. Joseph

CNY678

CNY784 total

includes taxes & fees

Oct 4 - Oct 5

6. Hampton Inn St. Joseph

St. Joseph

CNY600

CNY694 total

includes taxes & fees

Oct 4 - Oct 5

7. Home2 Suites By Hilton St. Joseph

St. Joseph

CNY765

CNY885 total

includes taxes & fees

Oct 4 - Oct 5

8. My Place Hotel St Joseph MO

St. Joseph

CNY607

CNY702 total

includes taxes & fees

Oct 4 - Oct 5

Deluxe Room, 1 Queen Bed, Accessible (Smoke Free)

9. Red Roof Inn Cameron

Cameron

CNY522

CNY574 total

includes taxes & fees

Oct 1 - Oct 2

10. SureStay Hotel by Best Western Cameron

Cameron

CNY525

CNY577 total

includes taxes & fees

Sep 18 - Sep 19

Standard Double Room, Ensuite (Single Queen ) | Bathroom

11. Whiskey Mansion

St. Joseph

CNY1,047

CNY1,211 total

includes taxes & fees

Sep 10 - Sep 11

12. Super 8 by Wyndham Cameron

Cameron

CNY593

CNY652 total

includes taxes & fees

Oct 10 - Oct 11

13. Vineyard Mansion & Carriage House Bed & Breakfast

St. Joseph

CNY718

CNY1,056 total

includes taxes & fees

Sep 20 - Sep 21

14. AmeriStay Inn

St. Joseph

CNY442

CNY512 total

includes taxes & fees

Sep 23 - Sep 24

Standard Room, 2 Queen Beds, Smoking, Ground Floor

15. Econo Lodge Cameron

Cameron

CNY502

CNY552 total

includes taxes & fees

Oct 4 - Oct 5

16. Motel 6 Saint Joseph, MO

St. Joseph

CNY402

CNY466 total

includes taxes & fees

Oct 4 - Oct 5

17. Motel 6 Cameron, MO

Cameron

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Go beyond your typical stay in Clarksdale

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Check out reviews of Clarksdale hotels guests love

Home2 Suites By Hilton St. Joseph

10/10 Excellent

"Location was close to restaurants and shopping."

Drury Inn & Suites St Joseph

10/10 Excellent

"Very clean friendly staff."

SureStay Hotel by Best Western Cameron

8/10 Good

"Y"

Hampton Inn St. Joseph

8/10 Good

"Clean rooms,staff was very helpful. Pet friendy."

Holiday Inn Express Hotel & Suites St. Joseph by IHG

10/10 Excellent

"Clean room with comfortable bed. Wonderful breakfast buffet."

Vineyard Mansion & Carriage House Bed & Breakfast

10/10 Excellent

"Marcena was so welcoming and took great care of me. If I come back to St. Jo, I'd.love to stay there again. Thank you!"

My Place Hotel St Joseph MO

10/10 Excellent

"Never stayed at one. It was awesome. Very clean room with tons of amenities. Staff was wonderful and the parking was great. Kitchen was very useful."

Whiskey Mansion

10/10 Excellent

"The breakfast was truly amazing. Everything prepared from scratch. The host was so friendly and helpful.If you love old mansions you’ll love Whiskey Mansion."

Motel 6 Saint Joseph, MO

8/10 Good

"Yes. Air was nice and cool! No pets with me."

Frequently asked questions

How much does a hotel room cost in Clarksdale?

You can find top hotels in Clarksdale from CNY466 with options to suit your budget and needs. If you're looking for an affordable hotel in Clarksdale that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Clarksdale hotels?

Discover great deals on Clarksdale hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. If it's a spontaneous trip, check out our last-minute deals on Clarksdale hotels.

Can I book Clarksdale hotels with free cancellation?

To book a refundable Clarksdale hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

Can I book a refundable hotel in Clarksdale?

If you're looking for the flexibility to change your plans to Clarksdale, most accommodations offer refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Clarksdale be like during my visit?

The warmest months in Clarksdale are usually July and August with an average temp of 74°F. January and February are the chilliest months when the average temp is 33°F. The rainiest months are May and July.

Why should I book my Clarksdale hotel with Hotels.com?

There are plenty of reasons to book your Clarksdale travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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