Hotels in De Soto

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Top 5 hotels in De Soto at a glance

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG — 2.5-star hotel in Murphysboro. Guest rating: 9.4/10 — Exceptional.
Walker's Bluff Casino Resort — 4.5-star hotel in Carterville. Guest rating: 9.4/10 — Exceptional.
Home2 Suites by Hilton Carbondale — 3-star hotel in Carbondale. Guest rating: 8.8/10 — Excellent.
Hampton Inn Carbondale — 2.5-star hotel in Carbondale. Guest rating: 8.4/10 — Very Good.
Comfort Inn & Suites Carbondale University Area — 2.5-star hotel in Carbondale. Guest rating: 7.6/10 — Good.

Where to stay in De Soto?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in De Soto on Hotels.com. These De Soto hotels consistently deliver on comfort, location and traveler experience. Last updated on August 26, 2026.

In-room safe, desk, iron/ironing board, WiFi (free)

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

CNY820

CNY910 total

includes taxes & fees

Aug 30 - Aug 31

Sauna, hot tub, body treatments, hot stone massages

3 restaurants; breakfast, lunch, dinner, and brunch served

Walker's Bluff Casino Resort

Carterville

CNY841

CNY933 total

includes taxes & fees

Aug 30 - Aug 31

Home2 Suites by Hilton Carbondale

Carbondale

CNY772

CNY887 total

includes taxes & fees

Sep 2 - Sep 3

Hampton Inn Carbondale

Carbondale

CNY656

CNY754 total

includes taxes & fees

Sep 2 - Sep 3

Room, 1 King Bed, Accessible, Non Smoking | Down comforters, desk, laptop workspace, blackout drapes

Comfort Inn & Suites Carbondale University Area

Carbondale

CNY572

CNY657 total

includes taxes & fees

Sep 9 - Sep 10

Studio Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, iron/ironing board, rollaway beds (surcharge)

Standard Room, 2 Queen Beds | Room amenity

Desk, laptop workspace, iron/ironing board, rollaway beds (surcharge)

Super 8 by Wyndham Carbondale

Carbondale

CNY437

CNY502 total

includes taxes & fees

Aug 30 - Aug 31

Standard Room, 2 Double Beds, Accessible, Refrigerator & Microwave (Pet Friendly) | Desk, blackout drapes, iron/ironing board, WiFi (free)

Best Western Saluki Inn

Carbondale

CNY571

CNY670 total

includes taxes & fees

Sep 9 - Sep 10

Drury Inn & Suites Marion

Marion

CNY679

CNY815 total

includes taxes & fees

Sep 27 - Sep 28

In-room safe, iron/ironing board, WiFi (free), bed sheets

Quality Inn Carbondale University area

Carbondale

CNY447

CNY514 total

includes taxes & fees

Aug 30 - Aug 31

Suite, 1 King Bed, Non Smoking | Premium bedding, in-room safe, desk, laptop workspace

Comfort Inn & Suites Marion I-57

Marion

CNY756

CNY907 total

includes taxes & fees

Sep 20 - Sep 21

Indoor pool, open 7 AM to 10 PM, sun loungers

Holiday Inn Express & Suites Carbondale - University Area by IHG

Carbondale

CNY766

CNY881 total

includes taxes & fees

Aug 30 - Aug 31

Desk, iron/ironing board, rollaway beds (surcharge), WiFi (free)

Baymont by Wyndham Marion

Marion

CNY550

CNY661 total

includes taxes & fees

Sep 20 - Sep 21

Iron/ironing board, cribs (surcharge), WiFi (free), alarm clocks

Americas Best Value Inn West Frankfort

West Frankfort

CNY504

CNY559 total

includes taxes & fees

Aug 28 - Aug 29

Fairgrounds Inn

Du Quoin

CNY575

CNY638 total

includes taxes & fees

Aug 30 - Aug 31

Desk, iron/ironing board, WiFi (free), alarm clocks

Motel 6 Marion, IL

Marion

CNY437

CNY485 total

includes taxes & fees

Aug 31 - Sep 1

Country Inn & Suites by Radisson, Marion, IL

Marion

CNY645

CNY774 total

includes taxes & fees

Sep 20 - Sep 21

Hypo-allergenic bedding available, in-room safe, desk, laptop workspace

Best Western Marion Hotel

Marion

CNY491

CNY590 total

includes taxes & fees

Sep 2 - Sep 3

Desk, iron/ironing board, cribs (free), rollaway beds (free)

Studio Suite, 1 King Bed, Non Smoking | Desk, iron/ironing board, cribs (free), rollaway beds (free)

Super 8 by Wyndham Marion

Marion

CNY448

CNY537 total

includes taxes & fees

Sep 1 - Sep 2

Romantic Cottage, 1 King Bed, Non Smoking (Indigo Cottage) | Living area

Deluxe Cottage, Multiple Beds, Non Smoking (West End Cottage) | Living area

Romantic Cottage, 1 King Bed, Non Smoking (Indigo Cottage) | Egyptian cotton sheets, premium bedding, pillowtop beds, blackout drapes

Makanda Inn

Makanda

CNY2,026

CNY2,310 total

includes taxes & fees

Aug 28 - Aug 29

Suite, 1 King Bed with Sofa bed, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board (on request)

University Inn of Carbondale by Hotel O

Carbondale

CNY341

CNY426 total

includes taxes & fees

Aug 30 - Aug 31

View all properties

Go beyond your typical stay in De Soto

Pet friendly

Pool

Family friendly

Top landmarks in De Soto

De Soto City Park

De Soto City Park is 0.6 mi (1 km) from central De Soto, why not stop by during your stay. If you like De Soto City Park, you'll love Parkview Park and Longfellow Park, both just a short drive away.

See properties

Check out reviews of De Soto hotels guests love

Walker's Bluff Casino Resort

10/10 Excellent

"I liked all of it"

Baymont by Wyndham Marion

10/10 Excellent

"Nice rooms and beds. Good shower and water pressure. Good AC!"

Home2 Suites by Hilton Carbondale

8/10 Good

"I would recommend this location for a quick stay."

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

10/10 Excellent

"Great hotel very clean great food"

Holiday Inn Express & Suites Carbondale - University Area by IHG

10/10 Excellent

"Great stay"

Country Inn & Suites by Radisson, Marion, IL

10/10 Excellent

"The check in process was amazing. I expect a little southern hospitality in this part of the state, but they went above and beyond making sure that we picked the right rooms. There was a band "hinder" playing a concert in te let next to the hotel, which was actually really cool, but she made sure to ask us if that would bother us and even knew when they would stop. The room was very clean and taken care of, even though the features are dated. It lacks a thermostat and honestly has an older HVAC system. This means that the room was the perfect temperature, but there was a bit of dampness in the air. It would help to upgrade. But it didn't bother my sleeping and the bed was comfortable enough. Every staff member said "Hello" and did what they could to help. Freah cookies in the lobby were great. The breakfast was only so, so. I think that there is room for improvement here. Fresher food would be the place that I would start. Krispy Kreme is on your doorstep, make a deal. Also, in my humble opinion taking a look at how the coffee is made would not hurt, it might be a water filter that is needed. Not sure there. Over all, I would stay here again. If I were the corporate company or ownership, I would make sure that this general manager has everything that they need to make this property better. It's a true example of doing the best you can with what you have."

Motel 6 Marion, IL

10/10 Excellent

"clean room and great staff"

Hampton Inn Carbondale

10/10 Excellent

"Desk agent at check-in was great, very friendly and effective at helping me get situated. Big THANKS!"

Holiday Inn Express Hotel & Suites Marion Northeast by IHG

10/10 Excellent

"Clean and very friendly staff. Enjoyed my 3 night stay."

Frequently asked questions

How much does a hotel room cost in De Soto?

You can discover great hotels in De Soto from CNY426 with properties to suit all budgets and needs. If you're looking for an affordable hotel in De Soto that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at De Soto hotels?

Discover great deals on De Soto hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on De Soto hotels.

Can I book De Soto hotels with free cancellation?

In order to book a refundable De Soto hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some popular hotels in central De Soto?

For hotels in central De Soto, check out Walker's Bluff Casino Resort and Holiday Inn Express & Suites Carbondale - University Area by IHG. Travelers love Walker's Bluff Casino Resort for its location, as well as the indoor pool, casino and hot tub this resort offers. Holiday Inn Express & Suites Carbondale - University Area by IHG is another popular central hotel with an indoor pool, a 24-hour gym and free parking.

What accommodations do travelers like in De Soto?

Guests like Walker's Bluff Casino Resort, Holiday Inn Express & Suites Murphysboro - Carbondale by IHG and Holiday Inn Express & Suites Carbondale - University Area by IHG.

Can I book refundable accommodations in De Soto?

If you need the flexibility to change your plans to De Soto, most accommodations offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in De Soto be like during my vacation?

The warmest months in De Soto are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 39°F. The rainiest months are April and March.

Why should I book my De Soto hotel through Hotels.com?

There are plenty of reasons to book your De Soto travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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