Hotels in Old Appleton

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top 5 hotels in Old Appleton at a glance

1. Drury Inn & Suites Jackson MO — 3-star hotel in Jackson. Guest rating: 9.6/10 — Exceptional.
2. Holiday Inn Express & Suites Perryville by IHG — 2.5-star hotel in Perryville. Guest rating: 9.2/10 — Wonderful.
3. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau — 3-star hotel in Jackson. Guest rating: 9.0/10 — Wonderful.
4. Perryville RV Resort — 2-star hotel in Perryville. Guest rating: 9.6/10 — Exceptional.
5. Tru By Hilton Cape Girardeau — 2.5-star hotel in Cape Girardeau. Guest rating: 9.6/10 — Exceptional.

Where to stay in Old Appleton?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Old Appleton on Hotels.com. These Old Appleton hotels consistently deliver on comfort, location and traveler experience. Last updated on August 14, 2026.

Desk, laptop workspace, blackout drapes, iron/ironing board

1. Drury Inn & Suites Jackson MO

Jackson

CNY540

CNY570 total

includes taxes & fees

Aug 23 - Aug 24

In-room safe, desk, blackout drapes, soundproofing

2. Holiday Inn Express & Suites Perryville by IHG

Perryville

CNY614

CNY703 total

includes taxes & fees

Sep 13 - Sep 14

Hypo-allergenic bedding available, desk, laptop workspace

3. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

CNY625

CNY676 total

includes taxes & fees

Aug 26 - Aug 27

4. Perryville RV Resort

Perryville

CNY448

CNY513 total

includes taxes & fees

Sep 14 - Sep 15

Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing)

5. Tru By Hilton Cape Girardeau

Cape Girardeau

CNY603

CNY686 total

includes taxes & fees

Aug 23 - Aug 24

6. Comfort Suites Jackson-Cape Girardeau

Jackson

CNY570

CNY617 total

includes taxes & fees

Aug 16 - Aug 17

Suite, 1 King Bed, Non Smoking (1 Bedroom) | In-room safe, desk, laptop workspace, blackout drapes

Studio Suite, 1 King Bed, Accessible, Non Smoking (Mobility Accessible) | In-room safe, desk, laptop workspace, blackout drapes

7. Super 8 by Wyndham Perryville

Perryville

CNY459

CNY525 total

includes taxes & fees

Sep 13 - Sep 14

8. Days Inn by Wyndham Perryville

Perryville

CNY455

CNY521 total

includes taxes & fees

Sep 14 - Sep 15

Suite 11, 1 Queen Bed with Sofa bed, Pets Allowed | Interior

9. The Atrium - A Boutique Hotel

Perryville

CNY510

CNY1,076 total

includes taxes & fees

Sep 14 - Sep 15

Coffee/tea maker, full-size fridge, microwave, oven

Urban Loft 1 | Egyptian cotton sheets, premium bedding, down comforters

Egyptian cotton sheets, premium bedding, down comforters

10. Urban Lofts

Perryville

CNY1,360

CNY2,098 total

includes taxes & fees

Sep 14 - Sep 15

11. Quality Inn Cape Girardeau North

Cape Girardeau

CNY416

CNY470 total

includes taxes & fees

Sep 13 - Sep 14

12. The Mediterranean House 1858

Perryville

CNY3,394

CNY5,508 total

includes taxes & fees

Sep 14 - Sep 15

Iron/ironing board, rollaway beds (free), WiFi (free), bed sheets

13. Quality Inn Perryville I-55

Perryville

CNY455

CNY521 total

includes taxes & fees

Sep 1 - Sep 2

View all properties

Go beyond your typical stay in Old Appleton

Pet friendly

Pool

Check out reviews of Old Appleton hotels guests love

Drury Inn & Suites Jackson MO

10/10 Excellent

"The kick-back after a day of travel is a most welcome amenity, and the breakfast is always great. Drury is our favorite place to stay."

Tru By Hilton Cape Girardeau

10/10 Excellent

"Clean"

Perryville RV Resort

10/10 Excellent

"Great time"

Super 8 by Wyndham Perryville

10/10 Excellent

"Super 8 is my go to when I need to get a room."

The Atrium - A Boutique Hotel

10/10 Excellent

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Frequently asked questions

How much does a hotel room cost in Old Appleton?

You can find top hotels in Old Appleton from CNY470 with options to suit your budget and needs. If you're after an affordable hotel in Old Appleton that meets all of your requirements, set your filters and then sort the results by "Price: low to high".

How can I find deals and earn rewards at Old Appleton hotels?

Discover great deals on Old Appleton hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. If it's a spontaneous trip, check out our last-minute deals on Old Appleton hotels.

Can I book Old Appleton hotels with free cancellation?

To book a refundable Old Appleton hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

Can I book a refundable hotel in Old Appleton?

If you're looking for the flexibility to change your travel plans to Old Appleton, most hotels offer refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Old Appleton be like during my visit?

The warmest months in Old Appleton are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 40°F. The rainiest months are April and March.

Why should I book my Old Appleton hotel through Hotels.com?

There are plenty of reasons to book your Old Appleton travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Keep exploring

Book Hotels in Old Appleton on Hotels.com