Hotels in Cherokee

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Where to stay in Cherokee?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Cherokee on Hotels.com. These Cherokee hotels consistently deliver on quality, location and traveler experience. Last updated on October 12, 2026.

A spacious interior with a central staircase, a chandelier, and a view to the outdoors.

A hotel room with a bed, sofa, armchair, small table, and a desk.

A spacious conference room with a high ceiling, large windows, and a grey carpet.

A modern dining area with wooden tables and benches, green chairs, and pendant lighting.

1. Spark by Hilton Tuscumbia Muscle Shoals

Tuscumbia

CNY563

CNY625 total

includes taxes & fees

Oct 18 - Oct 19

A reception area with a wooden counter, a seating area with a chair and a sofa, and a trash bin.

A hotel entrance with a prominent 'HOTEL' sign, a covered entrance area, and a stone facade.

A bathroom with a wooden vanity, a white sink, a mirror, and a towel rack.

A hotel room with two beds, a TV, and a sliding door to the outside.

2. Heritage PLACE HOTEL IUKA

Iuka

CNY527

CNY575 total

includes taxes & fees

Oct 13 - Oct 14

A spacious lobby with a blue sofa, a wooden table, and chairs. There is a TV on a stand and a painting on the wall.

A reception area with a 'Welcome to the Honey Bee State' sign, a Hilton Honors sign, and a 'Team Members' sign.

A hotel room with a bed, a desk, a television, a sofa, and a window with curtains.

A snack bar with refrigerated drinks, shelves stocked with snacks, and a wall sign advertising treats.

3. Hampton Inn & Suites Florence-Downtown

Florence

CNY1,024

CNY1,178 total

includes taxes & fees

Oct 29 - Oct 30

A hotel room with a bed, a desk, a chair, a mirror, a painting, and a nightstand with a lamp.

A kitchen with blue tiles, a coffee machine, and a sink.

A Days Inn hotel with a large entrance canopy, multiple balconies, and a parking lot.

A reception area with a reception desk, a blue sofa, and a coffee station.

4. Days Inn by Wyndham Muscle Shoals Florence

Muscle Shoals

CNY477

CNY529 total

includes taxes & fees

Oct 13 - Oct 14

A restaurant interior with a bar area, seating, and a counter with a coffee machine.

The Stricklin Hotel with a sign for Big Bad Breakfast.

A bedroom with a brick wall, a dark blue headboard, and patterned pillows.

A modern kitchen with dark blue cabinets, a white countertop, and a wooden floor.

5. The Stricklin Hotel

Florence

CNY1,025

CNY1,183 total

includes taxes & fees

Oct 13 - Oct 14

A hotel lobby with a seating area, a reception desk, and a check-in counter.

A fire pit surrounded by stone, with outdoor furniture and a pool in the background.

A hotel room with a bed, a TV, a desk with a chair, a coffee maker, and a map on the wall.

A modern hotel lobby with a bar area, seating arrangements, and a fireplace.

6. Residence Inn Florence Marriott

East Florence

CNY870

CNY1,001 total

includes taxes & fees

Nov 1 - Nov 2

A modern bathroom with a freestanding bathtub, a blue chair, and a wooden bench.

A spacious dining area with multiple tables and chairs, an air conditioning unit, and a large window providing a view of the outdoors.

A hotel entrance with a covered walkway, a reception desk, and a parking lot.

A hotel room with a bed, a desk with a lamp, a TV, a sofa, and a view of greenery outside.

7. Comfort Inn & Suites Tuscumbia - Muscle Shoals

Tuscumbia

CNY702

CNY780 total

includes taxes & fees

Oct 19 - Oct 20

A hotel room with a bed, a desk with chairs, a small kitchenette, and a TV.

A hotel reception area with a green sofa, a wooden reception desk, and a television on a cabinet.

A swimming pool with a white fence, lounge chairs, and a sign for the Microtel Inn & Suites by Wyndham.

A Microtel Inn & Suites building with a parking lot and a sign indicating the hotel name.

8. Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

Tuscumbia

CNY421

CNY467 total

includes taxes & fees

Nov 1 - Nov 2

A modern kitchen with wooden cabinets, a countertop with various appliances, and a view of the outdoors.

A reception area with two wooden reception desks, a blue rug, and a modern interior design.

An indoor swimming pool with clear water, tiled walls, and a lifeguard chair.

A hotel room with two beds, a wooden headboard, a wall-mounted light fixture, and a framed picture.

9. Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG

Florence

CNY790

CNY908 total

includes taxes & fees

Nov 1 - Nov 2

A hotel with a large pool area, a water tower, and a dome structure.

A modern bathroom with a large mirror, two sinks, a bathtub, a shower, and a fireplace.

A restaurant with a curved layout, large windows offering a view of a body of water, and a bar area with a view.

A spacious living area with large windows, a central coffee table, sofas, and armchairs.

10. Renaissance Shoals Resort & Spa

East Florence

CNY1,934

CNY2,224 total

includes taxes & fees

Oct 14 - Oct 15

A spacious lobby with seating areas, a reception desk, and large windows.

A spacious lobby with a reception desk, seating area, and large windows.

A gym with treadmills, elliptical machines, and free weights.

A spacious indoor area with large windows, seating arrangements, and a flat-screen TV mounted on the wall.

11. Clarion Inn Sheffield Muscle Shoals

Sheffield

CNY540

CNY607 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lounge with a fireplace, leather sofas, and a bar area.

A teal armchair with wooden legs, a small round table with a white vase, and a hanging lamp.

A coffee shop with a large sign reading "COFFEE" and a smaller sign below stating "HOT SHAVES! CLEAN HANDS! ALWAYS FRESH!".

A spacious bedroom with a large bed, a chandelier, and a stone wall.

12. GunRunner Boutique Hotel

Florence

CNY1,378

CNY1,591 total

includes taxes & fees

Oct 18 - Oct 19

A snack bar with shelves of snacks and a refrigerator with beverages.

A modern hotel room with a large bed, a desk, a chair, a window with a view, and a wall-mounted lamp.

A gym with cardio machines, weight benches, and a wall-mounted medicine ball rack.

A modern room with a wooden floor, a white desk with a coffee machine, a small fridge, and a window with a view of the outside.

13. Hampton Inn Florence Midtown near University of North Alabama

Florence

CNY873

CNY1,003 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with a reception desk, seating area, and a balcony.

A hotel room with a teal accent wall, a sofa, a wooden coffee table, a bed with white linens, and two bedside lamps.

A hotel room with a bed, a sofa, a coffee table, and two lamps.

A hotel dining area with long communal tables and chairs, a coffee station, and a kitchen in the background.

14. Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites

Tuscumbia

CNY751

CNY823 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a large bed, a TV mounted on the wall, a desk with a chair, a mirror, and a painting on the wall.

A modern kitchen with dark wooden cabinets, a round table, and red chairs.

A building with a modern architectural design, featuring arched doorways and a flat roof.

A kitchenette with a coffee maker, toaster, microwave, and various containers.

15. Red Roof Inn Muscle Shoals

Muscle Shoals

CNY535

CNY594 total

includes taxes & fees

Oct 13 - Oct 14

A modern living room with a wooden wall, a round table with stools, a sofa, a TV, and wall-mounted deer antlers.

A hotel with multiple rooms, a covered parking area, and a gravel ground.

A room with two beds, wooden walls, a window, a nightstand, and framed pictures.

A covered outdoor seating area with chairs and tables, a gravel floor, and a building with a metal exterior.

16. Pickwick Lake Lodge

Counce

CNY964

CNY1,106 total

includes taxes & fees

Oct 13 - Oct 14

An indoor swimming pool with tiled steps and a sunlit room with chairs and a window.

A spacious lobby with large windows, comfortable seating, and a patterned carpet.

A hotel lobby with a reception desk, seating area with sofas and armchairs, and a patterned carpet.

A hotel room with a blue sofa, a bed with a red blanket, a desk with a lamp, and two framed pictures on the wall.

17. Comfort Suites Florence Shoals Area

Florence

CNY603

CNY694 total

includes taxes & fees

Nov 1 - Nov 2

A blue mat with the text "Baymont Inn & Suites" on a wooden floor.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

A row of white motel buildings with blue doors, a Baymont sign, and a parking lot.

A dining area with a long table and chairs, a kitchen area with appliances, and a sign on the wall.

18. Baymont by Wyndham Florence/Muscle Shoals

Florence

CNY509

CNY585 total

includes taxes & fees

Oct 13 - Oct 14

A reception area with a counter, a television, and a door labeled "EMPLOYEES ONLY".

A building with a 'OPEN' sign, a door, windows, and a stone facade.

A hotel room with two beds, a television mounted on the wall, and a window with blinds.

A modern bathroom with a marble wall, a bathtub, and a shower area.

19. Budget Inn & Suites

East Florence

CNY397

CNY440 total

includes taxes & fees

Oct 14 - Oct 15

A reception area with a reception desk, a seating area with chairs and a table, a plant, a lamp, a bulletin board, and a window with a view of the outside.

A kitchen with white cabinets, a black countertop, and a window with striped valance.

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

A courtyard with a central stone table and four benches, surrounded by a two-story building with balconies and large windows.

20. Keywest Inn - Tuscumbia/Muscle Shoals

Tuscumbia

CNY502

CNY557 total

includes taxes & fees

Oct 13 - Oct 14

View all properties

Go beyond your typical stay in Cherokee

Pet friendly

Pool

Family friendly

Cottage

Check out reviews of Cherokee hotels guests love

Heritage PLACE HOTEL IUKA

10/10 Excellent

"Wonderful hotel"

Comfort Suites Florence Shoals Area

10/10 Excellent

"Very clean close to amenities. Very nice staff!"

Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

10/10 Excellent

"Good room, breakfast was not good, but overall a nice stay"

Baymont by Wyndham Florence/Muscle Shoals

8/10 Good

"The staff is very friendly."

Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG

10/10 Excellent

"Clean room"

Residence Inn Florence Marriott

10/10 Excellent

"People were friendly and welcoming got me right in after a inconvenience with another hotel and bugs very thankful for that"

Clarion Inn Sheffield Muscle Shoals

10/10 Excellent

"The place was perfect. Nothing fancy. Clean rooms, friendly staff, comfortable beds, good water pressure. OK, so the couch in our room was terribly uncomfortable, but we'll definitely stay here again next year for ShoalsFest."

Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites

10/10 Excellent

"I had a very nice stay here. Clean, accessible, helpful staff, nice cold A/C, easy to park. Near a McDonald's and a convenience store and gas station. I would stay again, thanks!"

The Stricklin Hotel

10/10 Excellent

"Room was super clean, comfortable and exactly as pictured. Staff was friendly and helpful. Great location to all downtown Florence activities and restaurants."

Frequently asked questions

How much does a hotel room cost in Cherokee?

You can find top hotels in Cherokee from CNY440 with options to suit your budget and needs. If you're after an affordable hotel in Cherokee that meets all of your requirements, set your filters and then sort the results by "Price: low to high".

How can I find deals and earn rewards at Cherokee hotels?

Discover great deals on Cherokee hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. If it's a spontaneous trip, check out our last-minute deals on Cherokee hotels.

Can I book Cherokee hotels with free cancellation?

To book a refundable Cherokee hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

Can I book refundable hotels in Cherokee?

If you want the flexibility to change your plans to Cherokee, most accommodations provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Cherokee if I want a vacation home instead of a hotel?

You'll find 6 vacation homes on our site.

What will the weather in Cherokee be like during my trip?

The warmest months in Cherokee are usually July and August with an average temp of 77°F. January and February are the chilliest months when the average temp is 45°F. The rainiest months are April and March.

Why should I book my Cherokee hotel through Hotels.com?

There are plenty of reasons to book your Cherokee travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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