Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Great weekend hotel deals in South San Francisco, CA
Showing deals for:Aug 22 - Aug 24
Image gallery for La Quinta Inn & Suites by Wyndham San Francisco Airport N
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Downtown South San Francisco buzzes with a blend of biotech innovation and cultural diversity. Corporate towers and colorful murals tell the story of this unique business hub. You'll find authentic taquerias, dim sum houses, and Filipino eateries nestled between modern office campuses along Grand Avenue. The neighborhood comes alive during weekdays when professionals fill its plazas and restaurants.
Getting around is a breeze with nearby BART and Caltrain stations connecting you to San Francisco proper and beyond. Business hotels cater mostly to corporate travelers with practical amenities. The area quiets down after work hours, offering a genuine glimpse into Bay Area life away from tourist crowds.
Oyster Point balances sleek biotech campuses with stunning San Francisco Bay views. The waterfront promenade offers perfect spots for watching waves crash against the shore or catching a beautiful sunset. Modern plazas feature public art installations while walking paths showcase both cutting-edge architecture and natural bay ecosystems.
Business travelers appreciate the corporate hotels with meeting facilities and convenient access to office buildings. Dining options cater primarily to weekday lunch crowds, with most establishments closing early evening. The area is best explored by car, though waterfront paths provide scenic strolling opportunities away from the corporate hustle.
The East Side delivers authentic local life away from San Francisco's tourist traps. Catch Bay views from San Bruno Point Park or explore diverse family-owned restaurants along Grand Avenue serving up killer tacos and pho. This residential neighborhood mixes Hispanic and Asian influences that shine through local markets and casual eateries.
Budget travelers appreciate the affordable motels and extended-stay options that cost way less than downtown San Francisco. Buses connect to BART and Caltrain, though having wheels helps. Most spots close early, so plan your food adventures accordingly.
Paradise Valley offers a peaceful retreat from San Francisco's bustle while keeping you close to the action. This quiet residential neighborhood in South San Francisco balances suburban calm with convenient access to nearby attractions. Take a stroll through San Bruno Point Park or venture to local spots like K1 Speed for some indoor racing fun.
Budget-friendly accommodations make Paradise Valley an appealing base for Bay Area exploration. The neighborhood's proximity to San Francisco International Airport and major highways ensures easy connections throughout the region. With ample street parking and minimal crowds, you'll appreciate this low-key alternative to the city's more hectic districts.
Serra Highlands offers a peaceful retreat from the Bay Area buzz with its hillside streets and family-friendly vibe. While there aren't tourist attractions within the neighborhood itself, you'll enjoy stunning panoramic views, quiet walking paths, and easy access to nearby highlights like Serramonte Center. Morning fog rolling over the hills creates a mystical atmosphere worth waking up for.
Getting around requires a car or rideshare, as public transit is limited in this residential area. Accommodations consist mainly of vacation rental homes with suburban comforts like driveways and yards. For dining and shopping, you'll need to venture to surrounding commercial areas, making Serra Highlands perfect for travelers seeking authentic local living.
South San Francisco Convention Center is worth a visit, located 0.5 mi (0.8 km) from central South San Francisco. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
If you'd like to get a taste of South San Francisco student life, check out San Francisco Baking Institute in The East Side. Let yourself be amazed at the art galleries in the area— your cultural tour starts here. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. South San Francisco has many other landmarks you might want to see such as Golden Gate Bridge and Alcatraz Island.
See's Candies is 1.2 mi (2 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at See's Candies, you'll love K1 Speed San Francisco and Coastside Comics, both located nearby.
Enjoy the beautiful sunsets and explore San Bruno Point Park, a lovely green space in South San Francisco. Amble around this vibrant area's seaside or experience its acclaimed art scene.
Enjoy an outing to K1 Speed San Francisco during your stay in South San Francisco. Amble around this vibrant area's beautiful beaches and enjoy its top-notch restaurants.
After visiting Centennial Dog Park, make a plan to see the other sights and activities in South San Francisco. Check out the shops and top-notch restaurants in this family-friendly area.
Explore the iconic 'South San Francisco The Industrial City' sign atop Sign Hill Park. Sample diverse cuisines along Grand Avenue or catch breathtaking Bay views from nearby San Bruno Mountain.
"I was visiting SF for a 2nd time and booked the same hotel, Hotel Caza, for numerous reasons from my last visit; great location, friendly service, comfortable & clean rooms. and great facilities (including things like milk and cookies you can pickup every evening beside reception)
Again, the staff were always friendly, greeting me whenever I went out or came back in past reception. I asked for and was promptly delivered a mini fridge, whilst a small suppliment fot the week, pretty much a necessity based on the large portion sizes everywhere you eat.
Ii used the pool facilities once during my stay, towels provided beside the pool and the loungers were all comfortable. My only "gripe" (and it's really nit picking) is the pool area can be quite windy at times.
All in all I great stay and if/when I come back to SF I'll be sure to look to stay again at the hotel Caza.
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"Checkin in was super easy and the staff was informantive and accommodating. We will definitely be staying again in the future. The location is centrla to attractions and easy to catch transportation to anywhere. We had a great stay. Thank you "
Can I book refundable accommodations in South San Francisco?
If you need the flexibility to change your travel plans to South San Francisco, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in South San Francisco if I want a vacation rental instead of a hotel?
If you're looking for a good alternative to a hotel, review our selection of 57 vacation homes. In addition, you can choose from 10 apartments.
What will the weather in South San Francisco be like during my visit?
The warmest months in South San Francisco are usually September and August with an average temp of 62°F. February and January are the chilliest months when the average temp is 53°F. The rainiest months are December and January.
Why should I book my South San Francisco accommodation with Hotels.com?
There are lots of reasons to book your South San Francisco trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.
Find out more about South San Francisco
Find out more about South San Francisco
South San Francisco is a family-friendly place known for its restaurants. Simply book a local tour to enjoy your stay a little more. Top places to visit include San Francisco Bay. Popular sights in the surrounding area include Chase Center and Oracle Park.
