We stayed at this gorgeous hotel last year for just a night and loved it so much, we made a plan to specifically come back this year!
The location is perfect - steps away from the vaporetto stop to Venice (~an hour to get to San Marco), at the top of the main pedestrian street, with gorgeous views of the lagoon, and plenty of dining options nearby, including right downstairs at the hotel.
Make sure to splurge for the hotel breakfast, as the dining rooms and the view from there are simply breathtaking (actual food selection is really good, too, with everything from cornetti and fruit to savory items).
And, well, if you can, get a room with a lagoon view. It makes for a wonderfully enchanting and relaxing stay. All the rooms are very elegant and modern, and the staff is delightful. We will definitely be back!!!
P.S. If you want to do some very affordable - but surprisingly good! - shopping, keep in mind the weekly street market is on Thursday mornings and starts right outside the hotel.