The Orania is probably the best city hotel we’ve ever stayed at. We had a beautiful room with huge windows with a view of Oranienplatz, and it was squeaky clean and remarkably quiet. AC worked well. Gorgeous bathroom/shower. The staff were friendly and helpful. And the breakfast (to-order plus buffet) was delicious. A beautiful luxurious retreat during our visit to Berlin.
Multiple nice cafés and bars nearby. If you don’t know Berlin well, be advised that while the immediate hotel surroundings are lovely, the street intersection of the closest U-Bahn stop, Kotbusser Tor, is gritty and chaotic and you should be prepared for urine smell. We liked to walk to Moritzplatz to catch the U-Bahn instead when it worked out.