Hotels in Upstate South Carolina

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Jun 19 - Jun 20
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Jun 20 - Jun 21
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Jun 20 - Jun 22
Next weekend
Jun 27 - Jun 29

Where to stay in Upstate South Carolina?

Best Western Plus Greenville I-385 Inn & Suites
Free daily continental breakfast

Best Western Plus Greenville I-385 Inn & Suites

2.5 star property
9.2 out of 10, Wonderful, (1326)
The price is CNY608
CNY669 total
includes taxes & fees
Jun 29 - Jun 30
Best Western Plus Greenville I-385 Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Upstate South Carolina, SC

Showing deals for:Jun 27 - Jun 29

Image gallery for The Westin Poinsett Greenville

Meeting facility

The Westin Poinsett Greenville

4.0 star property
Greenville
9.2/10Wonderful (1,000 reviews)
15% off
Price is CNY1,399
CNY3,079 total
includes taxes & fees
The Westin Poinsett Greenville

Top neighborhoods in Upstate South Carolina

Greenville featuring autumn leaves, a garden and a bridge

Greenville Downtown

Greenville's artistic Greenville Downtown neighborhood is loved for its concert halls and riverfront, and visitors often enjoy its varied attractions including The Peace Center and Bon Secours Wellness Arena.

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Greenville Downtown

Top landmarks in Upstate South Carolina

Clemson University

Clemson University

If you'd like to get a taste of Clemson student life, check out Clemson University, located 0.5 mi (0.9 km) from central Clemson.

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Clemson University

Learn more about Upstate South Carolina

Upstate South Carolina is well-known for its university life and sports, featuring attractions such as Discovery Island Water Park and Frankie's Fun Park. This family-friendly city has something for everyone including its live music, restaurants, and sights like The Shops at Greenridge and Conestee Nature Preserve.

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Greenville - Spartanburg showing a sunset, tranquil scenes and mountains
Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism

Frequently asked questions

Can I book refundable accommodations in Upstate South Carolina?
If you're looking for the flexibility to change your plans to Upstate South Carolina, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Upstate South Carolina if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, browse our selection of 1070 vacation homes. In addition, there are 113 apartments and 89 condos.
Why should I book my Upstate South Carolina hotel through Hotels.com?
There are lots of reasons to book your Upstate South Carolina trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.