Hotels in Santiago Island

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Santiago Island?

Learn more about Santiago Island

Santiago Island is well-known for its attractions such as Galápagos National Park and Mosquera Island.

Bartolome Island featuring boating, general coastal views and rocky coastline

Check out reviews of Santiago Island hotels guests love

Frequently asked questions

Why should I book my Santiago Island hotel through Hotels.com?
There are plenty of reasons to book your Santiago Island travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.