Photo by Andrew Fry

Hotels near Mississippi River

Q: What are the best hotels near Mississippi River?

Guests love staying at The Eagles Nest Inn , which is an inn near Mississippi River. The Atrium Hotel on Third is also well reviewed by travelers and is just steps away. You'll find 175 hotels, vacation rentals, and more lodging options to choose from in the surrounding area.

Q: What are the best luxury hotels near Mississippi River?

Treat yourself when you stay at Econo Lodge Quincy , which is a short 7-minute drive from Mississippi River and offers parking.

Where to?

Dates

April 2026

15

May 2026

I'm traveling for business

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Where to stay near Mississippi River?

55-inch TV with cable channels, Netflix, Hulu

Riverside Inn Hannibal

25.1 km from Mississippi River

CNY1,342 total

includes taxes & fees

Apr 27 - Apr 28

Desk, blackout drapes, iron/ironing board, free WiFi

Town & Country Inn and Suites

45.2 km from Mississippi River

CNY1,112 total

includes taxes & fees

May 16 - May 17

Stoney Creek Inn Quincy

46.5 km from Mississippi River

CNY1,008 total

includes taxes & fees

May 3 - May 4

Drury Plaza Hotel St. Louis St. Charles

104 km from Mississippi River

CNY1,045 total

includes taxes & fees

May 3 - May 4

Quality Inn & Suites Hannibal West

30 km from Mississippi River

CNY650 total

includes taxes & fees

Apr 26 - Apr 27

Courtyard by Marriott St. Louis St. Peters

97.2 km from Mississippi River

CNY943 total

includes taxes & fees

Apr 26 - Apr 27

Premium bedding, desk, iron/ironing board, free WiFi

Sleep Inn & Suites O'Fallon MO - Technology Drive

100.2 km from Mississippi River

CNY626 total

includes taxes & fees

Apr 16 - Apr 17

WoodSpring Suites St Peters-OFallon

93.4 km from Mississippi River

CNY718 total

includes taxes & fees

Apr 25 - Apr 26

Motel 6 Hannibal, MO

26.1 km from Mississippi River

CNY440 total

includes taxes & fees

Apr 17 - Apr 18

Embassy Suites by Hilton St. Louis St. Charles

103.2 km from Mississippi River

CNY1,152 total

includes taxes & fees

May 3 - May 4

SpringHill Suites by Marriott St. Louis Airport/Earth City

107.3 km from Mississippi River

CNY971 total

includes taxes & fees

Apr 26 - Apr 27

Holiday Inn Express St. Louis West - O'Fallon by IHG

100.1 km from Mississippi River

CNY983 total

includes taxes & fees

Apr 27 - Apr 28

Staybridge Suites O'Fallon Chesterfield by IHG

100.2 km from Mississippi River

CNY975 total

includes taxes & fees

May 10 - May 11

Super 8 by Wyndham Hannibal

26.3 km from Mississippi River

CNY496 total

includes taxes & fees

Apr 26 - Apr 27

Johnstone Mansion

96.2 km from Mississippi River

CNY1,546 total

includes taxes & fees

Apr 27 - Apr 28

Residence Inn by Marriott O'Fallon

100.3 km from Mississippi River

CNY1,055 total

includes taxes & fees

May 3 - May 4

Ameristar Casino Resort and Spa

104.1 km from Mississippi River

CNY1,384 total

includes taxes & fees

Apr 28 - Apr 29

Breakfast and dinner served, American cuisine

Courtyard St. Louis Airport/Earth City

107.3 km from Mississippi River

CNY892 total

includes taxes & fees

Apr 19 - Apr 20

Comfort Inn St. Louis Airport

110.8 km from Mississippi River

CNY728 total

includes taxes & fees

Apr 19 - Apr 20

Hampton Inn St. Charles St. Peters

98.5 km from Mississippi River

CNY893 total

includes taxes & fees

Apr 26 - Apr 27

View all properties

Compare popular hotels close to Mississippi River

Property	Property class	Guest rating
Riverside Inn Hannibal	2.5 star property	9.4 Exceptional 171 reviews	View
Town & Country Inn and Suites	2.5 star property	9.2 Wonderful 912 reviews	View
Stoney Creek Inn Quincy	2.0 star property	8.8 Excellent 1,001 reviews	View
Drury Plaza Hotel St. Louis St. Charles	3.0 star property	9.6 Exceptional 1,000 reviews	View
Quality Inn & Suites Hannibal West	2.5 star property	8.0 Very Good 1,014 reviews	View

Other landmarks near Mississippi River

Mark Twain Cave

4.4/5 (89 reviews)

If you're planning a bit of sightseeing during your trip, head to Mark Twain Cave— just one of the landmarks located 3.3 mi (5.4 km) from central Hannibal.

See properties

Sawyer's Creek Fun Park

3.9/5 (16 reviews)

Sawyer's Creek Fun Park is 3.3 mi (5.3 km) from central Hannibal, why not stop by during your stay. Our travelers also like this walkable area for its restaurants. Want to stretch your legs some more? Head to Sodalis Nature Preserve, located nearby.

See properties

Frequently asked questions

What are the best hotels near Mississippi River?

Guests love staying at The Eagles Nest Inn, which is an inn near Mississippi River.
The Atrium Hotel on Third is also well reviewed by travelers and is just steps away.
You'll find 175 hotels, vacation rentals, and more lodging options to choose from in the surrounding area.

How much does it cost to stay in a hotel near Mississippi River?

You can review prices on Hotels.com by entering your search criteria and sorting by price. Remember that rates vary based on where and when you plan to go.

Search for the lowest price per night from CNY440

Can I find hotels close to Mississippi River that are fully refundable?

Yes, many hotels offer refundable room reservations if you cancel prior to the cancellation deadline. To find refundable rates, select the "Fully refundable" filter when searching for hotels.

Both The Atrium Hotel on Third and Holiday Inn Quincy East by IHG are highly rated hotels close to Mississippi River that offer these rates.

What are the best romantic hotels near Mississippi River?

For travelers looking for a romantic stay, Garth Woodside Mansion B&B offers private picnics. It's a short 9-minute drive from Mississippi River.

What are the best hotels close to Mississippi River with free breakfast?

You can begin your day with a free on-the-go breakfast at The Atrium Hotel on Third, which is steps from Mississippi River.
William Watson Hotel is also a recommended place to stay with a free on-the-go breakfast, and it's located 23 minutes away by car.

Which hotels near Mississippi River have rooms with great views?

Enjoy rooms with lake or valley views at Garth Woodside Mansion B&B, which is a short 9-minute drive from Mississippi River.
Another great choice nearby is William Watson Hotel, which has rooms with city views.

What are the best luxury hotels near Mississippi River?

Treat yourself when you stay at Econo Lodge Quincy, which is a short 7-minute drive from Mississippi River and offers parking.

What are the best hotels near Mississippi River with free parking?

Travelers looking to drive and park with ease should consider a stay at The Eagles Nest Inn, which offers free parking. You'll be steps from Mississippi River.
The Atrium Hotel on Third also has free parking and is just steps away.

What are the best hotels near Mississippi River with a pool?

Travelers can enjoy the indoor pool at Holiday Inn Quincy East by IHG. Mississippi River is a short 9-minute drive from the hotel.

What cheap motels can I book close to Mississippi River?

To save on your stay near Mississippi River, take a look at River's Edge Motel, which offers parking and hydromassage showerheads.

What are the best lodges close to Mississippi River?

Appreciate the natural setting when you stay at country lodging, which is a short 19-minute drive from Mississippi River.
Charming 4-bedroom Sleeps 10 lodge with AC and WiFi in welcoming Nebo is another lodge located 27 minutes away by car.

What are the best cabins close to Mississippi River?

West Central Lodging: Enjoy peace and quiet and parking when you stay at this cabin, which is a 29-minute drive from Mississippi River.
Lakeside Lodge of LEGENDS; A Wilderness Wanderer's Wonderland: 33 minutes away by car, here's a second cabin to consider.

What are the best pet-friendly hotels close to Mississippi River?

Bring your four-legged friend to Sleep Inn & Suites Hannibal West, which is a short 4-minute drive from Mississippi River.
Baymont by Wyndham Hannibal is a second pet-friendly option.

Hotels near Mississippi River

Room 1

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay near Mississippi River?

Riverside Inn Hannibal

Town & Country Inn and Suites

Stoney Creek Inn Quincy

Drury Plaza Hotel St. Louis St. Charles

Quality Inn & Suites Hannibal West

Courtyard by Marriott St. Louis St. Peters

Sleep Inn & Suites O'Fallon MO - Technology Drive

WoodSpring Suites St Peters-OFallon

Motel 6 Hannibal, MO

Embassy Suites by Hilton St. Louis St. Charles

SpringHill Suites by Marriott St. Louis Airport/Earth City

Holiday Inn Express St. Louis West - O'Fallon by IHG

Staybridge Suites O'Fallon Chesterfield by IHG

Super 8 by Wyndham Hannibal

Johnstone Mansion

Residence Inn by Marriott O'Fallon

Ameristar Casino Resort and Spa

Courtyard St. Louis Airport/Earth City

Comfort Inn St. Louis Airport

Hampton Inn St. Charles St. Peters

Compare popular hotels close to Mississippi River

Other landmarks near Mississippi River

Mark Twain Cave

Sawyer's Creek Fun Park

Lovers Leap

Sodalis Nature Preserve

Bluff City Theater

Planters Barn Theater

Big River Train Town

Mark Twain Boyhood Home and Museum

Frequently asked questions