Hotels in De Soto

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Where to stay in De Soto?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about De Soto

The region around De Soto is home to attractions such as Mississippi River and Big Lake.

Frequently asked questions

What hotels do travelers like in De Soto?
Guests like Scenic Valley Motel.
Can I book refundable accommodations in De Soto?
If you need the flexibility to change your travel plans to De Soto, most hotels offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in De Soto if I want a vacation home instead of a hotel?
You'll find 7 vacation homes on our site. You can also book one of the 17 cabins for your stay.
What will the weather in De Soto be like during my visit?
The warmest months in De Soto are usually July and August with an average temp of 68°F. January and February are the chilliest months when the average temp is 24°F. The rainiest months are June and May.
Why should I book my De Soto accommodation with Hotels.com?
There are plenty of reasons to book your De Soto travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.