Hotels in Matthews

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Where to stay in Matthews?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Matthews on Hotels.com. These Matthews hotels consistently deliver on comfort, location and traveler experience. Last updated on August 25, 2026.

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

Hampton Inn Sikeston

Sikeston

CNY684

CNY774 total

includes taxes & fees

Sep 20 - Sep 21

A Holiday Inn Express building with a covered entrance, stone pillars, and multiple windows.

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A buffet with labeled food items and a patterned wall in the background.

A hotel reception area with a reception desk, a large wall clock, and a potted plant.

Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

CNY706

CNY799 total

includes taxes & fees

Aug 30 - Aug 31

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

Drury Inn & Suites Sikeston, MO

Sikeston

CNY632

CNY727 total

includes taxes & fees

Aug 30 - Aug 31

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

Fairfield Inn & Suites by Marriott Sikeston

Sikeston

CNY679

CNY769 total

includes taxes & fees

Sep 13 - Sep 14

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

Best Western Plus Sikeston I-55

Sikeston

CNY600

CNY684 total

includes taxes & fees

Aug 30 - Aug 31

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

Super 8 by Wyndham Sikeston/Miner Area

Sikeston

CNY411

CNY469 total

includes taxes & fees

Aug 27 - Aug 28

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

TownePlace Suites by Marriott Sikeston

Sikeston

CNY793

CNY898 total

includes taxes & fees

Sep 3 - Sep 4

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious lobby with a central atrium, a piano, and a reception desk.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

Days Inn and Suites by Wyndham Sikeston

Sikeston

CNY440

CNY502 total

includes taxes & fees

Aug 30 - Aug 31

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

Comfort Inn & Suites Sikeston I-55

Sikeston

CNY607

CNY692 total

includes taxes & fees

Sep 20 - Sep 21

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

Super 8 By Wyndham Marston

Marston

CNY557

CNY636 total

includes taxes & fees

Aug 27 - Aug 28

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A reception area with a sign for 'Travel Inn and Suites'.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

CNY461

CNY525 total

includes taxes & fees

Aug 27 - Aug 28

A building with a fountain and flower beds in front.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

The Riverstone Hotel Charleston-Sikeston

Charleston

CNY447

CNY496 total

includes taxes & fees

Sep 26 - Sep 27

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a counter, a coffee machine, and seating.

A bathroom with a bathtub, toilet, and shower curtain.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

Country Yard Inn and Suite

Sikeston

CNY399

CNY475 total

includes taxes & fees

Sep 16 - Sep 17

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

Eagle Inn Charleston

Charleston

CNY517

CNY574 total

includes taxes & fees

Sep 26 - Sep 27

A modern hotel lobby with a bar area, seating, and artwork on the walls.

A modern kitchen with a large island, bar stools, wine bottles, and a built-in TV.

A swimming pool with clear blue water, surrounded by sun loungers and a lifeguard stand.

A modern hotel with a prominent sign, a covered entrance, and a well-lit exterior.

Hampton Inn By Hilton Dexter

Dexter

CNY656

CNY736 total

includes taxes & fees

Sep 7 - Sep 8

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A reception area with a counter, a flat-screen TV, and a window with blinds.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

CNY400

CNY444 total

includes taxes & fees

Aug 30 - Aug 31

A diner with booth seating, a checkered floor, and a counter with a cash register.

A reception area with a marble counter, potted plants, a clock, and a TV on the wall.

A hotel room with a bed, a desk, a chair, a large mirror, a sink, and a trash bin.

A gym with multiple exercise machines, a clock on the wall, and a window with blinds.

Travelodge by Wyndham Dexter

Dexter

CNY587

CNY659 total

includes taxes & fees

Sep 6 - Sep 7

A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

A hotel with a brick facade, multiple windows, and a covered entrance area.

A living room with a sofa, a coffee table, a clock, and a painting on the wall.

A hotel reception area with a reception desk, framed certificates, and a painting on the wall.

Econo Lodge Dexter

Dexter

CNY343

CNY385 total

includes taxes & fees

Sep 26 - Sep 27

A hotel room with two beds, a television, a desk, and a mirror.

A hotel room with a dining area, a sofa, and a kitchen counter with appliances.

A bathroom with a sink, mirror, and chair.

A hotel room with a bed, a desk, a television, and a seating area with a small table.

Travel Inn Marston I-55 by Hotel O

Marston

CNY314

CNY359 total

includes taxes & fees

Sep 26 - Sep 27

A coffee shop with a coffee machine, espresso cups, a sink, and a trash bin.

A kitchen with a white microwave, a fruit basket, a coffee maker, and a storage container.

A hotel room with two beds, a desk with a lamp, a chair, a dresser, and a door with a handle.

A hotel hallway with patterned carpet, light green walls, and a ceiling with recessed lighting.

Dexter Inn

Dexter

CNY437

CNY491 total

includes taxes & fees

Aug 27 - Aug 28

View all properties

Go beyond your typical stay in Matthews

Pet friendly

Pool

Family friendly

Check out reviews of Matthews hotels guests love

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"Staff were friendly, room was nice and clean, the breakfast was delicious. Of the three hotels on this trip this was the best one."

Hampton Inn Sikeston

10/10 Excellent

"👍"

Best Western Plus Sikeston I-55

10/10 Excellent

"I really loved everything about my stay and the hotel in general. Nice Job"

Econo Lodge Dexter

10/10 Excellent

"Staff are kind, welcoming and helpful! Property is clean and well. For the pri"

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Great value, very clean and breakfast was actually good."

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"We stay here every time we are in Sikesons. Can't beat this hotel. Super clean 'comfortable!' beds, living room area, and bathrooms. Small hot breakfast. All for the best price out there. Don't skip on this hotel! Staff is always polite and helpful. We always love to walk out to the pond"

Hampton Inn By Hilton Dexter

10/10 Excellent

"Best Hampton Inn that I have ever stayed in. Excellent service and Wonderful staff. Extremely helpful with disabled husband."

Travelodge by Wyndham Dexter

10/10 Excellent

"It’s was clean and very well maintained"

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent

"Nice staff. Very accommodating."

Frequently asked questions

How much does a hotel room cost in Matthews?

You can discover great hotels in Matthews from CNY359 with properties to suit all budgets and needs. If you're looking for an affordable hotel in Matthews that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Matthews hotels?

Discover great deals on Matthews hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on Matthews hotels.

Can I book Matthews hotels with free cancellation?

In order to book a refundable Matthews hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What hotels do travelers like in Matthews?

Guests like Drury Inn & Suites Sikeston, MO, Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55.

Can I book refundable accommodations in Matthews?

If you're looking for the flexibility to change your plans to Matthews, most hotels offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Matthews be like during my vacation?

July and August are typically the warmest months in Matthews when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. April and March are the months with the most rain.

Why should I book my Matthews accommodation with Hotels.com?

There are lots of reasons to book your Matthews trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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