Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Greenville on Hotels.com. These Greenville Business Hotels consistently deliver on quality, location and traveler experience. Last updated on .
Business Hotels in Greenville
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Top 5 Business Hotels in Greenville at a glance
- Embassy Suites Greenville Golf Resort & Conference Center — 3.5-star hotel in Greenville. Guest rating: 9.0/10 — Wonderful.
- Best Western Plus Greenville I-385 Inn & Suites — 2.5-star hotel in Greenville. Guest rating: 9.2/10 — Wonderful.
- SpringHill Suites by Marriott Greenville Downtown — 2.5-star hotel in Greenville Downtown. Guest rating: 9.6/10 — Exceptional.
- La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. — 3-star hotel in Greenville. Guest rating: 8.8/10 — Excellent.
- Hyatt Place Greenville Downtown — 3-star hotel in Greenville Downtown. Guest rating: 9.2/10 — Wonderful.
Business Hotels in Greenville




Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference Center



Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & Suites



SpringHill Suites by Marriott Greenville Downtown
SpringHill Suites by Marriott Greenville Downtown



La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.



Embassy Suites by Hilton Greenville Downtown Riverplace
Embassy Suites by Hilton Greenville Downtown Riverplace



DoubleTree by Hilton Greenville Woodruff Road
DoubleTree by Hilton Greenville Woodruff Road



Hampton Inn & Suites Greenville-Downtown-RiverPlace
Hampton Inn & Suites Greenville-Downtown-RiverPlace



Courtyard by Marriott Greenville Downtown
Courtyard by Marriott Greenville Downtown



Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG



Holiday Inn Express & Suites Greenville - Downtown by IHG
Holiday Inn Express & Suites Greenville - Downtown by IHGTop neighborhoods in Greenville





Greenville Downtown
Greenville's downtown dazzles with the rushing waterfalls of Falls Park and the graceful curve of Liberty Bridge overhead. The tree-lined Main Street feels like a movie set with its mix of historic brick buildings and modern glass facades. Art lovers can hop between galleries, catch a show at the Peace Center, or laugh it up at Alchemy Comedy Theater. Hungry travelers have their pick of farm-to-table restaurants and craft breweries housed in converted textile mills. Most attractions sit within a 6-block radius, making it perfect for exploring on foot. When you need a break, the 26-acre Falls Park offers peaceful riverside paths away from the hustle.

West End
Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river.
Overbrook Historic District
Overbrook Historic District showcases Greenville's architectural heritage through well-preserved Craftsman bungalows and Colonial Revival homes. The neighborhood's tree-lined streets invite leisurely strolls past charming houses with distinctive features and wraparound porches. Arthur Black Park and nearby Swamp Rabbit Trail offer green spaces for nature lovers who appreciate peaceful surroundings. Visitors typically need to venture to downtown Greenville for dining and shopping, just a quick 10-minute drive away. While public transit is limited, street parking is readily available for those with cars. Accommodation options might include historic bed & breakfasts or vacation rentals that highlight the area's authentic residential character.
Hampton-Pinckney Historic District
Payne-Logan
Payne-Logan gives you an authentic slice of Greenville's residential charm without the tourist hustle. This quiet neighborhood trades flashy attractions for leafy streets and genuine local vibes. When you're ready to explore, Bi Lo Center sits nearby, while Fluor Field and The Peace Center are just a short drive away. Perfect for travelers who want to experience real American suburban life. Affordable vacation rentals and occasional bed & breakfasts make this area budget-friendly compared to downtown options. Getting around requires a car for most destinations, though rideshares are readily available. Morning coffee runs might mean driving to nearby commercial areas, but you'll appreciate returning to peaceful tree-lined streets after a day of sightseeing.
Top landmarks in Greenville

Falls Park on the Reedy

The Peace Center

Fluor Field at the West End
Bob Jones University
Bon Secours Wellness Arena
Greenville Convention Center
Haywood Mall
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