Hotels in Byron

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Check prices for these dates

Tonight
Dec 28 - Dec 29
Tomorrow
Dec 29 - Dec 30
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Where to stay in Byron?

Exterior
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
8.8 out of 10, Excellent, (893)
  • cleanliness
    Relax in quiet comfort with Mayo Clinic just a 15-minute walk away from this hotel.
The price is CNY560
CNY645 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top landmarks in Byron

Putting Green

You might want to play some rounds at Putting Green, located 1.2 mi (1.9 km) from central Byron. If Putting Green doesn't quite scratch your golfing itch, Somerby Golf Club, and Links of Byron Mini Golf are also nearby.
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Valley View Park

Valley View Park is worth a visit, located 0.4 mi (0.6 km) from central Byron.
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Check out reviews of Byron hotels guests love

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent
"The room was perfect clean and absolutely perfect "
Emily 1-night trip
Posted 2 days ago
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Frequently asked questions

How much does a hotel room cost in Byron?
You can find top hotels in Byron from CNY473 with options to suit your budget and needs. To find an affordable hotel in Byron that meets all of your requirements, just apply filters on Hotels.com and sort hotels by "Price: low to high".
How can I find deals and earn rewards at Byron hotels?
Discover great deals on Byron hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on Byron hotels.
Can I book Byron hotels with free cancellation?
To book a refundable Byron hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What hotels do travelers recommend in Byron?
Guests like Kahler Grand Hotel, Kahler Inn and Suites - Mayo Clinic Area and Hampton Inn Rochester-South.
Can I book refundable accommodations in Byron?
If you're looking for the flexibility to change your plans to Byron, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Byron be like during my vacation?
July and August are typically the warmest months in Byron when the average temp is 67°F. January and February are the coldest months when the average temperature is 21°F. June and May are the months with the most rain.
Why should I book my Byron hotel with Hotels.com?
There are lots of reasons to book your Byron trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.