Hotels in Puxico

Where to?

Dates

April 2026

May 2026

I'm traveling for business

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Mar 21 - Mar 22

Tomorrow

Mar 22 - Mar 23

Next weekend

Mar 27 - Mar 29

In two weeks

Where to stay in Puxico?

Desk, iron/ironing board, free WiFi, bed sheets

Econo Lodge Dexter

Dexter

Located in Dexter with free WiFi, breakfast, and parking for travelers on the go.

CNY395 total

includes taxes & fees

Apr 20 - Apr 21

Lobby sitting area

EC Reed's Mercantile and Hotel

Marble Hill

Rustic hotel with hiking trails and free perks in the charming town of Marble Hill.

Breakfast, lunch, dinner served; American cuisine

Travelodge by Wyndham Dexter

Dexter

Cozy spot with quick access to local heritage sites and convenient travel amenities.

CNY795 total

includes taxes & fees

Mar 29 - Mar 30

Breakfast area

Dexter Inn

Dexter

Relax in scenic Dexter with free perks and a refreshing seasonal outdoor pool.

CNY465 total

includes taxes & fees

Mar 22 - Mar 23

Desk, iron/ironing board, free WiFi, bed sheets

OYO Hickory House Inn

Dexter

Well-appointed Dexter motel offering free WiFi and parking near local attractions.

CNY442 total

includes taxes & fees

Apr 4 - Apr 5

Lobby

Hampton Inn By Hilton Dexter

Dexter

CNY756 total

includes taxes & fees

Mar 29 - Mar 30

Lobby

Drury Inn & Suites Poplar Bluff

Poplar Bluff

Relax in dual indoor-outdoor pool options in this Poplar Bluff tranquil retreat.

CNY733 total

includes taxes & fees

Apr 12 - Apr 13

Lobby

Comfort Inn Poplar Bluff North

Poplar Bluff

Experience peaceful sleep at this North Main Street hotel with a seasonal pool.

CNY721 total

includes taxes & fees

Apr 12 - Apr 13

Front of property

Lake Wappapello

Williamsville

Serene lake getaway with cozy cabins and nearby historic attractions.

CNY619 total

includes taxes & fees

Apr 1 - Apr 2

Reception

Hampton Inn Poplar Bluff

Poplar Bluff

Experience a comfortable stay minutes from North Main Street Historic District.

CNY729 total

includes taxes & fees

Apr 12 - Apr 13

Lobby

Super 8 by Wyndham Poplar Bluff Missouri

Poplar Bluff

Enjoy a bright, well-maintained base for exploring Poplar Bluff's charms.

CNY431 total

includes taxes & fees

Apr 12 - Apr 13

Breakfast, lunch, dinner served; Italian cuisine

Holiday Inn Poplar Bluff by IHG

Poplar Bluff

Relaxing retreat near historic district with Italian dining and peaceful indoor pool.

CNY850 total

includes taxes & fees

Mar 22 - Mar 23

Lobby lounge

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Relax at the stylish riverside hotel with 24-hour fitness and indoor pool access.

CNY858 total

includes taxes & fees

Apr 2 - Apr 3

Coffee service

Motel 6 Poplar Bluff, MO

Poplar Bluff

Experience clean comfort near North Main Street Historic District and art museum.

CNY532 total

includes taxes & fees

Mar 22 - Mar 23

View all properties

Go beyond your typical stay in Puxico

Family friendly

Pool

Learn more about Puxico

Puxico is well-known for its attractions such as Mark Twain National Forest and Mingo Wilderness.

See all hotels in Puxico

Great place for sunrises, Bald Eagles in the winter, and Milkyway shots.

Check out reviews of Puxico hotels guests love

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

8/10 Good

"Clean room, staff was super helpful"

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

10/10 Excellent

"Our stay was good and the room was clean. The only issue we ran into was that room was next to the water pumps and there was a good bit of background noise throughout the night. Other than that everything was great. The breakfast in the morning was good and there were enough choices for everyone to find something they liked and feel satisfied. The location is very good with a Walmart and some other stores and restaurants very close by."

Frequently asked questions

How much does a hotel room cost in Puxico?

You can find top hotels in Puxico from CNY395 with options to suit your budget and needs. If you're looking for an affordable hotel in Puxico that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Puxico hotels?

Discover great deals on Puxico hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on Puxico hotels.

Can I book Puxico hotels with free cancellation?

To book a refundable Puxico hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What hotels do travelers like in Puxico?

Guests like 'the Lakehouse' Lovely Wappapello Country Home!.

Can I book a refundable accommodation in Puxico?

If you want the flexibility to change your travel plans to Puxico, most accommodations provide refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Puxico be like during my visit?

The warmest months in Puxico are usually July and August with an average temp of 77°F. January and February are the chilliest months when the average temp is 41°F. The rainiest months are April and May.

Why should I book my Puxico hotel through Hotels.com?

There are plenty of reasons to book your Puxico travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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