Hotels in Prairie Home

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Where to stay in Prairie Home?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Prairie Home on Hotels.com. These Prairie Home hotels consistently deliver on quality, location and traveler experience. Last updated on September 30, 2026.

A swimming pool area with a covered bench, a chair, and a sign indicating pool rules.

A hotel room with a desk, two chairs, a printer, a phone, a framed picture, and a 'No Smoking' sign.

A modern room with a blue wall, a gray sofa, a wooden coffee table, and a yellow chair.

A coffee station with two coffee machines and a variety of coffee pods and cups.

1. Holiday Inn Express Boonville by IHG

Boonville

CNY906

CNY1,161 total

includes taxes & fees

Oct 4 - Oct 5

A patio area with a fire pit, outdoor seating, and a grill.

A modern building with a 'park' sign, stone facade, and outdoor seating area.

A modern kitchen with built-in appliances, a wooden countertop, and a seating area with a chair.

A modern dining area with a long wooden table, multiple chairs, a flat-screen TV mounted on a stone wall, and a fireplace.

2. TownePlace Suites by Marriott Columbia

Columbia

CNY791

CNY902 total

includes taxes & fees

Oct 18 - Oct 19

A hotel lobby with a reception desk, seating area, and a reception counter.

A compact hotel room with a flat-screen TV, a microwave, a refrigerator, a bench, and a small table.

A gym with a treadmill, exercise bike, and weight machine.

A hotel room with two beds, a nightstand, a lamp, and a patterned carpet.

3. Baymont by Wyndham Columbia, MO

Columbia

CNY399

CNY451 total

includes taxes & fees

Oct 11 - Oct 12

A modern office space with a meeting area featuring a large table and chairs, a purple accent wall, and a view through large windows.

A modern office space with a desk area, seating, and a hanging chair.

4. Tru By Hilton Columbia South

Columbia

CNY599

CNY683 total

includes taxes & fees

Oct 25 - Oct 26

A casino with multiple gaming machines, an ATM, and a staircase leading to upper levels.

An outdoor patio with a fire feature, seating, and hanging flower baskets.

A spacious lobby with a patterned carpet, multiple seating areas including sofas and chairs, and a large chandelier.

A restaurant interior with a unique hanging light fixture made of bottles, brick walls, and wooden furniture.

5. Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

Boonville

CNY457

CNY601 total

includes taxes & fees

Oct 14 - Oct 15

An indoor swimming pool with lounge chairs and a hot tub, surrounded by wooden walls and windows.

A hotel with an indoor pool, featuring a prominent sign and a brick facade.

A hotel lobby with a sofa, chairs, a table, and a patterned carpet.

A hotel room with a desk, computer, and a sofa. There is a dining area in the background with chairs and tables.

6. Quality Inn & Suites Boonville - Columbia

Boonville

CNY667

CNY756 total

includes taxes & fees

Oct 27 - Oct 28

A modern lobby with a sectional sofa, a flat-screen TV, and a glass wall offering a view of the city.

A gym with treadmills, elliptical machines, and a bench.

An indoor swimming pool with clear glass walls, a tiled floor, and a seating area with chairs and tables.

A restaurant interior with booths and tables, blue cushioned chairs, and framed pictures on the walls.

7. Drury Inn & Suites Columbia Stadium Boulevard

Columbia

CNY671

CNY758 total

includes taxes & fees

Oct 18 - Oct 19

A covered outdoor seating area with wooden beams and a lantern, overlooking a brick building and greenery.

A modern interior with a seating area, wooden partitions, and large windows.

A hotel room with a bed, a chair, a floor lamp, and a painting on the wall.

A formal dining table set with crystal glassware, plates, and napkins, with a decorative crystal centerpiece.

8. Courtyard by Marriott Columbia Missouri

Columbia

CNY764

CNY863 total

includes taxes & fees

Oct 11 - Oct 12

A spacious living area with a blue sofa, leather armchairs, and a flat-screen TV mounted on a wooden cabinet. Large windows provide a view of parked cars outside.

A hotel room with a large bed, a desk, a chair, a lamp, and a window with curtains.

A hotel room with a large flat-screen TV, two beds, a sofa, and a desk.

A restaurant with multiple tables and chairs, a counter with a coffee machine, and a menu board.

9. Comfort Suites Columbia - University Area

Columbia

CNY658

CNY743 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a bed, a sofa, a television, and a large window with curtains.

A hotel lobby with a reception desk, a framed welcome sign, and a large window with curtains.

A hotel room with a bed, two bedside tables, a window with curtains, a wall-mounted air conditioner, and a large picture of a boat on the wall.

A motel with a covered parking area, multiple rooms, and a visible sign for a nearby Super 8 motel.

10. Super 8 by Wyndham Boonville

Boonville

CNY483

CNY547 total

includes taxes & fees

Oct 6 - Oct 7

A hotel entrance with a covered walkway, a brick facade, and a well-lit exterior.

A buffet with labeled containers of omelets and other food items.

A hotel room with two desks, each with a laptop and a chair, and a small cabinet.

A large indoor swimming pool with multiple lanes, surrounded by lounge chairs and tables.

11. Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

Columbia

CNY792

CNY898 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor seating area with tables and chairs, a bar, and a fire pit.

A modern lobby with a stone wall, a fireplace, seating areas, and a reception desk.

A multi-story hotel with a prominent entrance, a covered area, and a clear sky at dusk.

A modern restaurant with a bar area, red leather chairs, and a large mural on the wall.

12. The Broadway Columbia - a DoubleTree by Hilton

Columbia

CNY1,043

CNY1,184 total

includes taxes & fees

Nov 1 - Nov 2

13. Hotel Frederick

Boonville

CNY826

CNY935 total

includes taxes & fees

Oct 27 - Oct 28

A hotel room with a dining area, a sofa, a TV, and a view of the city.

A hotel lobby with a staircase, a bar area, and seating.

A Wyndham hotel with a prominent illuminated sign, a covered entrance, and a parking area.

A banquet hall with round tables set for a formal event, featuring a patterned carpet and a high ceiling with chandeliers.

14. Wyndham Executive Center Columbia

Columbia

CNY779

CNY880 total

includes taxes & fees

Oct 13 - Oct 14

A modern hotel lobby with a large TV screen, a reception desk, and a decorative plant display.

A grand lobby with a large TV screen, a chandelier, and a blue sofa.

An outdoor cafe area with tables and chairs, surrounded by greenery and a sign for 'Glenn's Cafe'.

A theater with a marquee reading "TIGER" and a sign for "The Tiger Hotel."

15. voco The Tiger Hotel Columbia, MO by IHG

Columbia

CNY966

CNY1,201 total

includes taxes & fees

Nov 1 - Nov 2

A lobby with a reception desk, two sofas, a coffee table, and a patterned rug.

A hotel room with a bed, a dining table with chairs, a sofa set, a small table, and a kitchenette.

A hotel room with a large bed, a desk with a flat-screen TV, a chair, a desk lamp, and a nightstand with a lamp.

An indoor swimming pool with clear water, surrounded by white walls and a tiled floor.

16. Wingate by Wyndham - Columbia

Columbia

CNY577

CNY652 total

includes taxes & fees

Oct 11 - Oct 12

A spacious bar area with high tables and chairs, a large flat-screen TV mounted on the wall, and a bar stocked with bottles.

A hotel room with a sofa, a green ottoman, a desk with a lamp, and a framed cityscape picture on the wall.

An indoor swimming pool with a tiled floor, a glass barrier, and a lifeguard chair.

A hotel room with two beds, a large window with curtains, and a carpeted floor.

17. Drury Plaza Hotel Columbia East

Columbia

CNY684

CNY773 total

includes taxes & fees

Oct 11 - Oct 12

A modern living room with grey sofas, a coffee table, and a fireplace. There are framed pictures on the wall and a floor lamp.

A large indoor swimming pool with a tiled edge, a metal ladder, and lounge chairs around the perimeter.

A modern restaurant with blue cabinets, wooden tables and chairs, and a kitchen area with appliances.

A hotel room with a large bed, a desk with a lamp, a kitchenette, and a bathroom.

18. Country Inn & Suites by Radisson, Columbia, MO

Columbia

CNY564

CNY638 total

includes taxes & fees

Nov 1 - Nov 2

A modern interior with round tables and chairs, a bar area, and a large window offering a view of the outside.

A patio area with outdoor seating, a pool, and a stone building facade.

A modern lounge area with a sofa, round tables, and chairs, a kitchen area, and large windows.

A modern lobby with a sofa, chairs, a table, a TV, and a reception desk.

19. Best Western Plus Columbia Inn

Columbia

CNY548

CNY620 total

includes taxes & fees

Oct 29 - Oct 30

An indoor swimming pool with clear signage indicating no lifeguard on duty and no diving.

A Hampton Inn & Suites hotel with a brick facade, a covered entrance, and a parking lot.

A reception desk with a wooden finish and granite counter, a framed welcome sign, and a lamp.

A wedding reception table with a tiered white cake, floral decorations, and a menu stand.

20. Hampton Inn & Suites Columbia at University

Columbia

CNY707

CNY799 total

includes taxes & fees

Nov 1 - Nov 2

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Go beyond your typical stay in Prairie Home

Pet friendly

Pool

Hot tub

Family friendly

Check out reviews of Prairie Home hotels guests love

Stoney Creek Hotel Columbia

10/10 Excellent

"This is a unique style place with solid service."

Tru By Hilton Columbia South

10/10 Excellent

"Great new hotel. Close to the Ganz Creek Cross Country course!"

Holiday Inn Columbia East by IHG

10/10 Excellent

"Great experience! Enjoyed our stay."

Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

8/10 Good

"Hotel is nice. Rooms are fairly clean. Bathroom was outdated and had limited space to place toiletries. But close to campus !"

Drury Plaza Hotel Columbia East

10/10 Excellent

"Excellent hotel. Both breakfast and the free supper were great. Friendly staff. Clean, well maintained property. The pool is a bit boring, especially if the divider is closed. Pool is 3 ft deep on both ends, and 5 ft in the middle."

Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

10/10 Excellent

"Room was clean and the bed very comfortable."

Wyndham Executive Center Columbia

10/10 Excellent

"Great location good experience"

The Broadway Columbia - a DoubleTree by Hilton

10/10 Excellent

"Getting between towers and to higher parking levels was not easy with luggage. We ended up having to park on top level and had difficulty with elevator and had to walk up last 2 levels when leaving."

Quality Inn & Suites Columbia I-70

10/10 Excellent

"Standard amenities. Parking lot is a little small"

Frequently asked questions

How much does a hotel room cost in Prairie Home?

You can find top hotels in Prairie Home from CNY316 with options to suit your budget and needs. If you're after an affordable hotel in Prairie Home that meets all of your requirements, set your filters and then sort the results by "Price: low to high".

How can I find deals and earn rewards at Prairie Home hotels?

Discover great deals on Prairie Home hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. And make sure to check out our last-minute deals on Prairie Home hotels.

Can I book Prairie Home hotels with free cancellation?

In order to book a refundable Prairie Home hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

Can I book a refundable hotel in Prairie Home?

If you want the flexibility to change your travel plans to Prairie Home, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Prairie Home be like during my trip?

The warmest months in Prairie Home are usually July and August with an average temp of 75°F. January and February are the chilliest months when the average temp is 36°F. The rainiest months are May and April.

Why should I book my Prairie Home hotel with Hotels.com?

There are plenty of reasons to book your Prairie Home travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Hotels in Prairie Home

Room 1

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Prairie Home?

1. Holiday Inn Express Boonville by IHG

2. TownePlace Suites by Marriott Columbia

3. Baymont by Wyndham Columbia, MO

4. Tru By Hilton Columbia South

5. Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

6. Quality Inn & Suites Boonville - Columbia

7. Drury Inn & Suites Columbia Stadium Boulevard

8. Courtyard by Marriott Columbia Missouri

9. Comfort Suites Columbia - University Area

10. Super 8 by Wyndham Boonville

11. Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

12. The Broadway Columbia - a DoubleTree by Hilton

13. Hotel Frederick

14. Wyndham Executive Center Columbia

15. voco The Tiger Hotel Columbia, MO by IHG

16. Wingate by Wyndham - Columbia

17. Drury Plaza Hotel Columbia East

18. Country Inn & Suites by Radisson, Columbia, MO

19. Best Western Plus Columbia Inn

20. Hampton Inn & Suites Columbia at University

Go beyond your typical stay in Prairie Home

Check out reviews of Prairie Home hotels guests love

Stoney Creek Hotel Columbia

Tru By Hilton Columbia South

Holiday Inn Columbia East by IHG

Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG

Drury Plaza Hotel Columbia East

Isle of Capri Casino Hotel Boonville & Casino - A Caesars Rewards Destination

Wyndham Executive Center Columbia

The Broadway Columbia - a DoubleTree by Hilton

Quality Inn & Suites Columbia I-70

Frequently asked questions

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