Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
If you're planning a bit of sightseeing during your trip, head to King Neptune Memorial— just one of the landmarks located 6.3 mi (10.1 km) from central Anna.
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
"This is the best hotel experience for the price that I’ve ever had, and I travel a lot. Very generous social time with three free drinks and lots of complementary food. Everyone was lovely, bed comfortable, perfect temperature and no stale smell. Very clean. And so well priced! I wish all hotels were like this one!"
"Beautiful hotel. Very clean, modern and friendly staff. Definitely would recommend to anyone coming to that area and will stay there every time we visit the city."
If you want the flexibility to change your travel plans to Anna, most properties offer refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in Anna if I want a vacation rental instead of a traditional hotel?
If you're looking for a good alternative to a hotel, browse our selection of 5 vacation homes. You can also book one of the 5 cabins for your stay.
What will the weather in Anna be like during my vacation?
The warmest months in Anna are usually July and August with an average temp of 75°F. January and February are the chilliest months when the average temp is 39°F. The rainiest months are April and March.
Why should I book my Anna accommodation with Hotels.com?
There are plenty of reasons to book your Anna travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.
