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Vacation homes in Saint Helena Island
Properties are selected based on real traveler reviews and popularity among guests who’ve booked a vacation rental stay in Saint Helena Island on Hotels.com. These Saint Helena Island vacation rentals consistently deliver on quality, location and traveler experience. Last updated on September 11, 2026.
1. Beachy Home in Heart of Beaufort w/ Pool Access
Beachy Home in Heart of Beaufort w/ Pool AccessNorthwest Quadrant
2. Hunt, Fish & Relax: Rural Retreat in Green Pond
Hunt, Fish & Relax: Rural Retreat in Green PondJacksonboro
3. Saint Helena Island Getaway w/ Marsh Views!
Saint Helena Island Getaway w/ Marsh Views!Saint Helena Island
4. Downtown Home w/ Yard & BBQ - 6 Mi to Downtown!
Downtown Home w/ Yard & BBQ - 6 Mi to Downtown!Beaufort
5. 11 Mi to Hunting Island State Park! Family Home
11 Mi to Hunting Island State Park! Family HomeSaint Helena Island
6. Waterfront Home on Dataw Island: Golf & Amenities!
Waterfront Home on Dataw Island: Golf & Amenities!Saint Helena Island
7. Family Retreat in Beaufort: 3 Mi to Historic Dtwn
Family Retreat in Beaufort: 3 Mi to Historic DtwnBeaufort
8. Home in Beaufort Historic District w/ Private Yard
Home in Beaufort Historic District w/ Private YardHistoric District
9. Spacious Riverfront Cottage w/ Dock in Green Pond!
Spacious Riverfront Cottage w/ Dock in Green Pond!Jacksonboro
10. Rustic Beaufort Home w/ Stunning Marsh Views!
Rustic Beaufort Home w/ Stunning Marsh Views!Beaufort
Top neighborhoods in Saint Helena Island
Top landmarks in Saint Helena Island
Penn Center
8.0/10 (7 reviews)
Penn Center is 1.4 mi (2.3 km) from central Saint Helena Island, why not stop by during your stay. If you want to experience more of the culture Saint Helena Island has to offer, head to Red Piano Too Gallery, Horse Island, and York W. Bailey Museum.
Red Piano Too Gallery
5.4/10 (3 reviews)
Art fans might want to browse the collections at Red Piano Too Gallery in Saint Helena Island. If you want to experience more of the culture Saint Helena Island has to offer, head to Penn Center, Coosaw Island, and Horse Island.
Fort Fremont
7.8/10 (8 reviews)
If seeing the sights is on your list of things to do, head to Fort Fremont— just one of the landmarks located 8.1 mi (13.1 km) from central Saint Helena Island. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches.
Horse Island
Horse Island is 3.4 mi (5.5 km) from central Saint Helena Island, why not stop by during your stay.
Chapel of Ease
8.4/10 (7 reviews)
If you're interested in local churches, head to Chapel of Ease located 2 mi (3.2 km) from central Saint Helena Island.
York W. Bailey Museum
6.0/10 (3 reviews)
York W. Bailey Museum is 1.4 mi (2.3 km) from central Saint Helena Island, why not stop by during your stay. If you want to experience more of the culture Saint Helena Island has to offer, head to Penn Center, Red Piano Too Gallery, and Horse Island.
Butchers Island
Butchers Island is 5.4 mi (8.8 km) from central Saint Helena Island, why not stop by during your stay.
Sheep Island
Sheep Island is 5.2 mi (8.4 km) from central Saint Helena Island, why not stop by during your stay.
Learn more about Saint Helena Island
Saint Helena Island is applauded for its cultural attractions such as Penn Center and Red Piano Too Gallery. The city has something for everyone including sights like Horse Island and Fort Fremont within a rural setting.
See all hotels in Saint Helena Island
About the destination
If you're looking for a place to get away, look no further than Saint Helena Island. Whether you're planning to stay for a night or for the week, the area around Saint Helena Island has accommodations to fit every need. Search for hotels in Saint Helena Island with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Saint Helena Island hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Saint Helena Island hotel deals are here with our lowest price guarantee.
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