Hotels in Southeast Missouri

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Tonight
Jun 24 - Jun 25
Tomorrow
Jun 25 - Jun 26
This weekend
Jun 27 - Jun 29
Next weekend
Jul 4 - Jul 6

Where to stay in Southeast Missouri?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1000)
The price is CNY790
CNY891 total
includes taxes & fees
Jul 18 - Jul 19
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Jul 4 - Jul 6

Image gallery for Century Casino & Hotel Caruthersville

Room

Century Casino & Hotel Caruthersville

2.0 star property
Caruthersville
8.4/10Very Good (37 reviews)
10% off
CNY2,129 total
includes taxes & fees
Price is CNY936
Century Casino & Hotel Caruthersville

Top landmarks in Southeast Missouri

Echo Bluff is Missouri's newest State Park.

Echo Bluff State Park

Travelers who enjoy the great outdoors might want to go to Echo Bluff State Park, located 24.3 mi (39 km) from central Salem. If you like Echo Bluff State Park and want to stay outside, head to Ozark National Scenic Riverways which is also in Salem.

See properties in Echo Bluff State Park
Echo Bluff State Park

Learn more about Southeast Missouri

Southeast Missouri is well-known for its wineries and riverfront while attractions include Sam A. Baker State Park and K Bridge Recreation Area. This family-friendly city has something for everyone including its university life, restaurants, and sights like Lake Wappapello State Park and Clearwater Lake.

See all hotels in Southeast Missouri

Check out the Southeast Missouri hotels guests love right now

Best Western Plus Sikeston

Best Western Plus Sikeston

10/10 Excellent
"Very clean. Beautifully decorated. Good breakfast. Great location to everything we wanted to do. "
Theresa 2-night trip
Posted 1 day ago
Best Western Plus Sikeston

Frequently asked questions

Can I book a refundable accommodation in Southeast Missouri?
If you need the flexibility to change your travel plans to Southeast Missouri, most hotels provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Southeast Missouri if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, look over our selection of 129 vacation homes. In addition, there are 46 apartments and 7 condos.
Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.