Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Southern Illinois on Hotels.com. These Southern Illinois hotels consistently deliver on comfort, location and traveler experience. Last updated on .
Photo by Southernmost Illinois Tourism Bureau
Hotels in Southern Illinois
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Aug 13 - Aug 14Tomorrow
Aug 14 - Aug 15This weekend
Aug 14 - Aug 16Next weekend
Aug 21 - Aug 23Where to stay in Southern Illinois?
Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. VernonMount Vernon
CNY749
CNY844 total
includes taxes & fees
Aug 23 - Aug 24
Holiday Inn Express & Suites Mount Vernon by IHG
Holiday Inn Express & Suites Mount Vernon by IHGMount Vernon
CNY749
CNY844 total
includes taxes & fees
Sep 13 - Sep 14
Comfort Suites Mount Vernon
Comfort Suites Mount VernonMount Vernon
CNY793
CNY894 total
includes taxes & fees
Aug 16 - Aug 17
DoubleTree by Hilton Mt. Vernon
DoubleTree by Hilton Mt. VernonMount Vernon
CNY863
CNY971 total
includes taxes & fees
Sep 4 - Sep 5
Super 8 by Wyndham Mt. Vernon IL
Super 8 by Wyndham Mt. Vernon ILMount Vernon
CNY461
CNY526 total
includes taxes & fees
Aug 16 - Aug 17
Best Western Plus Centralia Hotel & Suites
Best Western Plus Centralia Hotel & SuitesCentralia
CNY1,005
CNY1,125 total
includes taxes & fees
Aug 16 - Aug 17
Quality Inn Mount Vernon, IL
Quality Inn Mount Vernon, ILMount Vernon
CNY503
CNY572 total
includes taxes & fees
Sep 13 - Sep 14
SureStay Hotel by Best Western Whittington Rend Lake
SureStay Hotel by Best Western Whittington Rend LakeWhittington
CNY546
CNY606 total
includes taxes & fees
Aug 20 - Aug 21
Days Inn by Wyndham Mount Vernon
Days Inn by Wyndham Mount VernonMount Vernon
CNY487
CNY554 total
includes taxes & fees
Sep 14 - Sep 15
Hampton Inn & Suites Effingham
Hampton Inn & Suites EffinghamEffingham
CNY824
CNY915 total
includes taxes & fees
Sep 6 - Sep 7
Drury Inn & Suites Marion
Drury Inn & Suites MarionMarion
CNY668
CNY801 total
includes taxes & fees
Aug 20 - Aug 21
Holiday Inn Express & Suites Vandalia by IHG
Holiday Inn Express & Suites Vandalia by IHGVandalia
Holiday Inn Express & Suites Vandalia by IHG
La Quinta Inn & Suites by Wyndham Effingham
La Quinta Inn & Suites by Wyndham EffinghamEffingham
CNY694
CNY777 total
includes taxes & fees
Aug 23 - Aug 24
Best Western Delta Inn
Best Western Delta InnEffingham
CNY596
CNY668 total
includes taxes & fees
Aug 23 - Aug 24
Comfort Inn & Suites Marion I-57
Comfort Inn & Suites Marion I-57Marion
CNY789
CNY947 total
includes taxes & fees
Sep 9 - Sep 10
Cobblestone Inn & Suites - Altamont
Cobblestone Inn & Suites - AltamontAltamont
CNY728
CNY787 total
includes taxes & fees
Aug 16 - Aug 17
Best Western Plus MidAmerica Hotel
Best Western Plus MidAmerica HotelMascoutah
CNY798
CNY910 total
includes taxes & fees
Aug 27 - Aug 28
Fairfield by Marriott Inn & Suites Mattoon
Fairfield by Marriott Inn & Suites MattoonMattoon
CNY740
CNY843 total
includes taxes & fees
Aug 23 - Aug 24
Suite Dreams Hotel
Suite Dreams HotelMattoon
CNY641
CNY718 total
includes taxes & fees
Sep 14 - Sep 15
Baymont by Wyndham Marion
Baymont by Wyndham MarionMarion
CNY595
CNY714 total
includes taxes & fees
Aug 16 - Aug 17
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We have 1 left at
La Quinta Inn & Suites by Wyndham EffinghamCNY923
per night
CNY1,033 total
includes taxes & fees
We have 2 left at
Walker's Bluff Casino ResortCNY1,062
per night
CNY1,179 total
includes taxes & fees
CNY1,250
per night
CNY1,387 total
includes taxes & fees
Sign in for extra savings
We have 1 left at
Bel Air MotelCNY534
per night
CNY654 total
includes taxes & fees
We have 1 left at
Makanda InnCNY2,033
per night
CNY2,318 total
includes taxes & fees
CNY76 off
Quality Inn O'Fallon - St. Louis - ShilohCNY431
per night
CNY495 total
includes taxes & fees
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
Harrah's Metropolis Hotel & Casino - A Caesars Rewards DestinationMetropolis
CNY980 off
Harrah's Metropolis Hotel & Casino - A Caesars Rewards DestinationCNY1,819
per night
CNY2,127 total
includes taxes & fees
La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
La Quinta Inn & Suites by Wyndham Collinsville - St. LouisEastport
CNY722
per night
CNY831 total
includes taxes & fees
Sign in for extra savings
We have 5 left at
Fairfield by Marriott Inn & Suites MattoonCNY854
per night
CNY1,947 total
includes taxes & fees
We have 2 left at
La Quinta Inn & Suites by Wyndham EffinghamCNY840
per night
CNY1,881 total
includes taxes & fees
We have 1 left at
Makanda InnCNY1,497
per night
CNY3,413 total
includes taxes & fees
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
Harrah's Metropolis Hotel & Casino - A Caesars Rewards DestinationMetropolis
CNY1,291 off
Harrah's Metropolis Hotel & Casino - A Caesars Rewards DestinationCNY1,198
per night
CNY2,876 total
includes taxes & fees
We have 3 left at
Bel Air MotelCNY534
per night
CNY1,307 total
includes taxes & fees
We have 1 left at
Riverview Mansion HotelCNY844
per night
CNY2,590 total
includes taxes & fees
Radisson Hotel Fairview Heights - St. Louis
Radisson Hotel Fairview Heights - St. LouisFairview Heights
We have 2 left at
Radisson Hotel Fairview Heights - St. LouisCNY740
per night
CNY1,671 total
includes taxes & fees
CNY155 off
Quality Inn O'Fallon - St. Louis - ShilohCNY439
per night
CNY1,010 total
includes taxes & fees
La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
La Quinta Inn & Suites by Wyndham Collinsville - St. LouisEastport
CNY745
per night
CNY1,714 total
includes taxes & fees
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Check out hotels with a hot tub in Southern Illinois
CNY749
CNY844 total
includes taxes & fees
Aug 23 - Aug 24
CNY825
CNY929 total
includes taxes & fees
Aug 23 - Aug 24
CNY844
CNY936 total
includes taxes & fees
Sep 14 - Sep 15
CNY596
CNY668 total
includes taxes & fees
Aug 23 - Aug 24
CNY742
CNY831 total
includes taxes & fees
Sep 13 - Sep 14
CNY631
CNY725 total
includes taxes & fees
Aug 30 - Aug 31
CNY379
CNY416 total
includes taxes & fees
Aug 27 - Aug 28
Quality Inn & Suites Vandalia near I-70 and Hwy 51
Quality Inn & Suites Vandalia near I-70 and Hwy 51Vandalia
CNY481
CNY524 total
includes taxes & fees
Aug 23 - Aug 24
Holiday Inn Express Hotel & Suites Sparta by IHG
Holiday Inn Express Hotel & Suites Sparta by IHGSparta
CNY661
CNY734 total
includes taxes & fees
Sep 13 - Sep 14
CNY683
CNY758 total
includes taxes & fees
Sep 13 - Sep 14
You may also like pet-friendly hotels in Southern Illinois
CNY749
CNY844 total
includes taxes & fees
Aug 23 - Aug 24
CNY825
CNY929 total
includes taxes & fees
Aug 23 - Aug 24
CNY461
CNY526 total
includes taxes & fees
Aug 16 - Aug 17
SureStay Hotel by Best Western Whittington Rend Lake
SureStay Hotel by Best Western Whittington Rend LakeWhittington
CNY546
CNY606 total
includes taxes & fees
Aug 20 - Aug 21
CNY487
CNY554 total
includes taxes & fees
Aug 16 - Aug 17
CNY809
CNY907 total
includes taxes & fees
Aug 23 - Aug 24
CNY1,005
CNY1,125 total
includes taxes & fees
Aug 17 - Aug 18
CNY596
CNY668 total
includes taxes & fees
Aug 23 - Aug 24
CNY705
CNY846 total
includes taxes & fees
Aug 23 - Aug 24
CNY728
CNY787 total
includes taxes & fees
Aug 16 - Aug 17
You can also stay at hotels with a pool in Southern Illinois
CNY749
CNY844 total
includes taxes & fees
Aug 23 - Aug 24
Holiday Inn Express & Suites Mount Vernon by IHG
Holiday Inn Express & Suites Mount Vernon by IHGMount Vernon
CNY749
CNY844 total
includes taxes & fees
Sep 13 - Sep 14
CNY825
CNY929 total
includes taxes & fees
Aug 23 - Aug 24
CNY863
CNY971 total
includes taxes & fees
Sep 4 - Sep 5
Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
Fairfield Inn & Suites by Marriott Mt. Vernon Rend LakeMount Vernon
CNY801
CNY902 total
includes taxes & fees
Sep 13 - Sep 14
CNY487
CNY554 total
includes taxes & fees
Aug 16 - Aug 17
CNY844
CNY936 total
includes taxes & fees
Sep 14 - Sep 15
CNY1,005
CNY1,125 total
includes taxes & fees
Aug 17 - Aug 18
Country Inn & Suites by Radisson, Effingham, IL
Country Inn & Suites by Radisson, Effingham, ILEffingham
CNY561
CNY623 total
includes taxes & fees
Sep 6 - Sep 7
CNY596
CNY668 total
includes taxes & fees
Aug 23 - Aug 24
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all propertiesGo beyond your typical stay in Southern Illinois
Family friendly
Pet friendly
Apartment
Cottage
Top landmarks in Southern Illinois
Garden of the Gods Recreation Area
9.8/10 (63 reviews)
Garden of the Gods Recreation Area is 9.3 mi (14.9 km) from central Equality, why not stop by during your stay.
O'Fallon Family Sports Park
8.6/10 (137 reviews)
O'Fallon Family Sports Park is 1.3 mi (2 km) from central O'Fallon, why not stop by during your stay. Want to stretch your legs some more? Head to Shiloh Dog Park and Pleasant Ridge Park, both nearby.
World Wide Technology Raceway
9.0/10 (2 reviews)
Wanna race? You could pay a visit to World Wide Technology Raceway 4.2 mi (6.8 km) from the center of St. Louis. If you think World Wide Technology Raceway is cool, you also might like Busch Stadium and Dome at America’s Center, both located nearby.
DuQuoin State Fairgrounds
8.2/10 (95 reviews)
You can catch an event at DuQuoin State Fairgrounds, located 1.2 mi (1.9 km) from central Du Quoin.
Learn more about Southern Illinois
Southern Illinois is applauded for its entertainment and live music with such cultural attractions as Effingham Performance Center and Lincoln Log Cabin. Visitors highlight this family-friendly city's sports while sights include Jefferson County Fairgrounds and King City Square Shopping Center.
See all hotels in Southern Illinois
Photo by Southernmost Illinois Tourism Bureau
Check out reviews of Southern Illinois hotels guests love
Drury Plaza Hotel Mt. Vernon
10/10 Excellent
"Bathroom design is excellent with low bathtub and apple space. The night buffet dinner is a great idea. The dinner menu was simple but very healthy. Breakfast was good too"
Holiday Inn Express Metropolis by IHG
10/10 Excellent
"The room was clean, quiet and comfortable. We stayed 7 night and had everything we needed. The breakfast was excellent! We only had one problem and that was with the room key cards. They constantly stopped working and we had to have them reprogramed almost daily. Once they came to the room and cleaned the door lock, it slowed down the problem. We will definitely stay here on our return trips to Illinois. The staff was always friendly and very accommodating!!!"
Comfort Suites Mount Vernon
10/10 Excellent
"our room was good sized with a comfortable bed well maintained and clean"
Comfort Inn Edwardsville - St. Louis
10/10 Excellent
"I had a wonderful experience staying at the Comfort Inn during my daughter’s move-in day at SIUE. The hotel was clean, comfortable, and welcoming from the moment we arrived. The guests were friendly, and the team members were very nice and helpful. I highly recommend the Comfort Inn to anyone visiting the Edwardsville/SIUE area. Thank you to the entire team for making our stay such a pleasant one!"
Best Western St. Louis Fairview Heights
8/10 Good
"The one thing I did not like was the lack of a soft drink machine or a snack machine without going to another hotel."
Drury Inn & Suites Marion
10/10 Excellent
"The room was clean, the staff was very friendly. Pool and hot tub was clean and nice. The breakfast, dinner and drinks were good. Love the afternoon popcorn as well."
Comfort Suites Fairview Heights - St. Louis
8/10 Good
"Service was good. Rooms were as expected for the price. However, one room had a bad smell that I think was coming from the tub. Swimming pool was not good. Very cloudy water and smelled of algae. Overall not bad for the price."
Frequently asked questions
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