Hotels in Upstate South Carolina

Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices

Check prices for these dates

Tonight
May 19 - May 20
Tomorrow
May 20 - May 21
This weekend
May 23 - May 25
Next weekend
May 30 - Jun 1

Where to stay in Upstate South Carolina?

Sleep Inn
Lobby

Sleep Inn

2.5 star property
5.8 out of 10, (479)
The price is CNY483
CNY537 total
includes taxes & fees
May 25 - May 26
Sleep Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Upstate South Carolina, SC

Showing deals for:May 30 - Jun 1

Image gallery for Cambria Hotel Greenville

Lobby

Cambria Hotel Greenville

3.0 star property
Greenville
9.4/10Exceptional (1,037 reviews)
15% off
Price is CNY944
per night
CNY2,077 total
includes taxes & fees
Cambria Hotel Greenville

Top neighborhoods in Upstate South Carolina

Default Image

Green Avenue

The Green Avenue neighborhood offers attractions such as Falls Park on the Reedy and Greenville Zoo.

See properties in Green Avenue
Green Avenue

Top landmarks in Upstate South Carolina

Clemson University

Clemson University

If you'd like to get a taste of Clemson student life, check out Clemson University, located 0.5 mi (0.9 km) from central Clemson.

See properties in Clemson University
Clemson University

Learn more about Upstate South Carolina

Upstate South Carolina is applauded for its cultural attractions such as Heritage Park and Roper Mountain Science Center.

See all hotels in Upstate South Carolina
Greenville - Spartanburg showing a sunset, tranquil scenes and mountains
Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism

Frequently asked questions

Can I book a refundable hotel in Upstate South Carolina?
If you’re looking for the flexibility to change your travel plans to Upstate South Carolina, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay in Upstate South Carolina if I want a vacation rental instead of a traditional hotel?
If you’re looking for a good alternative to a hotel, review our selection of 1073 vacation homes. In addition, there are 111 apartments and 92 condos.
Why should I book my Upstate South Carolina hotel through Hotels.com?
There are lots of reasons to book your Upstate South Carolina trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.