Hotels in South Main

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Check prices for these dates

Tonight
Dec 24 - Dec 25
Tomorrow
Dec 25 - Dec 26
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Where to stay in South Main?

Premium bedding, pillowtop beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1198)
The price is CNY624
CNY731 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Wyndham Houston near NRG Park/Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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When is the best time to visit South Main?

Our prices for hotels in South Main are cheapest in February
Price trends for hotels in South Main
Pricing is based on two traveler single night rates
View properties in December
Currently viewing crowd sizes and weather for December.
Typical weather for Houston
December
Low crowds
High 18°C / low 10°C. Sunny most days.
View properties in December
18°
weather_sun
December, Low crowds, average high temperature 18 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
10°
17°
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January, Low crowds, average high temperature 17 degrees Celsius, average low temperature 8 degrees Celsius. Sunny most days.
8°
19°
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February, Low crowds, average high temperature 19 degrees Celsius, average low temperature 10 degrees Celsius. Cloudy most days.
10°
23°
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March, High crowds, average high temperature 23 degrees Celsius, average low temperature 14 degrees Celsius. Sunny most days.
14°
26°
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April, High crowds, average high temperature 26 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
17°
30°
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May, High crowds, average high temperature 30 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
33°
weather_sun
June, Moderate crowds, average high temperature 33 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
24°
34°
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July, High crowds, average high temperature 34 degrees Celsius, average low temperature 25 degrees Celsius. Sunny most days.
25°
34°
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August, Moderate crowds, average high temperature 34 degrees Celsius, average low temperature 26 degrees Celsius. Sunny most days.
26°
32°
weather_sun
September, Low crowds, average high temperature 32 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
28°
weather_sun
October, Moderate crowds, average high temperature 28 degrees Celsius, average low temperature 19 degrees Celsius. Sunny most days.
19°
22°
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November, Moderate crowds, average high temperature 22 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
13°
Monthly weather averages (˚C)

Check out reviews of South Main hotels guests love

The Whitehall Houston

The Whitehall Houston

10/10 Excellent
"The staff were very helpful and the place was beautiful. "
Ashley 2-night trip
Posted 2 days ago
The Whitehall Houston

Frequently asked questions

Is South Main expensive to stay in?
You can find great hotels from CNY460 in South Main to suit a range of budgets. To find the best low-cost hotel on Hotels.com that meets your needs, apply your search filters and then sort hotels by "Price: low to high".
How can I find discounted rates and deals for South Main hotels?
Discover great deals on hotels in South Main with Hotels.com. Sign up for free to unlock member only prices and start earning rewards. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on South Main hotels.
Can I receive a refund if I cancel my South Main hotel booking?
The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel your booking. Some South Main hotels require you to cancel more than 24 hours before check-in, so look at your booking beforehand. For extra peace of mind before you book, filter hotels by "Property cancellation options" and select "Fully refundable property".
What are some of the best pet-friendly hotels in South Main?
Traveling with your pet doesn't mean sacrificing a great hotel stay. In South Main, our travelers love:
What are some of the best South Main hotels for couples?
One of the best South Main hotels for couples is Wingate Houston near NRG Park/Medical Center. Wingate Houston near NRG Park/Medical Center is a popular hotel with an outdoor pool. Find more romantic South Main hotels by using the "Traveler experience" filter in your search and selecting "Adults only" or "Romantic".
What are some of the best South Main hotels with a pool?
Book a South Main hotel with a pool for some added relaxation or exercise on your trip. Wyndham Houston near NRG Park/Medical Center is a top-rated hotel with an outdoor pool, and an average guest score of 7.2 out of 10. This hotel also features a restaurant and a bar/lounge. Wingate Houston near NRG Park/Medical Center is another great hotel that features an outdoor pool, along with a free continental breakfast and a gym. For more South Main hotels with a pool, use the "Amenities" filter in your search and select "Pool" on Hotels.com.
Is it worth staying in South Main?
You're spoilt for choice with 63 hotels in the area so it's easy to find your perfect somewhere. Basing yourself in South Main makes it easy to explore Houston, including the neighborhoods of The Galleria and Texas Medical Center.
Which station is best for South Main?
The main station in South Main is Fannin South Station. If you're staying at a hotel in South Main, check out the nearest station so that you can get around and explore with ease.
Find out more about South Main

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