Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Santa Cruz on Hotels.com. These Santa Cruz hotels consistently deliver on quality, location and traveler experience. Last updated on .
Hotels in Santa Cruz
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Tonight
Sep 11 - Sep 12Tomorrow
Sep 12 - Sep 13This weekend
Sep 11 - Sep 13Next weekend
Sep 18 - Sep 20Where to stay in Santa Cruz?
1. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio HotelEquipetrol
CNY963
CNY963 total
Oct 3 - Oct 4
2. Ibis Santa Cruz DE LA Sierra
Ibis Santa Cruz DE LA SierraEquipetrol
CNY304
CNY304 total
Oct 2 - Oct 3
3. Hotel LP Equipetrol
Hotel LP EquipetrolEquipetrol
CNY264
CNY297 total
Sep 12 - Sep 13
4. Marriott Santa Cruz de la Sierra Hotel
Marriott Santa Cruz de la Sierra HotelSanta Cruz
CNY709
CNY709 total
Oct 9 - Oct 10
5. Camino Real Hotel
Camino Real HotelSanta Cruz
CNY1,108
CNY1,108 total
Oct 8 - Oct 9
6. Premium Suites Deluxe Aparthotel Equipetrol
Premium Suites Deluxe Aparthotel EquipetrolSanta Cruz
CNY309
CNY309 total
Sep 12 - Sep 13
9. Novotel Santa Cruz De La Sierra
Novotel Santa Cruz De La SierraSanta Cruz
CNY829
CNY829 total
Oct 1 - Oct 2
10. Delfines Collection Hotel By Mercure
Delfines Collection Hotel By MercureEquipetrol
CNY355
CNY355 total
Sep 12 - Sep 13
11. Swissôtel Santa Cruz De La Sierra
Swissôtel Santa Cruz De La SierraSanta Cruz
CNY880
CNY880 total
Oct 1 - Oct 2
15. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Hampton by Hilton Santa Cruz/Equipetrol, BoliviaSanta Cruz
CNY494
CNY494 total
Oct 9 - Oct 10
16. TRYP by Wyndham Santa Cruz
TRYP by Wyndham Santa CruzEquipetrol
CNY585
CNY585 total
Oct 7 - Oct 8
17. Hotel Las Américas
Hotel Las AméricasCentro Histórico
CNY175
CNY175 total
Sep 13 - Sep 14
18. Alfonsina Hotel Boutique by Inboccaluppo
Alfonsina Hotel Boutique by InboccaluppoEquipetrol
CNY723
CNY723 total
Sep 28 - Sep 29
20. Gran Hotel Santa Cruz
Gran Hotel Santa CruzCentro Histórico
CNY391
CNY391 total
Sep 12 - Sep 13
Get last-minute hotel deals in Santa Cruz and save more
Sign in to unlock great savings.
CNY419
per night
CNY838 total
Sign in for extra savings
We have 1 left at
Chairú Eco HotelCNY428
per night
CNY856 total
CNY1,453
per night
CNY2,906 total
Sign in for extra savings
CNY255
per night
CNY543 total
CNY472 off
Hotel LP EquipetrolCNY377
per night
CNY787 total
We have 3 left at
AMERICA APARTMENTSCNY299
per night
CNY598 total
We have 5 left at
Hotel Las AméricasCNY217
per night
CNY435 total
We have 5 left at
Apart Hotel Premium Suites Santa CruzCNY181
per night
CNY362 total
We have 6 left at
Alfonsina Hotel Boutique by InboccaluppoCNY899
per night
CNY1,797 total
CNY353
per night
CNY353 total
Sign in for extra savings
CNY1,082
per night
CNY1,082 total
Sign in for extra savings
We have 2 left at
Cosmopolitano Hotel BoutiqueCNY416
per night
CNY416 total
CNY873
per night
CNY873 total
Sign in for extra savings
CNY881
per night
CNY881 total
Sign in for extra savings
CNY451 off
Alfonsina Hotel Boutique by InboccaluppoCNY724
per night
CNY724 total
We have 7 left at
Hotel LP Santa Cruz CentroCNY198
per night
CNY232 total
We have 5 left at
AMERICA APARTMENTSCNY230
per night
CNY230 total
We have 5 left at
Hotel Las AméricasCNY175
per night
CNY175 total
Check out pet-friendly hotels in Santa Cruz
CNY304
CNY304 total
Oct 2 - Oct 3
CNY264
CNY297 total
Sep 12 - Sep 13
CNY198
CNY232 total
Oct 8 - Oct 9
CNY385
CNY385 total
Sep 15 - Sep 16
Gran Hotel Santa Cruz
Gran Hotel Santa CruzCentro Histórico
CNY391
CNY391 total
Sep 12 - Sep 13
Gran Hotel Mediterráneo
Gran Hotel MediterráneoCentro Histórico
CNY222
CNY222 total
Sep 12 - Sep 13
You can also stay at hotels with a pool in Santa Cruz
CNY309
CNY309 total
Sep 12 - Sep 13
CNY829
CNY829 total
Oct 1 - Oct 2
CNY723
CNY723 total
Sep 28 - Sep 29
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio HotelEquipetrol
CNY963
CNY963 total
Oct 3 - Oct 4
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all propertiesGo beyond your typical stay in Santa Cruz
Pet friendly
Family friendly
Our prices for hotels in Santa Cruz are cheapest in February
Our prices for hotels in Santa Cruz are cheapest in February
Price trends for hotels in Santa Cruz
Pricing is based on two traveler single night rates
Top neighborhoods in Santa Cruz
Top landmarks in Santa Cruz
Plaza 24 de Septiembre
8.8/10 (164 reviews)
If you're planning a bit of sightseeing during your trip, head to Plaza 24 de Septiembre— just one of the monuments in central Santa Cruz.
San Lorenzo Cathedral
9.0/10 (84 reviews)
San Lorenzo Cathedral is in the heart of Santa Cruz, so why not stop by during your stay.
Ventura Mall
9.0/10 (183 reviews)
If you like shopping, take time out to go to Ventura Mall when in Santa Cruz.
Guembe Biocenter
8.8/10 (60 reviews)
Ready for an education in local botany? Guembe Biocenter should make your list of places to visit, located 1.2 mi (2 km) from central Colinas del Urubo. Want to stretch your legs some more? Head to Arenal Park, located nearby.
Santa Cruz Zoo
8.4/10 (53 reviews)
It's feeding time at the zoo! If you want to be reminded of some of the great animals our world is home to, you might want to pay a trip to Santa Cruz Zoo, located 1.7 mi (2.8 km) from central Santa Cruz. If you have fun at Santa Cruz Zoo, you'll love Guembe Biocenter and Artecampo, both located nearby.
Ramon Tahuichi Aguilera Stadium
8.4/10 (18 reviews)
You can catch an event at Ramon Tahuichi Aguilera Stadium, located 0.8 mi (1.3 km) from central Santa Cruz.
Blacutt Square
8.2/10 (19 reviews)
You might want to get your camera out and head to Blacutt Square— just one of the landmarks located 0.7 mi (1.1 km) from central Santa Cruz.
Cine Center
8.0/10 (53 reviews)
Cine Center is 1 mi (1.6 km) from central Santa Cruz, why not stop by during your stay. If you enjoy the show and want to see another, Casa Municipal de Cultura Raúl Otero Reiche isn't far.
Learn more about Santa Cruz
Santa Cruz is applauded for its cultural attractions such as Ethno-folkloric Museum and Cine Center.
See all hotels in Santa Cruz
Check out reviews of Santa Cruz hotels guests love
Hotel Cortez
10/10 Excellent
"Awesome Hotel"
Sun Hotel
10/10 Excellent
"Very nice place to stay. Close to the airport with shuttle to the hotel."
Ibis Santa Cruz DE LA Sierra
10/10 Excellent
"N. A."
TRYP by Wyndham Santa Cruz
10/10 Excellent
"We had a great stay here. The rooms were clean and comfortable. Will return!"
Camino Real Hotel
10/10 Excellent
"The food is excellent quality and delicious! Friendly staff"
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
10/10 Excellent
"The room was very clean and the breakfast was fantastic. Overall it was a great experience."
Hotel Las Américas
10/10 Excellent
"DELICIOSO EL DESAYUNO"
Novotel Santa Cruz De La Sierra
10/10 Excellent
"All around good price and location"
HOTEL OSHO
10/10 Excellent
"Good"