Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Santa Cruz on Hotels.com. These Santa Cruz hotels consistently deliver on comfort, location and traveler experience. Last updated on .
Hotels in Santa Cruz
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Aug 14 - Aug 15Tomorrow
Aug 15 - Aug 16This weekend
Aug 14 - Aug 16Next weekend
Aug 21 - Aug 23Where to stay in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio HotelSanta Cruz
CNY854
CNY854 total
Aug 23 - Aug 24
Ibis Santa Cruz DE LA Sierra
Ibis Santa Cruz DE LA SierraSanta Cruz
CNY229
CNY229 total
Aug 28 - Aug 29
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Hampton by Hilton Santa Cruz/Equipetrol, BoliviaSanta Cruz
CNY496
CNY496 total
Aug 27 - Aug 28
Marriott Santa Cruz de la Sierra Hotel
Marriott Santa Cruz de la Sierra HotelSanta Cruz
CNY713
CNY713 total
Sep 11 - Sep 12
Hotel LP Equipetrol
Hotel LP EquipetrolSanta Cruz
CNY232
CNY266 total
Aug 15 - Aug 16
Premium Suites Deluxe Aparthotel Equipetrol
Premium Suites Deluxe Aparthotel EquipetrolSanta Cruz
CNY310
CNY310 total
Aug 26 - Aug 27
TRYP by Wyndham Santa Cruz
TRYP by Wyndham Santa CruzSanta Cruz
CNY662
CNY662 total
Aug 26 - Aug 27
Novotel Santa Cruz De La Sierra
Novotel Santa Cruz De La SierraSanta Cruz
CNY834
CNY834 total
Sep 1 - Sep 2
Swissôtel Santa Cruz De La Sierra
Swissôtel Santa Cruz De La SierraSanta Cruz
CNY998
CNY998 total
Aug 28 - Aug 29
Alfonsina Hotel Boutique by Inboccaluppo
Alfonsina Hotel Boutique by InboccaluppoSanta Cruz
CNY727
CNY727 total
Aug 27 - Aug 28
Cosmopolitano Hotel Boutique
Cosmopolitano Hotel BoutiqueSanta Cruz
CNY374
CNY374 total
Aug 18 - Aug 19
Equipetrol Suites Apart Hotel
Equipetrol Suites Apart HotelSanta Cruz
CNY335
CNY335 total
Aug 15 - Aug 16
Delfines Collection Hotel By Mercure
Delfines Collection Hotel By MercureSanta Cruz
CNY322
CNY322 total
Aug 28 - Aug 29
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CNY254
per night
CNY507 total
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CNY1,155
per night
CNY2,309 total
Sign in for extra savings
CNY464 off
Hotel LP EquipetrolCNY232
per night
CNY498 total
CNY826
per night
CNY1,651 total
Sign in for extra savings
We have 8 left at
TRYP by Wyndham Santa CruzCNY625
per night
CNY1,250 total
CNY907 off
Alfonsina Hotel Boutique by InboccaluppoCNY727
per night
CNY1,454 total
We have 4 left at
Hotel LP Santa Cruz CentroCNY246
per night
CNY525 total
We have 1 left at
Cosmopolitano Hotel BoutiqueCNY641
per night
CNY1,281 total
We have 5 left at
Apart Hotel Premium Suites Santa CruzCNY182
per night
CNY364 total
We have 5 left at
Hotel Las AméricasCNY176
per night
CNY352 total
CNY240
per night
CNY240 total
Sign in for extra savings
We have 2 left at
Cosmopolitano Hotel BoutiqueCNY458
per night
CNY458 total
We have 7 left at
Chairú Eco HotelCNY379
per night
CNY379 total
CNY1,124
per night
CNY1,124 total
Sign in for extra savings
CNY453 off
Alfonsina Hotel Boutique by InboccaluppoCNY727
per night
CNY727 total
CNY232 off
Hotel LP EquipetrolCNY232
per night
CNY266 total
CNY74 off
TRYP by Wyndham Santa CruzCNY662
per night
CNY662 total
CNY826
per night
CNY826 total
Sign in for extra savings
CNY266 off
Hotel LP Santa Cruz CentroCNY246
per night
CNY279 total
We have 6 left at
Apart Hotel Premium Suites Santa CruzCNY182
per night
CNY182 total
Check out pet-friendly hotels in Santa Cruz
CNY229
CNY229 total
Aug 28 - Aug 29
CNY232
CNY266 total
Aug 15 - Aug 16
CNY374
CNY374 total
Aug 18 - Aug 19
CNY246
CNY279 total
Sep 13 - Sep 14
CNY335
CNY335 total
Aug 15 - Aug 16
CNY998
CNY998 total
Aug 28 - Aug 29
You can also stay at hotels with a pool in Santa Cruz
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio HotelSanta Cruz
CNY854
CNY854 total
Aug 23 - Aug 24
CNY713
CNY713 total
Sep 11 - Sep 12
CNY310
CNY310 total
Aug 26 - Aug 27
CNY662
CNY662 total
Aug 26 - Aug 27
CNY834
CNY834 total
Sep 1 - Sep 2
CNY727
CNY727 total
Aug 27 - Aug 28
CNY374
CNY374 total
Aug 18 - Aug 19
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all propertiesGo beyond your typical stay in Santa Cruz
Pet friendly
Family friendly
Our prices for hotels in Santa Cruz are cheapest in February
Our prices for hotels in Santa Cruz are cheapest in February
Price trends for hotels in Santa Cruz
Pricing is based on two traveler single night rates
Top neighborhoods in Santa Cruz
Top landmarks in Santa Cruz
Plaza 24 de Septiembre
8.8/10 (164 reviews)
If you're planning a bit of sightseeing during your trip, head to Plaza 24 de Septiembre— just one of the monuments in central Santa Cruz.
San Lorenzo Cathedral
9.0/10 (84 reviews)
San Lorenzo Cathedral is in the heart of Santa Cruz, so why not stop by during your stay.
Ventura Mall
9.0/10 (183 reviews)
If you like shopping, take time out to go to Ventura Mall when in Santa Cruz.
Guembe Biocenter
8.8/10 (60 reviews)
Ready for an education in local botany? Guembe Biocenter should make your list of places to visit, located 1.2 mi (2 km) from central Colinas del Urubo. Want to stretch your legs some more? Head to Arenal Park, located nearby.
Santa Cruz Zoo
8.4/10 (53 reviews)
It's feeding time at the zoo! If you want to be reminded of some of the great animals our world is home to, you might want to pay a trip to Santa Cruz Zoo, located 1.7 mi (2.8 km) from central Santa Cruz. If you have fun at Santa Cruz Zoo, you'll love Guembe Biocenter and Artecampo, both located nearby.
Cine Center
8.0/10 (53 reviews)
Cine Center is 1 mi (1.6 km) from central Santa Cruz, why not stop by during your stay. If you enjoy the show and want to see another, Casa Municipal de Cultura Raúl Otero Reiche isn't far.
Ramon Tahuichi Aguilera Stadium
8.4/10 (18 reviews)
You can catch an event at Ramon Tahuichi Aguilera Stadium, located 0.8 mi (1.3 km) from central Santa Cruz.
Lomas de Arena Regional Park
8.4/10 (28 reviews)
Commune with nature and explore Lomas de Arena Regional Park located 10.7 mi (17.1 km) from central Santa Cruz.
Learn more about Santa Cruz
Santa Cruz is applauded for its cultural attractions such as Cine Center and Ethno-folkloric Museum.
See all hotels in Santa Cruz
Check out reviews of Santa Cruz hotels guests love
Ibis Santa Cruz DE LA Sierra
10/10 Excellent
"Excelente espacio Muy amable el personal"
Marriott Santa Cruz de la Sierra Hotel
10/10 Excellent
"I have come across the best Marriott experience on earth. The customer service was inexplicable. It was incredible. I was treated like a President. The staff were friendly, professional, and most welcoming. I seriously cannot find words to describe the experience. I would like to go back to Santa Cruz, Bolivia only because of the awesome experience at the Marriott Santa Cruz de la Sierra. I have stayed at numerous Marriott hotels in the US and in different countries; I have never felt like this before. The experience has never gone so deep. I have had by far, the best experience with any Marriott hotels. In addition, the hotel was so perfectly kept. It was a Wow!"
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
10/10 Excellent
"Como siempre el Mejor nivel para estancias en Santa Cruz"
Sun Hotel
10/10 Excellent
"El mejor servicio cerca del aeropuerto de Viru Viru"
Premium Suites Deluxe Aparthotel Equipetrol
10/10 Excellent
"great place to stay!"
Hotel LP Equipetrol
8/10 Good
"El cuarto agradable, pero faltó servicio de ayuda para subir y bajar maletas, también servicio adecuado de taxi para moverse en Santa Cruz"
Alfonsina Hotel Boutique by Inboccaluppo
10/10 Excellent
"Good hotel. Very contemporary; buffet breakfast included. We walked to the old part of the city/cathedral - probably about 40 minutes walk but can stop for a coffee along the way! Restaurant and bar in hotel. Hotel also close to many other restaurants/bars"
Delfines Collection Hotel By Mercure
10/10 Excellent
"Great location, nice and quiet neighborhood."
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
10/10 Excellent
"Staff is very patient and professional. Property is very clean and well maintained."