Photo by Emilia Cotto

Hotels in San Mateo Milpas Altas

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Where to stay in San Mateo Milpas Altas?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in San Mateo Milpas Altas on Hotels.com. These San Mateo Milpas Altas hotels consistently deliver on quality, location and traveler experience. Last updated on September 23, 2026.

A wooden deck with a hot tub and a bench, overlooking a mountainous landscape.

A wooden staircase leading to a second floor, a small wooden table, and a white sink with a stone backsplash.

A bedroom with two beds, a hanging chair, and a large window with a view of greenery.

A modern house with a sloped roof, surrounded by dense greenery.

1. Cabañas Casa Realeza

Antigua Guatemala

CNY1,956

CNY2,386 total

includes taxes & fees

Sep 24 - Sep 25

A balcony with a table set for breakfast, overlooking a mountainous landscape.

A hotel room with two beds, a green wall, and a painting.

A hallway with a dark wooden door, a tiled floor, and a potted plant with flowers.

A room with a bed, a flat-screen TV mounted on the wall, a small wooden table with a vase of flowers, and a window with curtains.

2. Hotel El Tambor OASIS Antigua Guatemala

Antigua Guatemala

CNY335

CNY409 total

includes taxes & fees

Sep 24 - Sep 25

A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

A nighttime view of a pool area with a reflection of trees and a building.

A bathroom with a bathtub, a shower, and a toilet. There is a small table and chairs outside the bathroom.

A covered outdoor area with lounge chairs and a stone wall.

3. Hotel Museo Spa Casa Santo Domingo

Barrio de La Concepción

CNY1,595

CNY2,027 total

includes taxes & fees

Sep 24 - Sep 25

A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

A white building with a staircase leading to a balcony, surrounded by potted plants and greenery.

A neatly arranged bedroom with a bed, bedside lamps, a bedside table with a plant, a painting on the wall, and a floor lamp.

A street view of El Carmen Hotel with traditional architecture, a cobblestone street, and a clear sky.

4. El Carmen Hotel

Historic Center

CNY497

CNY607 total

includes taxes & fees

Sep 27 - Sep 28

A cozy room with a round table, striped armchairs, and a potted plant.

A courtyard with a central fountain, surrounded by lush greenery and a traditional building with wooden beams and tiled roof.

A cozy living room with a stone wall, a fireplace, and a comfortable seating area with a sofa and chairs.

A courtyard with a covered patio, palm trees, and a variety of plants.

5. Hotel Camino Real Antigua

Historic Center

CNY1,266

CNY1,712 total

includes taxes & fees

Sep 27 - Sep 28

A bedroom with a four-poster bed, two armchairs, a desk, and a nightstand.

A spacious bedroom with a large bed, a sitting area with chairs, a desk, and a fireplace.

A courtyard with a fountain, stone pathway, and seating area surrounded by greenery.

A spacious living room with a fireplace, leather furniture, and stone walls.

6. El Convento Boutique Hotel

Historic Center

CNY1,608

CNY2,062 total

includes taxes & fees

Sep 24 - Sep 25

A modern, triangular wooden structure with a glass entrance, surrounded by lush greenery.

A spacious living area with a high ceiling, a glass dining table, and comfortable seating.

A pathway leading to a wooden deck with a view of a valley.

A room with two beds aligned in the center, wooden beams, and a large window at the end of the room.

7. Santo Cielo by Casa Santo Domingo

Antigua Guatemala

CNY1,423

CNY1,818 total

includes taxes & fees

Sep 24 - Sep 25

A restaurant with a brick wall, wine racks, and tables set for dining.

A bedroom with a bed, a bedside table, a lamp, a window with curtains, and a view of greenery outside.

A building with a balcony, potted plants, and a brick wall.

A bathroom with a large mirror, wall-mounted lights, and a wooden ceiling.

8. Los Pasos Boutique Hotel & Spa

Antigua Guatemala

CNY877

CNY1,110 total

includes taxes & fees

Sep 28 - Sep 29

A garden pathway leading to a building with a green lawn and a clear blue sky.

An outdoor dining area with round tables set for a formal event, surrounded by white chairs and covered by a wooden pergola.

An outdoor covered area with a stone floor, wooden beams, and a fountain.

A spa room with wooden floors, two massage tables with towels, a white bathtub, and a decorative wall piece.

9. Hotel Soleil La Antigua

Antigua Guatemala

CNY740

CNY903 total

includes taxes & fees

Sep 24 - Sep 25

A garden with a pergola, potted plants, and a chair.

A courtyard with a large planter filled with flowers, a covered patio area with arches, and a view of a mountain in the background.

A bedroom with a wooden bed, a fireplace, a chair, and a vase with a flower.

A cozy living room with a wooden table, a sofa, and a large window with plants.

10. Casa Santa Rosa Hotel Boutique

Historic Center

CNY783

CNY955 total

includes taxes & fees

Sep 27 - Sep 28

A corridor with a bench, potted plants, and a hanging light fixture.

A narrow, tiled corridor with potted plants on both sides, leading to a brightly lit area with hanging plants.

A compact living space with a dining area, kitchen, and a large window.

A corridor with wooden beams on the ceiling, a floral arrangement on a table, and potted plants along the walls.

11. Nico Hotel

Antigua Guatemala

CNY410

CNY500 total

includes taxes & fees

Sep 24 - Sep 25

A covered outdoor area with stone flooring, potted plants, and a wooden pergola.

A spacious room with a large bed, a fireplace, and a view of a courtyard.

A courtyard with a swimming pool, stone walls, and a white building with a balcony.

A courtyard with a stone pathway, a fountain, and a building with a white facade and blue accents.

12. San Rafael Hotel

Historic Center

CNY1,206

CNY1,491 total

includes taxes & fees

Oct 6 - Oct 7

A lush garden with a rock waterfall, potted plants, and a well-maintained lawn.

A lush garden with a variety of plants and a brick wall with climbing vines.

A hallway with a mural, a chandelier, and a staircase leading to a dining area.

A patio with lounge chairs, a table, and potted plants.

13. Hotel Camelias Inn by AHS

Historic Center

CNY315

CNY384 total

includes taxes & fees

Sep 27 - Sep 28

A corner with two upholstered chairs, a small round table, and a potted plant.

A hotel room with a bed, a nightstand, a lamp, and a wall with a textured pattern.

Two brown leather armchairs with tufted backs and wooden legs, a small round glass table, and a tiled floor.

A covered outdoor seating area with wicker furniture and hanging lights.

14. Ciel-Luxe Hotels

Historic Center

CNY568

CNY693 total

includes taxes & fees

Sep 24 - Sep 25

An outdoor seating area with tables and chairs, surrounded by a tree and string lights.

A dining area with a chandelier, a large tapestry, and a traditional wooden cabinet.

A stone pathway under a covered archway surrounded by lush greenery.

A room with two beds, wooden headboards, a chandelier, a window with curtains, and a mirror.

15. Casa Noble Hotel

Antigua Guatemala

CNY572

CNY698 total

includes taxes & fees

Sep 24 - Sep 25

A man in a swimming pool with a stone wall and a rock formation.

A stone-walled room with a glass door leading to a stone interior, a bathtub, and a shower area.

An indoor swimming pool with clear water, stone walls, and decorative lighting.

A multi-level atrium with a central staircase, wooden railings, and a series of hanging lights.

16. Le Suisse Spa

Santa Lucía Milpas Altas

CNY541

CNY661 total

includes taxes & fees

Oct 22 - Oct 23

A covered corridor with tiled flooring, potted plants, and a wooden bench.

A spacious indoor area with a wooden floor, large windows, and a high ceiling with a translucent canopy.

A restaurant with tables set for dining, large windows offering a view of greenery, and wooden ceiling beams.

A corridor with arches, tiled flooring, and potted plants.

17. Hotel Las Farolas

Antigua Guatemala

CNY603

CNY736 total

includes taxes & fees

Sep 28 - Sep 29

A rooftop terrace with outdoor seating, a fire feature, and a view of a mountain.

A spacious living room with a large window, a chandelier, and a statue.

A covered courtyard with stone flooring, columns, and potted plants.

A cozy living room with a fireplace, comfortable seating, and a view of the outdoors.

18. Las Cruces Boutique Hotel

Historic Center

CNY1,206

CNY1,471 total

includes taxes & fees

Sep 27 - Sep 28

A multi-level outdoor garden with potted plants and a wooden pergola structure.

A balcony with hanging ferns and potted plants, a brick wall, and a metal railing.

A room with two beds, a wooden ceiling, a desk with a chair, and a door.

A restaurant interior with wooden tables and stools, a bar area, and a visible kitchen.

19. Naif Boutique Hotel

Historic Center

CNY530

CNY647 total

includes taxes & fees

Sep 24 - Sep 25

A courtyard with stone walls, a fountain, and various plants and flowers.

A courtyard with a fountain, neatly trimmed hedges, and a building with arched windows and a tiled roof.

A courtyard with a fountain, potted plants, and a covered seating area with tables and chairs.

A well-lit courtyard with a stone pathway, surrounded by manicured lawns and a stone wall.

20. Hotel Posada de Don Rodrigo Antigua

Historic Center

CNY1,507

CNY1,839 total

includes taxes & fees

Sep 24 - Sep 25

View all properties

Go beyond your typical stay in San Mateo Milpas Altas

Pet friendly

Apartment

Apart hotel

Pool

Spa

Family friendly

Hot tub

Top landmarks in San Mateo Milpas Altas

La Azotea Cultural Center

La Azotea Cultural Center is in the heart of San Mateo Milpas Altas, so why not stop by during your stay. If you have fun at La Azotea Cultural Center, you'll love Hobbitenango and House of the Giants, both located nearby.

See properties

Learn more about San Mateo Milpas Altas

The region around San Mateo Milpas Altas is home to attractions such as La Azotea Cultural Center and Casa Santo Domingo Museum.

See all hotels in San Mateo Milpas Altas

A wooden viewing platform overlooking a mountainous landscape with a prominent volcano in the distance.

Check out reviews of San Mateo Milpas Altas hotels guests love

Barceló Guatemala City

10/10 Excellent

"Loved the 9th flower lounge. Very Clean Hotel. Great Staff. Going out of the Country and feeling cared for and taken care of. Super comfy Bed and pillows"

Wyndham Garden Guatemala City

10/10 Excellent

"Everything was excellent. Housekeeping, Breakfast staff, Bar Staff, Reception.......all of them."

Hotel Casa Bella

10/10 Excellent

"Room was nice. My room #8 was the only room on the 2nd floor and it had an outside patio where the staff served my breakfast each day. The staff is great. Location is central, but quiet."

El Convento Boutique Hotel

10/10 Excellent

"We stayed there just for a night. Wish we could have stayed for a couple more days to enjoy the amenities and the city."

El Carmen Hotel

10/10 Excellent

"Muy recomendable"

Good Hotel Guatemala City

10/10 Excellent

"Great location for getting to other places in Guatemala. Decent food nearby, though I didn't find a place with a desayuno típico."

Best Western Plus Hotel Stofella

8/10 Good

"En el desayuno Buffet, muy pocas opciones para degustar. No es muy amplio lo que ofrecen, Talvez deberían de ampliar el horario a las 11:00 AM."

Tikal Futura Hotel & Convention Center

10/10 Excellent

"Excelente servicio y las instalaciones muy bien conservadas."

The Westin Camino Real, Guatemala

10/10 Excellent

"Convenient location, friendly staff, cleanliness was great."

Frequently asked questions

How much does a hotel room cost in San Mateo Milpas Altas?

You can find top hotels in San Mateo Milpas Altas from CNY192 with options to suit your budget and needs. If you're looking for an affordable hotel in San Mateo Milpas Altas that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at San Mateo Milpas Altas hotels?

Discover great deals on San Mateo Milpas Altas hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on San Mateo Milpas Altas hotels.

Can I book San Mateo Milpas Altas hotels with free cancellation?

In order to book a refundable San Mateo Milpas Altas hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some popular hotels in central San Mateo Milpas Altas?

If you're looking for hotels in central San Mateo Milpas Altas, check out Hotel Camelias Inn by AHS and Hotel Casa Bella. Travelers love Hotel Camelias Inn by AHS for its location, as well as the spa services, rooftop terrace and proposal/romance packages this hotel offers. Hotel Casa Bella is another popular central bed & breakfast with a restaurant, a bar/lounge and a free cooked-to-order breakfast. Stay at one of these hotels for easy access to top sights like Antigua Guatemala Cathedral, Casa Santo Domingo Museum, and Central Park. Historic Center and Barrio de La Concepción are some of the most central neighborhoods for your San Mateo Milpas Altas vacation.

What hotels do travelers recommend in San Mateo Milpas Altas?

Guests like Hotel Museo Spa Casa Santo Domingo, Hotel Camino Real Antigua and El Carmen Hotel.

Can I book a refundable hotel in San Mateo Milpas Altas?

If you want the flexibility to change your travel plans to San Mateo Milpas Altas, most hotels provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.

Where can I stay in San Mateo Milpas Altas if I want a vacation rental instead of a traditional hotel?

If you want to find a good alternative to a hotel, review our selection of 6 vacation homes.

What will the weather in San Mateo Milpas Altas be like during my trip?

The warmest months in San Mateo Milpas Altas are usually April and March with an average temp of 67°F. January and December are the chilliest months when the average temp is 64°F. The rainiest months are September and June.

Why should I book my San Mateo Milpas Altas hotel with Hotels.com?

There are plenty of reasons to book your San Mateo Milpas Altas travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Keep exploring

Lodging