Hotels in Mesilla

Q: What hotels do travelers like in Mesilla?

Guests like Hotel Encanto de Las Cruces , Days Inn by Wyndham Las Cruces and La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain .

Where to?

Dates

April 2026

13

May 2026

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Where to stay in Mesilla?

Days Inn by Wyndham Las Cruces

Las Cruces

CNY392 total

includes taxes & fees

Apr 15 - Apr 16

Deluxe Room, 2 Double Beds, Non Smoking, Mountain View | Premium bedding, desk, iron/ironing board, free cribs/infant beds

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

Las Cruces

CNY484 total

includes taxes & fees

May 10 - May 11

Desk, blackout drapes, free cribs/infant beds, free WiFi

Super 8 by Wyndham Las Cruces University Area

Las Cruces

CNY387 total

includes taxes & fees

Apr 14 - Apr 15

Quality Inn & Suites Las Cruces - University Area

Las Cruces

CNY415 total

includes taxes & fees

May 12 - May 13

Hampton Inn & Suites Las Cruces I-10

Las Cruces

CNY804 total

includes taxes & fees

Apr 26 - Apr 27

Full-size fridge, microwave, toaster, cookware/dishes/utensils

Motel 9 Las Cruces

Las Cruces

CNY402 total

includes taxes & fees

Apr 17 - Apr 18

Ramada Hotel & Conference Center by Wyndham Las Cruces

Las Cruces

CNY643 total

includes taxes & fees

Apr 14 - Apr 15

Comfort Inn & Suites Las Cruces Mesilla

Las Cruces

CNY879 total

includes taxes & fees

Apr 26 - Apr 27

Econo Lodge Las Cruces University Area

Las Cruces

CNY461 total

includes taxes & fees

May 13 - May 14

Drury Inn & Suites Las Cruces

Las Cruces

CNY838 total

includes taxes & fees

Apr 26 - Apr 27

Big Chile Inn & Suites

Las Cruces

CNY491 total

includes taxes & fees

May 12 - May 13

La Quinta Inn by Wyndham Las Cruces Mesilla Valley

Las Cruces

CNY340 total

includes taxes & fees

Apr 16 - Apr 17

Best Western Mission Inn

Las Cruces

CNY679 total

includes taxes & fees

Apr 15 - Apr 16

Courtyard by Marriott Las Cruces at NMSU

Las Cruces

CNY1,055 total

includes taxes & fees

Apr 19 - Apr 20

Suite, 2 Double Beds | Down comforters, in-room safe, desk, laptop workspace

Springhill Suites By Marriott Las Cruces

Las Cruces

CNY846 total

includes taxes & fees

Apr 26 - Apr 27

Holiday Inn Express Hotel and Suites Las Cruces by IHG

Las Cruces

CNY897 total

includes taxes & fees

Apr 26 - Apr 27

Extended Stay America Select Suites - Las Cruces

Las Cruces

CNY470 total

includes taxes & fees

Apr 14 - Apr 15

Las Cruces Home w/ Fenced Yard: Recently Remodeled

Las Cruces

CNY1,746 total

includes taxes & fees

Apr 23 - Apr 24

Sleep Inn University

Las Cruces

CNY470 total

includes taxes & fees

May 10 - May 11

Century 21 Motel

Las Cruces

CNY541 total

includes taxes & fees

Apr 14 - Apr 15

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Go beyond your typical stay in Mesilla

Family friendly

Pool

Top landmarks in Mesilla

Mesillia Plaza

This adobe-lined plaza marks where Mexico sold land to the US in the Gadsden Purchase of 1854. Visit during fall festivals for authentic Mexican cuisine and thousands of luminarias.

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Fountain Theater

Experience film history at New Mexico's oldest continuously operating movie theater, dating back to 1905. Grab fresh popcorn and enjoy indie films while surrounded by historic murals of Mesilla.

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Learn more about Mesilla

Centuries-old adobe buildings frame the historic plaza, where the Confederate Territory of Arizona once claimed its brief capital. Duck into La Posta de Mesilla, a former stagecoach stop now serving chile rellenos that locals defend with patriotic fervor. The Fountain Theatre screens independent films in what might be the oldest movie house in the Southwest. Browse galleries where artists capture desert light in ways that make you understand why Georgia O'Keeffe never left. The Mesilla Plaza, a National Historic Landmark, hosts festivals where the smell of roasting green chiles mingles with mariachi music. Las Cruces sits just next door with its Museum of Nature & Science when you've had your fill of history.

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Check out reviews of Mesilla hotels guests love

Ramada Hotel & Conference Center by Wyndham Las Cruces

10/10 Excellent

"Bed was super comfortable and property was beautifully constructed. Staff was very friendly. Will definitely be returning often. "

Hampton Inn & Suites Las Cruces I-25

4/10 Poor

"I was assigned a handicap room and was told that was all that was available. When asked about cancellation policy I was told that since the booking was through a third party a cancellation was not possible. Basically we were held hostage in a location that we were not very happy with. I did not reserve a handicap room. I made the reservation well in advance of the stay. Hampton staff only cleans the room every other day??? I stayed two nights, so in reality the room was cleaned after departure, something done regardless. A very small sign on the sink details the room is only cleaned every other day. Staff did not advise this at check in. The room had a musky, moldy, odor. The climate in this area is very dry and would not attribute to the odor. The business office was an open area with a small printer on an unsteady table, the cord outstretched tightly. Very unimpressive unprofessional look. The pantry, where items can be purchased by guests was merely a wire cart with a few items on the shelves. There was no regular candy or chips. There were few drink choices in an unimpressive cooler. The staff was friendly. The issue here is not the staff. It’s the management and their apparent short cutting amenities and over booking stays. We have stayed in other Hampton locations and they where very agreeable. However, this particular location and its issues have guided us to the make the decision not to stay at any Hampton properties in the future. "

Frequently asked questions

How much does a hotel room cost in Mesilla?

You can discover great hotels in Mesilla from CNY340 with properties to suit all budgets and needs. If you're looking for an affordable hotel in Mesilla that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Mesilla hotels?

Discover great deals on Mesilla hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on Mesilla hotels.

Can I book Mesilla hotels with free cancellation?

In order to book a refundable Mesilla hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some popular hotels in central Mesilla?

If you're looking for hotels in central Mesilla, check out La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain and Drury Inn & Suites Las Cruces. Travelers love La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain for its location, as well as the outdoor pool, free continental breakfast and free parking this hotel offers. Drury Inn & Suites Las Cruces is another popular central hotel with an indoor pool, a hot tub and a free buffet breakfast. Picacho Hills is a central neighborhood for your Mesilla vacation.

What hotels do travelers like in Mesilla?

Guests like Hotel Encanto de Las Cruces, Days Inn by Wyndham Las Cruces and La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain.

Can I book a refundable hotel in Mesilla?

If you want the flexibility to change your travel plans to Mesilla, most accommodations offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Mesilla if I want a vacation rental instead of a traditional hotel?

If you're looking for a good alternative to a hotel, review our selection of 8 vacation homes.

What will the weather in Mesilla be like during my trip?

The warmest months in Mesilla are usually June and July with an average temp of 82°F. January and December are the chilliest months when the average temp is 48°F. The rainiest months are August and September.

Why should I book my Mesilla accommodation with Hotels.com?

There are plenty of reasons to book your Mesilla travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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