Photo by Alice Burghart

Hotels in Cape Girardeau

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Cape Girardeau?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Check out pet-friendly hotels in Cape Girardeau

You may also like hotels with pools in Cape Girardeau

You can also stay at family-friendly hotels in Cape Girardeau

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our prices for Cape Girardeau are cheapest in December

See average prices and weather for all months
Price trends for hotels in Cape Girardeau
Pricing is based on two traveler single night rates
View properties in November
Currently viewing crowd sizes and weather for November.
Weather forecast for Cape Girardeau
November
Moderate crowds
High 13°C / low 4°C. Partly sunny.
View properties in November
13°
weather_partly_sunny
November, Moderate crowds, average high temperature 13 degrees Celsius, average low temperature 4 degrees Celsius. Partly sunny.
weather_partly_sunny
December, Low crowds, average high temperature 9 degrees Celsius, average low temperature 1 degrees Celsius. Partly sunny.
weather_partly_sunny
January, Low crowds, average high temperature 6 degrees Celsius, average low temperature -2 degrees Celsius. Partly sunny.
-2°
weather_partly_sunny
February, Low crowds, average high temperature 8 degrees Celsius, average low temperature -1 degrees Celsius. Partly sunny.
-1°
14°
weather_sun
March, High crowds, average high temperature 14 degrees Celsius, average low temperature 5 degrees Celsius. Sunny most days.
19°
weather_sun
April, High crowds, average high temperature 19 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
25°
weather_sun
May, High crowds, average high temperature 25 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
15°
30°
weather_sun
June, Moderate crowds, average high temperature 30 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
20°
32°
weather_sun
July, Moderate crowds, average high temperature 32 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
31°
weather_sun
August, Moderate crowds, average high temperature 31 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
20°
28°
weather_sun
September, Low crowds, average high temperature 28 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
17°
21°
weather_sun
October, High crowds, average high temperature 21 degrees Celsius, average low temperature 11 degrees Celsius. Sunny most days.
11°
Monthly weather averages (˚C)

Top landmarks in Cape Girardeau

Learn more about Cape Girardeau

Hugging the Mississippi River, this college town reveals its history through vibrant floodwall murals that transform concrete into an outdoor gallery. Southeast Missouri State University brings youthful energy to streets lined with locally-owned shops and cafes. The River Campus hosts performances in a former seminary with river views. Explore the Cape Girardeau Conservation Nature Center or paddle the Mississippi. Trail of Tears State Park offers hiking paths with panoramic vistas that explain why settlers chose this dramatic spot. The Cape Riverfront Market buzzes with farmers and artisans, while the historic downtown invites exploration with red-brick buildings housing quirky boutiques and restaurants serving hearty Midwestern fare with surprising sophistication.

Beautiful city by the Mississippi River
Photo by Alice Burghart
Open Photo by Alice Burghart

Check out reviews of Cape Girardeau hotels guests love

Frequently asked questions

What hotels do travelers recommend in Cape Girardeau?
Can I book a refundable hotel in Cape Girardeau?
If you need the flexibility to change your travel plans to Cape Girardeau, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in Cape Girardeau if I'm looking for an affordable accommodation?
Pear Tree Inn Cape Girardeau West, Pear Tree Inn Cape Girardeau Near the Medical Center and Tru By Hilton Cape Girardeau are a few accommodations you might want to consider that'll save you money.
Where can I stay in Cape Girardeau if I want a vacation rental instead of a hotel?
If you want a good alternative to a hotel, look over our selection of 22 vacation homes. In addition, you can choose from 14 apartments.
What will the weather in Cape Girardeau be like during my vacation?
July and August are typically the warmest months in Cape Girardeau when the average temp is 76°F. January and February are the coldest months when the average temperature is 40°F. April and March are the months with the most rain.
Why should I book my Cape Girardeau hotel through Hotels.com?
There are lots of reasons to book your Cape Girardeau trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Keep exploring