Hotels in South Main
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Where to stay in South Main?

Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,002 reviews)
The price is CNY545
CNY638 total
includes taxes & fees
Apr 7 - Apr 8

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,263 reviews)
The price is CNY653
CNY764 total
includes taxes & fees
Apr 12 - Apr 13

Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,000 reviews)
The price is CNY684
CNY801 total
includes taxes & fees
Mar 29 - Mar 30

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
The price is CNY469
CNY549 total
includes taxes & fees
Apr 26 - Apr 27

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (844 reviews)
The price is CNY538
CNY630 total
includes taxes & fees
Apr 8 - Apr 9

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd32 km from South Main
9.2 out of 10, Wonderful, (1,000 reviews)
The price is CNY547
CNY629 total
includes taxes & fees
Apr 2 - Apr 3

Sonesta Simply Suites Houston – NASA Clear Lake
Sonesta Simply Suites Houston – NASA Clear Lake31.8 km from South Main
8.0 out of 10, Very Good, (1,001 reviews)
The price is CNY380
CNY444 total
includes taxes & fees
Mar 29 - Mar 30

Studio 6 Deer Park, TX
Studio 6 Deer Park, TX28.7 km from South Main
9.4 out of 10, Exceptional, (409 reviews)
The price is CNY480
CNY561 total
includes taxes & fees
Apr 4 - Apr 5

GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown28.8 km from South Main
8.6 out of 10, Excellent, (668 reviews)
The price is CNY373
CNY429 total
includes taxes & fees
Mar 29 - Mar 30

Hampton Inn & Suites Houston/Clear Lake-Nasa Area
Hampton Inn & Suites Houston/Clear Lake-Nasa Area30.9 km from South Main
8.4 out of 10, Very Good, (1,000 reviews)
The price is CNY564
CNY660 total
includes taxes & fees
Apr 8 - Apr 9

Platinum Inn & Suites Webster
Platinum Inn & Suites Webster30.8 km from South Main
7.8 out of 10, Good, (1,003 reviews)
The price is CNY528
CNY618 total
includes taxes & fees
Apr 19 - Apr 20

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,002 reviews)
The price is CNY608
CNY712 total
includes taxes & fees
Apr 26 - Apr 27

Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
The price is CNY605
CNY708 total
includes taxes & fees
Apr 8 - Apr 9

Home2 Suites by Hilton Houston Pasadena
Home2 Suites by Hilton Houston Pasadena24.3 km from South Main
9.4 out of 10, Exceptional, (847 reviews)
The price is CNY670
CNY783 total
includes taxes & fees
Apr 5 - Apr 6

Hotel Royale
Hotel Royale20.9 km from South Main
9.4 out of 10, Exceptional, (21 reviews)
The price is CNY559
CNY654 total
includes taxes & fees
Apr 1 - Apr 2

La Quinta Inn & Suites by Wyndham Houston Channelview
La Quinta Inn & Suites by Wyndham Houston ChannelviewNortheast Houston, 28.6 km from South Main
8.6 out of 10, Excellent, (887 reviews)
The price is CNY618
CNY724 total
includes taxes & fees
Apr 23 - Apr 24

Hampton Inn Houston I-10 East
Hampton Inn Houston I-10 East20.4 km from South Main
8.8 out of 10, Excellent, (575 reviews)
The price is CNY431
CNY504 total
includes taxes & fees
Apr 23 - Apr 24

Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (160 reviews)
The price is CNY697
CNY840 total
includes taxes & fees
Mar 29 - Mar 30

Fairfield Inn & Suites by Marriott Houston Hobby Airport.
Fairfield Inn & Suites by Marriott Houston Hobby Airport.Southeast Houston, 15.3 km from South Main
7.6 out of 10, Good, (1,006 reviews)
The price is CNY462
CNY541 total
includes taxes & fees
Mar 29 - Mar 30

Best Western Plus Hobby Airport Inn & Suites
Best Western Plus Hobby Airport Inn & Suites15.3 km from South Main
8.8 out of 10, Excellent, (1,473 reviews)
The price is CNY559
CNY654 total
includes taxes & fees
Apr 6 - Apr 7
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Wingate Houston near NRG Park/Medical Center | 6.6 1,002 reviews | View | ||||||
![]() Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View | ||||||
![]() Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,000 reviews | View | ||||||
![]() Candlewood Suites Houston Medical Center by IHG | 7.4 Good 844 reviews | View | ||||||
![]() Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,263 reviews | View |
Check out reviews of South Main hotels guests love

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
10/10 Excellent
Frequently asked questions
Find out more about South Main
Keep exploring
- Cottages in Willis
- Cheap Hotels in Houston
- Hotels with Kitchens in Surfside Beach
- Family Hotels in Sugar Land
- Motels in Pasadena
- Family Hotels in Crystal Beach
- Luxury Hotels near CityCentre
- Family Hotels in Cypress
- Theater District Hotels
- Pet-Friendly Hotels in Silk Stocking Historic District
- Hotels near Greenway Plaza Heliport
- Hotels with a Pool in Bay City
- Cloverleaf Hotels
- Hotels with Parking in Alvin
- Hotels near Houston Natural Science Museum
- Hotels with Kitchens in La Porte
- Cheap Hotels near CityCentre
- Family Hotels in Lake Jackson
- Hotels with Parking in Bay City
- Family Hotels near Buffalo Bayou Park
- Hotels with a Pool in Pasadena
- Luxury Hotels in Lake Jackson
- Hotels with Kitchens in Spring
- Greater Heights Hotels
- Cottages in Lake Jackson
- Apartments in Conroe
- Hotels with a Pool in Memorial City
- Hotels near Shell Energy Stadium
- Hotels near Houston Fire Museum
- Cheap Hotels in Memorial
- Cottages in Terramar Beach
- Hotels with Parking in Rosenberg
- Hotels with a Gym in Waller
- Family Hotels in Katy
- Hotels with Kitchens in Jamaica Beach
- Boulevard Oaks Hotels
- Missouri City Hotels
- Luxury Hotels in Woodlands Town Center
- Apartments in Harwin Drive Shopping District
- Pet-Friendly Hotels in Addicks
- Hotels with a Pool in Surfside Beach
- Cheap Hotels in Baytown
- Hotels near Quitman/Near Northside Station
- Houston Hotels
- Willow Meadows/Willowbend Area Hotels
- Shopping Hotels near CityCentre
- Motels in Sugar Land Town Square
- Shady Acres Hotels
- Hotels near MD Anderson Cancer Center
- Cheap Hotels near Fort Travis Seashore Park
- Booth Hotels
- Family Hotels in Stafford
- Hotels near K1 Speed Houston
- Hotels with Parking in Atascocita
- Motels in Bay City
- Hotels with Parking in Katy
- Apartments in Porretto Beach
- Downtown Houston Hotels
- Hotels with Parking in East Downtown Houston
- Galena Park Hotels
- Greater Hobby Area Hotels
- Hotels with Parking in South Main
- Hotels with Parking in Sealy
- Family Hotels in Channelview
- Hotels with Free Breakfast near Surfside Beach
- Luxury Hotels near Buffalo Bayou Park
- Hotels near Baylor St. Luke's Medical Center-McNair Campus
- Hotels near Bell Station
- Hotels near Kelsey Seybold
- Hotels with Parking near Buffalo Bayou Park
- Hotels near Bayou Place
- Hotels with Parking in San Leon
- Hotels with a Gym in Northside
- Hotels near Justin P. Brindley Trail
- Hotels near Westchase Helipad
- Hotels with a Pool in Conroe
- Hotels near Lone Star Flight Museum
- Hotels near Sugar Lakes Family Practice
- Woodforest Hotels
- Luxury Hotels in Houston
- Apartments in Woodlands Town Center
- Family Hotels in Montgomery
- Hotels with a Gym in Memorial City
- Lgbtqia Welcoming Hotels near San Jacinto Battleground State Historic Site
- Hotels with Parking in Memorial City
- Friendswood Hotels
- Spring Branch West Hotels
- Cheap Hotels near Porretto Beach
- Hotels with Parking in Terramar Beach
- Golf Hotels in Galveston
- Hotels with a Pool in Rosenberg
- Hotels with Parking in Memorial
- Hotels with Parking in Brookshire
- Hotels with Parking in Freeport
- Family Hotels in Houston Convention District
- Hotels with Free Breakfast near Buffalo Bayou Park
- Hotels with Kitchens in Pasadena









































































