Hotels in La Mesa

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Tonight
Oct 10 - Oct 11
Tomorrow
Oct 11 - Oct 12
Next weekend
Oct 16 - Oct 18
In two weeks
Oct 23 - Oct 25

Where to stay in La Mesa?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in La Mesa on Hotels.com. These La Mesa hotels consistently deliver on quality, location and traveler experience. Last updated on .

A spacious lobby with leather sofas, a round coffee table with fruit, and a ceiling adorned with colorful hanging ornaments.
A hotel room with a large bed, a sofa, a nightstand with a lamp, and a vase of flowers.
A breakfast bar with a variety of fruits, a Hershey's chocolate bar, and a coffee machine.
A swimming pool with a wooden deck, lounge chairs, and a gated entrance.

1. Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
La Mesa
CNY959
CNY1,054 total
includes taxes & fees
Oct 18 - Oct 19
Best Western Plus La Mesa San Diego
A hotel room with a bed, a bedside table with a phone, and a nightstand.
A motel with a red-tiled roof, multiple balconies, and a sign indicating room number 6.
A hotel room with a large window, a poster on the wall, and a tiled floor.
A building with a '6' sign, surrounded by lush greenery and palm trees.

2. Motel 6 La Mesa, CA - San Diego

Motel 6 La Mesa, CA - San Diego
La Mesa
CNY669
CNY736 total
includes taxes & fees
Oct 14 - Oct 15
Motel 6 La Mesa, CA - San Diego
A building with a 'Lobby' and 'Vacancy' sign, surrounded by a variety of flowering plants.
A swimming pool with a metal ladder, a blue chair, and a white chair.
A hotel room with two beds, a chair, a desk, and a lamp.
A vending machine with snacks and a Coca-Cola machine.

3. Heritage Inn La Mesa

Heritage Inn La Mesa
La Mesa
CNY509
CNY561 total
includes taxes & fees
Oct 12 - Oct 13
Heritage Inn La Mesa
A modern hotel room with two beds, a balcony, and a desk.
A motel with a red-tiled roof, multiple balconies, and a parking area with several vehicles.
A motel with a prominent '6' sign, a parking lot with several cars, and a well-lit entrance.
A modern reception area with a digital screen, a small table with chairs, and a coffee machine.

4. Motel 6 La Mesa, CA

Motel 6 La Mesa, CA
La Mesa
CNY663
CNY729 total
includes taxes & fees
Oct 25 - Oct 26
Motel 6 La Mesa, CA
A spacious living room with a large arched window, a red sofa, a coffee table, and a chandelier.
A spacious living area with a red sofa, a coffee table with a fruit bowl, and a modern chandelier.
A hotel room with a bed, a desk, a chair, a TV, and a painting on the wall.
A swimming pool with lounge chairs and umbrellas, surrounded by a building with a white facade and a tree with lights.

5. Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
Mid-City
CNY722
CNY814 total
includes taxes & fees
Nov 1 - Nov 2
Lamplighter Inn & Suites at SDSU
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.
A hotel with a prominent bell tower, a covered entrance, and a well-lit facade.
A hotel with a swimming pool, outdoor seating, and palm trees.
A hotel room with two beds, a television, a desk, and a dresser.

6. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
Chula Vista
CNY694
CNY763 total
includes taxes & fees
Nov 1 - Nov 2
La Quinta Inn by Wyndham San Diego Chula Vista
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.
A snack and beverage vending area with a variety of snacks and Coca-Cola bottles.
A multi-story hotel with a parking lot, a landscaped area with palm trees, and a clear sky.
A hotel room with two beds, a desk, a lamp, and a window with curtains.

7. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
Chula Vista
CNY691
CNY761 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Inn Chula Vista San Diego South
A breakfast buffet area with a stone wall, a coffee station, and a fruit display.
A table with two gold-framed lamps and a vase of white flowers.
A modern hotel lobby with a fireplace, comfortable seating, and a large painting of a sunset.
An elevator area with stone walls and a potted plant.

8. Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
Kearny Mesa
CNY762
CNY875 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn San Diego-Kearny Mesa
A hotel with a stone facade, a covered entrance, and a sign reading "Springhill Suites Marriott".
A modern hotel lobby with a reception desk, seating area, and a bar.
A hotel room with a sofa, a wooden desk, a chair, a TV, and a tray table.
A modern kitchen with a wooden desk, a chair, a sink, and a coffee maker.

9. SpringHill Suites by Marriott San Diego Rancho Bernardo/Scripps Poway

SpringHill Suites by Marriott San Diego Rancho Bernardo/Scripps Poway
Miramar Ranch North
CNY878
CNY1,009 total
includes taxes & fees
Nov 1 - Nov 2
SpringHill Suites by Marriott San Diego Rancho Bernardo/Scripps Poway
A spacious lobby with a fireplace, wooden furniture, and a chandelier.
A hotel room with a bed, desk, chair, couch, and a television.
A hotel reception area with a counter, bar stools, a flat-screen TV, a clock, and a coffee station.
An EV charging station area with palm trees and a building in the background.

10. Best Western Americana Inn

Best Western Americana Inn
San Ysidro
CNY701
CNY797 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Americana Inn
A swimming pool with palm trees and a mountain in the background.
A modern lounge area with dark-toned seating, a central coffee table, and a stone accent wall.
A modern lounge area with leather seating, a central fire feature, and geometric patterned railings.
A modern bar area with a long counter, multiple stools, and a variety of bottles on shelves.

11. Sycuan Casino Resort

Sycuan Casino Resort
El Cajon
CNY660
CNY806 total
includes taxes & fees
Oct 15 - Oct 16
Sycuan Casino Resort
A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.
A compact hotel room with a kitchenette, a bed, a small seating area, and a window providing natural light.
A lobby with a curved carpet, two armchairs, a small table, and a large window with natural light.
A coastal view with a beach, ocean, and residential buildings.

12. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
Chula Vista
CNY1,178
CNY1,296 total
includes taxes & fees
Nov 5 - Nov 6
Holiday Inn Express San Diego South - Chula Vista by IHG
An outdoor patio area with seating and a bar.
A spacious lobby with modern seating, large windows, and a view of the street.
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.
A modern hotel with a prominent sign reading "AYRES HOTEL".

13. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
Otay Ranch
CNY1,289
CNY1,420 total
includes taxes & fees
Nov 11 - Nov 12
Ayres Hotel San Diego South - Chula Vista
A multi-story hotel with a prominent entrance, a stone facade, and a clear sky.
A reception area with a wooden reception desk, a grey carpet, and a glass door entrance.
A modern living room with a wooden dining table, grey sofas, and a flat-screen TV mounted on the wall.
A hotel room with two beds, a window with blinds, a heater, a bedside table with a lamp, and a wooden wardrobe.

14. WoodSpring Suites Santee - San Diego Northeast

WoodSpring Suites Santee - San Diego Northeast
Santee
CNY663
CNY729 total
includes taxes & fees
Oct 18 - Oct 19
WoodSpring Suites Santee - San Diego Northeast
A patio area with outdoor seating, a fire feature, and palm trees.
A swimming pool with a visible water filtration system and a tiled edge.
A multi-level hotel lobby with dining areas, a reception desk, and a large TV screen.
An outdoor patio with a stone fire pit, outdoor seating, string lights, and a tall, narrow heater.

15. Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla
University City
CNY1,132
CNY1,492 total
includes taxes & fees
Oct 31 - Nov 1
Embassy Suites by Hilton San Diego La Jolla
An outdoor seating area with wicker chairs and a fire pit, surrounded by palm trees and string lights.
A poolside area with a concrete pool, lounge chairs, and a wooden deck.
A spacious lobby with a central seating area, a staircase, and a view of the hallway leading to the entrance.
A grand lobby with a marble floor, a central table with floral arrangements, a staircase, and potted plants.

16. DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley
Mission Valley
CNY961
CNY1,105 total
includes taxes & fees
Nov 8 - Nov 9
DoubleTree by Hilton Hotel San Diego - Mission Valley
A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.
A hotel entrance with a covered walkway, palm trees, and a parking area.
A spacious lobby with a round table, blue benches, a large painting, and a view of the outdoors.
A spacious lobby with a high ceiling, a central seating area with sofas and armchairs, a coffee table, and a potted plant.

17. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
National City
CNY1,018
CNY1,122 total
includes taxes & fees
Oct 25 - Oct 26
Best Western Plus Marina Gateway Hotel
A modern building with multiple windows, outdoor seating, and a chessboard.
A spacious indoor area with a pool table, seating, and a staircase.
A Hampton Inn & Suites by Hilton building with a covered entrance and a prominent sign.
A modern hotel reception area with a marble counter, a 'Welcome to Hampton' sign, and a reception desk.

18. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
Point Loma
CNY1,132
CNY1,301 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
A hotel room with a large bed, a desk with a computer, a red chair, and a view of the city.
A hotel room with a desk, office chair, and a sofa with a throw pillow.
A conference room with a long table, chairs, a projector screen, and large windows with a view of outdoor umbrellas.
A gym with treadmills, elliptical machines, and weight benches.

19. Country Inn & Suites by Radisson, San Diego North, CA

Country Inn & Suites by Radisson, San Diego North, CA
Sorrento Valley
CNY1,018
CNY1,170 total
includes taxes & fees
Oct 18 - Oct 19
Country Inn & Suites by Radisson, San Diego North, CA
A hotel breakfast area with a long counter displaying various food items, including fruits, pastries, and a coffee station.
A hotel room with a large bed, a TV, a desk with a lamp, and a bookshelf.
A reception area with a modern design, featuring a reception desk, a check-in counter, and a wall-mounted sign indicating check-in and check-out times.
A swimming pool with lounge chairs, palm trees, and a building in the background.

20. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Mission Valley
CNY917
CNY1,055 total
includes taxes & fees
Oct 12 - Oct 13
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
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A hotel room with a bed, a bedside table with a phone, and a nightstand.
A motel with a red-tiled roof, multiple balconies, and a sign indicating room number 6.
A hotel room with a large window, a poster on the wall, and a tiled floor.
A building with a '6' sign, surrounded by lush greenery and palm trees.

Motel 6 La Mesa, CA - San Diego

Motel 6 La Mesa, CA - San Diego
La Mesa
CNY282 off
CNY763
per night
CNY1,680 total
includes taxes & fees
Motel 6 La Mesa, CA - San Diego
A spacious lobby with leather sofas, a round coffee table with fruit, and a ceiling adorned with colorful hanging ornaments.
A hotel room with a large bed, a sofa, a nightstand with a lamp, and a vase of flowers.
A breakfast bar with a variety of fruits, a Hershey's chocolate bar, and a coffee machine.
A swimming pool with a wooden deck, lounge chairs, and a gated entrance.

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
La Mesa
CNY2,001
per night
CNY4,402 total
includes taxes & fees
Sign in for extra savings
Best Western Plus La Mesa San Diego
A building with a 'Lobby' and 'Vacancy' sign, surrounded by a variety of flowering plants.
A swimming pool with a metal ladder, a blue chair, and a white chair.
A hotel room with two beds, a chair, a desk, and a lamp.
A vending machine with snacks and a Coca-Cola machine.

Heritage Inn La Mesa

Heritage Inn La Mesa
La Mesa
CNY180 off
CNY810
per night
CNY1,785 total
includes taxes & fees
Heritage Inn La Mesa
A spacious living room with two sofas, a coffee table, and a staircase leading to an upper level.
A swimming pool with a tiled edge, a patio area with chairs, and a house in the background.
A living room with leather sofas, a flat-screen TV, a fireplace, and a dining table.
A dining area with a glass table, wooden chairs, and a chandelier.

Spacious Getaway w/ Pool in La Mesa!

Spacious Getaway w/ Pool in La Mesa!
Casa de Oro-Mount Helix
We have 1 left at
CNY1,934
per night
CNY6,831 total
includes taxes & fees
Spacious Getaway w/ Pool in La Mesa!
A modern hotel room with two beds, a balcony, and a desk.
A motel with a red-tiled roof, multiple balconies, and a parking area with several vehicles.
A motel with a prominent '6' sign, a parking lot with several cars, and a well-lit entrance.
A modern reception area with a digital screen, a small table with chairs, and a coffee machine.

Motel 6 La Mesa, CA

Motel 6 La Mesa, CA
La Mesa
CNY970
per night
CNY2,135 total
includes taxes & fees
Sign in for extra savings
Motel 6 La Mesa, CA
Our prices for hotels in La Mesa are cheapest in February
Price trends for hotels in La Mesa
Pricing is based on two traveler single night rates
View properties in October
Typical weather for La Mesa
October
High 26°C / low 16°C. Sunny most days.
View properties in October
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Top neighborhoods in La Mesa

A town with a mountain in the background, a clear sky, and scattered clouds.
A town with a mountain in the background.

Casa de Oro-Mount Helix

La Mesa's Casa de Oro-Mount Helix neighborhood offers attractions including Mount Helix Park.

A large white cross against a cloudy sky.

Mount Helix

The Mount Helix neighborhood offers attractions such as Mount Helix Park and FAITH CHAPEL.

Top landmarks in La Mesa

Mount Helix Park

7.4/10 (59 reviews)
If you're planning a bit of sightseeing head to Mount Helix Park— just one of the monuments in Casa de Oro-Mount Helix. Why not take a stroll along the port and watch the sunset while you're here?
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FAITH CHAPEL

FAITH CHAPEL is a venue in Mount Helix.
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La Mesa Memorial Fine Arts Center

La Mesa Memorial Fine Arts Center is in the heart of La Mesa, so why not stop by during your stay. If you have fun at La Mesa Memorial Fine Arts Center, you'll love San Diego Zoo, which isn't far.
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The Bancroft

If you find yourself in Mount Helix, you can stop off for a few drinks or snacks at The Bancroft.
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Learn more about La Mesa

Between the bustle of San Diego and the quiet of the hills, La Mesa lives up to its 'Jewel of the Hills' nickname without trying too hard. The historic Village area offers boutiques and cafés where locals actually eat, not just places that survive on tourist traffic. Mount Helix rewards a short climb with panoramic views that explain why everyone in California seems suspiciously content. Lake Murray Park provides a refreshing escape where fishing lines dangle alongside kayakers who've discovered this urban oasis. Train enthusiasts find unexpected delight at the Pacific Southwest Railway Museum, where vintage locomotives sit frozen in time.

See all hotels in La Mesa
A sunset over a mountainous landscape with scattered clouds.

Check out reviews of La Mesa hotels guests love

Sheraton San Diego Resort

Sheraton San Diego Resort

10/10 Excellent
"Was a great stay and 5 minute Airport Shuttle which was awesome!!!"
Peggy 1-night trip
Posted 3 hours ago
Sheraton San Diego Resort
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

10/10 Excellent
"My stay was excellent everything was great nice place"
Sharhonda 4-night trip
Posted 8 hours ago
Days Inn by Wyndham San Diego Hotel Circle
Paradise Point Resort & Spa

Paradise Point Resort & Spa

8/10 Good
"Lot of walk can get lost"
Valerie 3-night trip
Posted 9 hours ago
Paradise Point Resort & Spa
Kings Inn San Diego

Kings Inn San Diego

8/10 Good
"The hotel is not new but well maintained. Situated within the facility is a great breakfast and lunch restaurant the Waffle Stop."
Stevan 1-night trip
Posted 10 hours ago
Kings Inn San Diego
Bay Club Hotel & Marina

Bay Club Hotel & Marina

8/10 Good
"Clean and safe"
Jorge 2-night trip
Posted 10 hours ago
Bay Club Hotel & Marina
Handlery Hotel

Handlery Hotel

10/10 Excellent
"Staff was helpful and welcoming. The room was clean and quiet. Would go back again!"
Christa 1-night trip
Posted 1 day ago
Handlery Hotel
The Dana on Mission Bay

The Dana on Mission Bay

10/10 Excellent
"Our 5 day stay at the Dana was awesome. The grounds are well kept and beautiful. The staff were all so friendly. The Firefly restaurant was delicious and so convenient. Being on a marina the views are amazing especially the stunning sunsets. You can rent bikes , kayaks and jet skis for a fee. The pools were refreshing. The rooms were very clean and they replenished the towels each day. Some say the rooms are outdated a bit but didn’t bother us. You’re on vacation, in the rooms to sleep. Our king size bed and the pillows were comfy . They have a free shuttle that took us to SeaWorld and back….that was cool. We loved our stay and had no complaints. We will be back again."
Stacey 5-night trip
Posted 1 day ago
The Dana on Mission Bay

Frequently asked questions

How much does a hotel room cost in La Mesa?
You can find top hotels in La Mesa from CNY561 with options to suit your budget and needs. If you're after an affordable hotel in La Mesa that meets all of your requirements, set your filters and then sort the results by "Price: low to high".
How can I find deals and earn rewards at La Mesa hotels?
Discover great deals on La Mesa hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on La Mesa hotels.
Can I book La Mesa hotels with free cancellation?
To book a refundable La Mesa hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What are some popular hotels in central La Mesa?
For hotels in central La Mesa, check out Courtyard by Marriott San Diego El Cajon and Holiday Inn Express La Mesa Near SDSU by IHG. Travelers love Courtyard by Marriott San Diego El Cajon for its location, as well as the outdoor pool, restaurant and bar/lounge this hotel offers. Holiday Inn Express La Mesa Near SDSU by IHG is another popular central hotel with an outdoor pool, a free buffet breakfast and a gym. When you stay at one of these central hotels, you'll be in easy reach of top sights including Snapdragon Stadium. North Park and Mid-City are some of the most central neighborhoods for your La Mesa vacation.
What accommodations do travelers like in La Mesa?
Guests like Best Western Seven Seas, Wyndham San Diego Bayside and Handlery Hotel.
Can I book a refundable accommodation in La Mesa?
If you need the flexibility to change your travel plans to La Mesa, most hotels offer refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in La Mesa if I want a vacation home instead of a hotel?
If you're looking for a good alternative to a hotel, review our selection of 65 vacation homes. In addition, you can choose from 10 apartments.
What will the weather in La Mesa be like during my trip?
August and September are typically the warmest months in La Mesa when the average temp is 72°F. February and January are the coldest months when the average temperature is 56°F. December and February are the months with the most rain.
Why should I book my La Mesa hotel through Hotels.com?
There are lots of reasons to book your La Mesa trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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