Hotels in South Main

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Tonight
Aug 31 - Sep 1
Tomorrow
Sep 1 - Sep 2
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Where to stay in South Main?

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.
A hotel room with a blue sofa, a desk with a lamp, a chair, a window with curtains, and two framed pictures on the wall.
A spacious lobby with a reception desk, two sofas, a coffee station, and large windows providing natural light.
A Comfort Suites hotel entrance with a covered walkway, a sign, and a parking area.

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
South Main
United States
LaKeisha
CNY662
CNY774 total
includes taxes & fees
Sep 8 - Sep 9
Comfort Suites Houston near Medical Center- NRG Stadium
A modern lobby with a blue carpet, seating area, and large windows.
A spacious hall with a patterned carpet, a red curtain backdrop, and a grand chandelier.
A lobby with a bar area, leather seating, and a stone wall.
A hotel room with two beds, a nightstand with lamps, a window with curtains, and a framed picture on the wall.

Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center
South Main
United States
Luis
CNY633
CNY740 total
includes taxes & fees
Sep 7 - Sep 8
Wyndham Houston at Reliant Park & Medical Center
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.
A self-service breakfast bar with a coffee machine, cereal dispensers, and a refrigerated display.
A vending machine and a Coca-Cola refrigerator in a hallway with tiled flooring and a ceiling with fluorescent lights.
A lobby with a black leather sofa, wooden coffee table, and two upholstered chairs. A reception desk is visible in the background.

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
South Main
United States
HERBERT
CNY468
CNY548 total
includes taxes & fees
Sep 14 - Sep 15
Quality Inn & Suites NRG Park - Medical Center
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.
A hotel with a central entrance, multiple floors, and a parking area with handicapped accessibility.
A living room with a sofa, armchairs, a coffee table, a TV, and a clock on the wall.
A hotel room with a bed, two bedside tables, lamps, a clock, and a phone.

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
South Main
United States
Barbara
CNY559
CNY653 total
includes taxes & fees
Sep 14 - Sep 15
Candlewood Suites Houston Medical Center by IHG
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.
A hotel room with a bed, a desk, a chair, a sofa, and a TV.
A swimming pool with lounge chairs and umbrellas, surrounded by a building with multiple windows and a gated entrance.
A modern lobby with seating areas, a reception desk, and a view of the outside.

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
1.4 km from South Main
United States
Martha
CNY794
CNY934 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.
A modern bar area with a long counter, multiple bar stools, and a variety of bottles and glasses.
A modern reception area with a wooden reception desk, a coffee machine, and a seating area with a sofa and armchairs.
A spacious indoor area with high ceilings, large windows, and modern furniture.

Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
Texas Medical Center, 3.1 km from South Main
United States
Marcus
CNY842
CNY990 total
includes taxes & fees
Sep 6 - Sep 7
Hyatt Place Houston Medical Center
A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.
A GoBoard® displaying the time, weather, and news.
A hotel pool area with a bar, seating, and a view of the building's exterior.
A Courtyard by Marriott hotel with a central courtyard, multiple floors, and a parking lot.

Courtyard By Marriott Houston Medical Center Reliant Park

Courtyard By Marriott Houston Medical Center Reliant Park
2.7 km from South Main
United States
Meredith
CNY709
CNY838 total
includes taxes & fees
Sep 18 - Sep 19
Courtyard By Marriott Houston Medical Center Reliant Park
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.
A modern bar area with a long counter, multiple bar stools, and a variety of bottles and glasses.
A modern hotel room with a grey sectional sofa, a flat-screen TV, a desk with a lamp, and a cityscape view.
A spacious indoor area with high ceilings, large windows, and modern furniture.

Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
Texas Medical Center, 3.1 km from South Main
United States
estella
CNY850
CNY1,000 total
includes taxes & fees
Sep 7 - Sep 8
Hyatt House Houston Medical Center
A rooftop pool area with lounge chairs and a view of a tall building at night.
A modern hotel lobby with wooden flooring, contemporary chairs, and illuminated ceiling panels.
A rooftop terrace with outdoor seating, a pool, and city views.
A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
Texas Medical Center, 4.4 km from South Main
United States
Sheila
CNY921
CNY1,147 total
includes taxes & fees
Sep 6 - Sep 7
The Westin Houston Medical Center/Museum District
A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.
A hotel room with a bed, a desk, a chair, a TV, and a wardrobe.
A modern interior with a seating area, a bar with a green wall, and a window with artwork.
A restaurant with wooden tables and chairs, a bar area, and a green wall with a TV.

Hotel Ylem

Hotel Ylem
2.3 km from South Main
United States
Monica
CNY525
CNY648 total
includes taxes & fees
Sep 9 - Sep 10
Hotel Ylem
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.
A dining table set with plates, cutlery, glasses, and candles, surrounded by chairs in a formal dining area.
A modern lobby with seating areas, a reception desk, and decorative wall art.
A modern bar area with a long counter, multiple seating options, and a variety of liquor bottles on shelves.

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
Texas Medical Center, 4.4 km from South Main
United States
Cathy
CNY551
CNY653 total
includes taxes & fees
Sep 7 - Sep 8
Hilton Houston Plaza/Medical Center
A spacious living area with a dining table, chairs, and a chandelier.
A high-rise hotel with a rooftop pool, multiple floors, and a city skyline in the background.
A restaurant with tables set for dining, surrounded by wicker chairs and potted plants.
A hotel room with a bed, a nightstand, a desk with a chair, a large mirror, and a chandelier.

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
6.3 km from South Main
United States
Justus
CNY1,394
CNY1,897 total
includes taxes & fees
Sep 2 - Sep 3
Hotel Zaza Houston Museum District
A modern hotel interior with a central spiral staircase, large glass windows, and a buffet area with various food items.
A hotel entrance with a modern design, a covered walkway, and a car parked outside.
A modern hotel with a curved entrance, a prominent logo, and a glass facade.
A multi-level hotel interior with a central spiral staircase, a glass elevator, and a patterned carpet.

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
The Galleria, 8.8 km from South Main
United States
Eduardo
CNY801
CNY937 total
includes taxes & fees
Sep 4 - Sep 5
The Royal Sonesta Houston Galleria
A hotel entrance with a covered walkway, a 'No Parking' sign, and a 'Home 2 Suites by Hilton' sign.
A modern outdoor seating area with colorful striped cushions and a round orange ottoman.
An indoor swimming pool with lounge chairs and yellow chairs around it.
A balcony with a view of a city skyline, a blue sofa, and a tiled floor.

Home2 Suites by Hilton at the Galleria

Home2 Suites by Hilton at the Galleria
Greater Uptown, 8 km from South Main
United States
Kevin
CNY712
CNY833 total
includes taxes & fees
Sep 7 - Sep 8
Home2 Suites by Hilton at the Galleria
A rooftop pool area with a covered seating area, a pool with a metal railing, and a cityscape view in the background.
A modern living room with a sectional sofa, a coffee table, and a TV area.
A Staybridge Suites hotel with a modern facade, large glass windows, and a prominent Holiday Inn Express sign.
A rooftop pool area with lounge chairs, a pergola, and a view of surrounding buildings.

Holiday Inn Express Houston - Galleria Area by IHG

Holiday Inn Express Houston - Galleria Area by IHG
The Galleria, 8.6 km from South Main
United States
Carl
CNY794
CNY929 total
includes taxes & fees
Sep 4 - Sep 5
Holiday Inn Express Houston - Galleria Area by IHG
A hotel room with a sofa, ottoman, desk, and a bed.
A multi-story hotel with a modern design, featuring a prominent 'Hyatt Place' sign on the facade and a well-lit entrance.
A modern hotel lobby with a wooden reception desk, comfortable seating, and a large decorative wall piece.
A modern indoor pool area with clear glass walls, lounge chairs, and a view of the cityscape.

Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
8.7 km from South Main
United States
desiree
CNY774
CNY910 total
includes taxes & fees
Sep 7 - Sep 8
Hyatt Place Houston/Galleria
A spacious lobby with a central dining area, seating arrangements, and a large flat-screen TV.
An indoor swimming pool with clear water, a tiled floor, and a pool ladder.
An outdoor patio area with a stone floor, orange cushioned seating, and a pergola structure.
A hotel dining area with a long communal table, multiple chairs, and a sofa.

Hampton Inn & Suites Houston Heights I-10

Hampton Inn & Suites Houston Heights I-10
Washington Ave./ Memorial Park, 11.8 km from South Main
United States
Dwight
CNY712
CNY833 total
includes taxes & fees
Sep 20 - Sep 21
Hampton Inn & Suites Houston Heights I-10
A hotel lobby with a hot tub, a pool, and a dining area.
A spacious lobby with a high ceiling, a mezzanine level, and a variety of seating options including sofas and armchairs.
A hotel lobby with a reception desk, seating area, and a television mounted on the wall.
A hotel room with a large bed, a desk with a TV, a chair, a lamp, and a cityscape painting on the wall.

Drury Inn & Suites Houston Near the Galleria

Drury Inn & Suites Houston Near the Galleria
The Galleria, 9.4 km from South Main
United States
Darla
CNY632
CNY740 total
includes taxes & fees
Sep 6 - Sep 7
Drury Inn & Suites Houston Near the Galleria
A modern high-rise building with a glass facade, multiple floors, and a rooftop parking area.
A rooftop pool with lounge chairs and a view of city buildings.
A modern living room with a large window, a flat-screen TV, a green sofa, a glass coffee table, and a dining area with a table and chairs.
A modern hotel lobby with a bar area, seating arrangements, and large windows providing natural light.

The Laura Hotel, Houston Downtown, Autograph Collection

The Laura Hotel, Houston Downtown, Autograph Collection
Houston Central Business District, 10.4 km from South Main
United States
Nia
CNY1,070
CNY1,463 total
includes taxes & fees
Sep 4 - Sep 5
The Laura Hotel, Houston Downtown, Autograph Collection
A modern living room with a glass table, a sofa, a TV, and a staircase with a city view.
A spacious lobby with a seating area, a large flat-screen TV, and a modern chandelier.
A spacious dining area with high ceilings, large windows, and a green seating area.
A modern urban landscape with high-rise buildings, a well-maintained road, and green spaces.

DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
Greenway Plaza-Upper Kirby, 6.6 km from South Main
United States
Nicole
CNY601
CNY704 total
includes taxes & fees
Sep 14 - Sep 15
DoubleTree by Hilton Hotel Houston - Greenway Plaza
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Our prices for hotels in South Main are cheapest in September
Price trends for hotels in South Main
Pricing is based on two traveler single night rates
View properties in September
Typical weather for Houston
September
High 32°C / low 23°C. Sunny most days.
View properties in September
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Monthly weather averages (˚C)

Check out reviews of South Main hotels guests love

Cambria Hotel Houston Downtown Convention Center

Cambria Hotel Houston Downtown Convention Center

8/10 Good
"Would recommend to anyone"
Taheim 5-night trip
Posted less than an hour ago
Cambria Hotel Houston Downtown Convention Center
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

10/10 Excellent
"Great for a weekend getaway"
Denise 1-night trip
Posted 2 hours ago
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

8/10 Good
"Buen servicio, faltó mantenimiento en las instalaciones"
Daniela 1-night trip
Posted 3 hours ago
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

10/10 Excellent
"Great hotel. Definitely would recommend to anyone."
Kendall 2-night trip
Posted 6 hours ago
Hilton Houston Plaza/Medical Center
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

10/10 Excellent
"The room was clean and the staff was great. First time staying here for my birthday weekend and also wedding…"
Elizabeth 1-night trip
Posted 10 hours ago
Club Quarters Hotel Downtown, Houston
Hyatt Place Houston Downtown

Hyatt Place Houston Downtown

10/10 Excellent
"K"
michael 2-night trip
Posted 11 hours ago
Hyatt Place Houston Downtown
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

10/10 Excellent
"Lovely place."
Eduard 1-night trip
Posted 11 hours ago
Hotel Zaza Houston Museum District
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

10/10 Excellent
"Good hotel"
bongjae 4-night trip
Posted 18 hours ago
Hyatt Regency Houston/Galleria
The Moran CITYCENTRE

The Moran CITYCENTRE

10/10 Excellent
"Our room was very clean. We’ve stayed at this hotel many times in the past and have always enjoyed it. The staff at check in wasn’t as friendly as usual and I had to ask for my bottle of wine that was included in our room."
Melissa 1-night trip
Posted 1 day ago
The Moran CITYCENTRE

Frequently asked questions

Is South Main expensive to stay in?
You can find great hotels from CNY472 in South Main to suit a range of budgets. To find the best low-cost hotel on Hotels.com that meets your needs, apply your search filters and then sort hotels by "Price: low to high".
How can I find discounted rates and deals for South Main hotels?
Discover great deals on hotels in South Main with Hotels.com. Sign up for free to unlock member only prices and start earning rewards. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on South Main hotels.
Can I receive a refund if I cancel my South Main hotel booking?
The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel your booking. Some South Main hotels require you to cancel more than 24 hours before check-in, so look at your booking beforehand. For extra peace of mind before you book, filter hotels by "Property cancellation options" and select "Fully refundable property".
What are some of the best pet-friendly hotels in South Main?
Traveling with your pet doesn't mean sacrificing a great hotel stay. In South Main, our travelers love:
What are some of the best South Main hotels for couples?
One of the best South Main hotels for couples is Wingate Houston near NRG Park/Medical Center. Wingate Houston near NRG Park/Medical Center is a popular hotel with an outdoor pool. Find more romantic South Main hotels by using the "Traveler experience" filter in your search and selecting "Adults only" or "Romantic".
What are some of the best South Main hotels with a pool?
Book a South Main hotel with a pool for some added relaxation or exercise on your trip. Wyndham Houston near NRG Park/Medical Center is a top-rated hotel with an outdoor pool, and an average guest score of 7.2 out of 10. This hotel also features a restaurant and a bar/lounge. Wingate Houston near NRG Park/Medical Center is another great hotel that features an outdoor pool, along with a free continental breakfast and a gym. For more South Main hotels with a pool, use the "Amenities" filter in your search and select "Pool" on Hotels.com.
Is it worth staying in South Main?
You're spoilt for choice with 60 hotels in the area so it's easy to find your perfect somewhere. Basing yourself in South Main makes it easy to explore Houston, including the neighborhoods of The Galleria and Texas Medical Center.
Which station is best for South Main?
The main station in South Main is Fannin South Station. If you're staying at a hotel in South Main, check out the nearest station so that you can get around and explore with ease.
What are some great hotels in South Main with balconies?
There are some top hotels in South Main that offer rooms with a balcony. Check out Wyndham Houston near NRG Park/Medical Center which has a high guest score of 7.2 out of 10, and balconies in some rooms.
Find out more about South Main

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