Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Santee on Hotels.com. These Santee hotels consistently deliver on comfort, location and traveler experience. Last updated on .
Hotels in Santee
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Where to stay in Santee?

Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott SanteeSantee
9.8 out of 10, Exceptional, (1,004 reviews)
The price is CNY908
CNY1,007 total
includes taxes & fees
Jul 1 - Jul 2

Hampton Inn Santee-I-95
Hampton Inn Santee-I-95Santee
9.6 out of 10, Exceptional, (1,003 reviews)
The price is CNY845
CNY938 total
includes taxes & fees
Jul 6 - Jul 7

Tru By Hilton Santee
Tru By Hilton SanteeSantee
9.2 out of 10, Wonderful, (863 reviews)
The price is CNY717
CNY796 total
includes taxes & fees
Jul 8 - Jul 9

Best Western Plus Santee Inn
Best Western Plus Santee InnSantee
8.8 out of 10, Excellent, (1,005 reviews)
The price is CNY758
CNY841 total
includes taxes & fees
Jun 25 - Jun 26

Comfort Inn & Suites Santee
Comfort Inn & Suites SanteeSantee
8.0 out of 10, Very Good, (1,004 reviews)
The price is CNY711
CNY789 total
includes taxes & fees
Jul 20 - Jul 21

Baymont by Wyndham Santee
Baymont by Wyndham SanteeSantee
8.0 out of 10, Very Good, (1,474 reviews)
The price is CNY508
CNY563 total
includes taxes & fees
Jun 25 - Jun 26

Holiday Inn Santee by IHG
Holiday Inn Santee by IHGSantee
8.2 out of 10, Very Good, (1,000 reviews)
The price is CNY671
CNY745 total
includes taxes & fees
Jun 28 - Jun 29

Travelodge by Wyndham Santee
Travelodge by Wyndham SanteeSantee
7.2 out of 10, Good, (742 reviews)
The price is CNY426
CNY473 total
includes taxes & fees
Jun 25 - Jun 26

Super 8 by Wyndham Santee/I-95
Super 8 by Wyndham Santee/I-95Santee
6.8 out of 10, (468 reviews)
The price is CNY431
CNY479 total
includes taxes & fees
Jun 29 - Jun 30

Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95Santee
6.4 out of 10, (566 reviews)
The price is CNY488
CNY542 total
includes taxes & fees
Jul 20 - Jul 21

Red Roof Inn Santee
Red Roof Inn SanteeSantee
6.6 out of 10, (656 reviews)
The price is CNY426
CNY473 total
includes taxes & fees
Jun 30 - Jul 1

Quality Inn & Suites Santee I-95
Quality Inn & Suites Santee I-95Santee
6.0 out of 10, (547 reviews)
The price is CNY375
CNY454 total
includes taxes & fees
Jul 14 - Jul 15

Econo Lodge Santee
Econo Lodge SanteeSantee
6.4 out of 10, (314 reviews)
The price is CNY409
CNY454 total
includes taxes & fees
Jul 19 - Jul 20

Doyles B and B at Players course LLC
Doyles B and B at Players course LLCManning
The price is CNY1,227
CNY1,362 total
includes taxes & fees
Jul 15 - Jul 16

Peach Tree Inn
Peach Tree InnSt. George
7.2 out of 10, Good, (230 reviews)
The price is CNY417
CNY450 total
includes taxes & fees
Jun 24 - Jun 25

Hampton Inn & Suites Orangeburg
Hampton Inn & Suites OrangeburgOrangeburg
9.4 out of 10, Exceptional, (811 reviews)
The price is CNY882
CNY980 total
includes taxes & fees
Jul 12 - Jul 13

Fairfield Inn by Marriott Orangeburg
Fairfield Inn by Marriott OrangeburgOrangeburg
8.4 out of 10, Very Good, (787 reviews)
The price is CNY786
CNY872 total
includes taxes & fees
Jun 24 - Jun 25

SpringHill Suites by Marriott Orangeburg
SpringHill Suites by Marriott OrangeburgOrangeburg
8.8 out of 10, Excellent, (771 reviews)
The price is CNY709
CNY787 total
includes taxes & fees
Jul 6 - Jul 7

Tru by Hilton Orangeburg
Tru by Hilton OrangeburgOrangeburg
9.2 out of 10, Wonderful, (1,004 reviews)
The price is CNY771
CNY856 total
includes taxes & fees
Jul 6 - Jul 7

Holiday Inn Express & Suites Orangeburg by IHG
Holiday Inn Express & Suites Orangeburg by IHGOrangeburg
8.6 out of 10, Excellent, (837 reviews)
The price is CNY860
CNY954 total
includes taxes & fees
Jul 5 - Jul 6
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Showing deals for:Jun 23 - Jun 24

8.8 out of 10, Excellent, (1,005 reviews)
We have 1 left at
The price is CNY743
per night
CNY824 total
includes taxes & fees
Showing deals for:Jun 24 - Jun 25

8.8 out of 10, Excellent, (1,005 reviews)
The price is CNY759
per night
CNY842 total
includes taxes & fees
Showing deals for:Jul 3 - Jul 5

8.8 out of 10, Excellent, (1,005 reviews)
The price is CNY905
per night
CNY2,010 total
includes taxes & fees
Check out pet-friendly hotels in Santee

9.8 out of 10, Exceptional, (1004)
The price is CNY908
CNY1,007 total
includes taxes & fees
Jul 1 - Jul 2
You may also like hotels with pools in Santee

9.8 out of 10, Exceptional, (1004)
The price is CNY908
CNY1,007 total
includes taxes & fees
Jul 1 - Jul 2
You can also stay at family-friendly hotels in Santee

9.8 out of 10, Exceptional, (1004)
The price is CNY908
CNY1,007 total
includes taxes & fees
Jul 1 - Jul 2
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Santee
Family friendly
Pet friendly
Top landmarks in Santee
Learn more about Santee
Tee off at championship golf courses or cast a line in Lake Marion's fish-rich waters where locals claim the bass practically jump into your boat. The Santee National Wildlife Refuge offers hiking trails where alligators sun themselves with reptilian nonchalance. Interstate 95 crosses the lake on a causeway that provides views worth pulling over for (safely, of course). Santee State Park delivers lakeside tranquility that makes visitors forget their phones exist. This resort town punches well above its weight with dining options that range from fresh-caught catfish to surprisingly sophisticated fare. The recent addition of the Santee Cooper Regional Water System has locals buzzing about growth while still cherishing their small-town atmosphere.

Check out reviews of Santee hotels guests love

Hampton Inn Santee-I-95
10/10 Excellent
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